2012
Inhibition of farnesyltransferase reduces angiogenesis by interrupting endothelial cell migration
Peng G, Ren Y, Sun X, Zhou J, Li D. Inhibition of farnesyltransferase reduces angiogenesis by interrupting endothelial cell migration. Biochemical Pharmacology 2012, 83: 1374-1382. PMID: 22382068, DOI: 10.1016/j.bcp.2012.02.008.Peer-Reviewed Original ResearchConceptsEndothelial cellsCell migrationInhibition of farnesyltransferaseTherapeutic targetTumor cellsCancer treatmentEndothelial cell migrationUse of FTIsProtein 1Cancer therapyAngiogenesisPseudopodia formationInhibition of FTaseInhibitors of farnesyltransferaseInhibitionCellsLocalization of EB1Novel insightsPhysiological processesTherapy
2011
Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner
Li D, Xie S, Ren Y, Huo L, Gao J, Cui D, Liu M, Zhou J. Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner. Protein & Cell 2011, 2: 150-160. PMID: 21359602, PMCID: PMC4875255, DOI: 10.1007/s13238-011-1015-4.Peer-Reviewed Original ResearchConceptsHistone deacetylase 6Molecular mechanismsCell migrationEB1-dependent mannerEndothelial cell migrationCell motilityNovel playerCapillary-like structuresEndothelial cellsEndothelial tube formationNew capillary vesselsCell polarizationHDAC6 activityMicrotubule endsNew blood vesselsNovel insightsProtein 1Vascular endothelial cellsTube formationBlood vasculatureCapillary sproutingAngiogenic processChick embryosAngiogenesisImportant process