Mechanical loading on cell-free polymer composite scaffold enhances in situ regeneration of fully functional Achilles tendon in a rabbit model
Wang W, Lin X, Tu T, Guo Z, Song Z, Jiang Y, Zhou B, Lei D, Wang X, Zhang W, Zhou G, Yi B, Zhang P, Liu W. Mechanical loading on cell-free polymer composite scaffold enhances in situ regeneration of fully functional Achilles tendon in a rabbit model. Biomaterials Advances 2024, 163: 213950. PMID: 38972278, DOI: 10.1016/j.bioadv.2024.213950.Peer-Reviewed Original ResearchMechanical loadingComposite scaffoldsMechanical propertiesIn situ tendon regenerationTendon regenerationPorous composite scaffoldsCell-loaded scaffoldsEnhanced mechanical propertiesInduce tenogenic differentiationAchilles tendon regenerationHybrid yarnsPGA fibersScaffold productionTendon engineeringHost cell infiltrationTransmission electron microscopePolylactic acidFilament fibersMelt spinningNative tendonLoadElectron microscopeMatrix modificationApplication potentialPolyglycolic acid