2017
Diverse p53/DNA binding modes expand the repertoire of p53 response elements
Vyas P, Beno I, Xi Z, Stein Y, Golovenko D, Kessler N, Rotter V, Shakked Z, Haran T. Diverse p53/DNA binding modes expand the repertoire of p53 response elements. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 10624-10629. PMID: 28912355, PMCID: PMC5635862, DOI: 10.1073/pnas.1618005114.Peer-Reviewed Original ResearchConceptsP53 response elementNatural response elementsResponse elementTetrameric complexCanonical p53 response elementBulk genomic DNAAdjacent spacer sequencesCanonical binding siteP53 binding siteExpression of genesBinding sitesCellular outcomesTranscription factorsDNA sitesP53 bindsSpacer sequencesP53 actsP53 dimersSpecific complexDimer bindsGenomic DNABase pairsPhysiological relevanceFunctional significanceSecond binds
2010
Anomalous DNA binding by E2 regulatory protein driven by spacer sequence TATA
Xi Z, Zhang Y, Hegde RS, Shakked Z, Crothers DM. Anomalous DNA binding by E2 regulatory protein driven by spacer sequence TATA. Nucleic Acids Research 2010, 38: 3827-3833. PMID: 20185566, PMCID: PMC2887970, DOI: 10.1093/nar/gkq114.Peer-Reviewed Original Research
2004
Predicting indirect readout effects in protein–DNA interactions
Zhang Y, Xi Z, Hegde RS, Shakked Z, Crothers DM. Predicting indirect readout effects in protein–DNA interactions. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 8337-8341. PMID: 15148366, PMCID: PMC420395, DOI: 10.1073/pnas.0402319101.Peer-Reviewed Original Research