Diverse p53/DNA binding modes expand the repertoire of p53 response elements
Vyas P, Beno I, Xi Z, Stein Y, Golovenko D, Kessler N, Rotter V, Shakked Z, Haran T. Diverse p53/DNA binding modes expand the repertoire of p53 response elements. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 10624-10629. PMID: 28912355, PMCID: PMC5635862, DOI: 10.1073/pnas.1618005114.Peer-Reviewed Original ResearchConceptsP53 response elementNatural response elementsResponse elementTetrameric complexCanonical p53 response elementBulk genomic DNAAdjacent spacer sequencesCanonical binding siteP53 binding siteExpression of genesBinding sitesCellular outcomesTranscription factorsDNA sitesP53 bindsSpacer sequencesP53 actsP53 dimersSpecific complexDimer bindsGenomic DNABase pairsPhysiological relevanceFunctional significanceSecond binds