2024
De Novo Elastin Assembly Alleviates Development of Supravalvular Aortic Stenosis—Brief Report
Ellis M, Riaz M, Huang Y, Anderson C, Hoareau M, Li X, Luo H, Lee S, Park J, Luo J, Batty L, Huang Q, Lopez C, Reinhardt D, Tellides G, Qyang Y. De Novo Elastin Assembly Alleviates Development of Supravalvular Aortic Stenosis—Brief Report. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 1674-1682. PMID: 38752350, PMCID: PMC11209776, DOI: 10.1161/atvbaha.124.320790.Peer-Reviewed Original ResearchSupravalvular aortic stenosisVascular smooth muscle cellsSmooth muscle cellsMuscle cellsAortic stenosisMedial vascular smooth muscle cellsVascular proliferative diseasesEpigallocatechin gallate treatmentProliferative abnormalitiesPreclinical findingsHeart failureLuminal occlusionMouse modelCell hyperproliferationDefective elastinProliferative diseasesCardiovascular disordersFormation of elastinTherapeutic interventionsElastin assemblyElastin depositionStenosisMiceAortic mechanicsImproper formation
2022
Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy
Riaz M, Park J, Sewanan LR, Ren Y, Schwan J, Das SK, Pomianowski PT, Huang Y, Ellis MW, Luo J, Liu J, Song L, Chen IP, Qiu C, Yazawa M, Tellides G, Hwa J, Young LH, Yang L, Marboe CC, Jacoby DL, Campbell SG, Qyang Y. Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy. Circulation 2022, 145: 1238-1253. PMID: 35384713, PMCID: PMC9109819, DOI: 10.1161/circulationaha.121.056265.Peer-Reviewed Original ResearchConceptsHypertrophic cardiomyopathySarcomeric mutationsFamilial hypertrophic cardiomyopathySudden cardiac deathCardiac myosin heavy chainMechanism-based treatmentsDevelopment of hypertrophyActivated T cellsCalcineurin-nuclear factorForce productionPhenotypic expressionPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesHeart failureCardiac deathVentricular hypertrophyCell-derived cardiomyocytesCardiac contractilityPharmacological interventionsT cellsCardiac diseaseCardiac hypertrophyPatient-specific induced pluripotent stem cellsPharmacological meansTwitch relaxation
2019
Modular design of a tissue engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes
Park J, Anderson CW, Sewanan LR, Kural MH, Huang Y, Luo J, Gui L, Riaz M, Lopez CA, Ng R, Das SK, Wang J, Niklason L, Campbell SG, Qyang Y. Modular design of a tissue engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes. Acta Biomaterialia 2019, 102: 220-230. PMID: 31634626, PMCID: PMC7227659, DOI: 10.1016/j.actbio.2019.10.019.Peer-Reviewed Original ResearchConceptsSingle-ventricle cardiac defectsHuman umbilical arteryPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesFontan procedureSurgical interventionSVD patientsCell-derived cardiomyocytesFontan conduitTherapeutic potentialEngineered Heart TissueVascular conduitsCongenital disorderDesign strategyVariety of complicationsEfficient electrical conductivitySingle ventricle heartPrimary cardiac fibroblastsFontan circulationHeart failureCorrective surgeryUmbilical arteryPulmonary circulationBiodegradable materialsPulmonary system
2014
Functional Cardiomyocytes Derived from Isl1 Cardiac Progenitors via Bmp4 Stimulation
Cagavi E, Bartulos O, Suh CY, Sun B, Yue Z, Jiang Z, Yue L, Qyang Y. Functional Cardiomyocytes Derived from Isl1 Cardiac Progenitors via Bmp4 Stimulation. PLOS ONE 2014, 9: e110752. PMID: 25522363, PMCID: PMC4270687, DOI: 10.1371/journal.pone.0110752.Peer-Reviewed Original ResearchConceptsCardiac progenitor cellsCardiac repairProliferative abilityProgenitor cellsCell-based cardiac regenerative therapySignificant therapeutic valueCardiac regenerative therapyAdult cardiac progenitor cellsStem cellsCPC culturesHigh proliferative abilityHeart failureCardiac originCardiac differentiationMyocardial infarctionAnterior heart fieldInduction of Bmp4Leading causePotential treatmentRole of BMP4Therapeutic valueCardiac progenitorsUntreated cardiomyocytesProtein expressionRegenerative therapy