2023
Comparison of the prognostic value between quantification and visual estimation of coronary calcification from attenuation CT in patients undergoing SPECT myocardial perfusion imaging
Feher A, Pieszko K, Shanbhag A, Lemley M, Miller R, Huang C, Miras L, Liu Y, Gerber J, Sinusas A, Miller E, Slomka P. Comparison of the prognostic value between quantification and visual estimation of coronary calcification from attenuation CT in patients undergoing SPECT myocardial perfusion imaging. The International Journal Of Cardiovascular Imaging 2023, 40: 185-193. PMID: 37845406, PMCID: PMC466934, DOI: 10.1007/s10554-023-02980-1.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsCoronary artery calcificationMyocardial perfusion imagingCT myocardial perfusion imagingSPECT/CT myocardial perfusion imagingArtery calcificationPrognostic valuePrior coronary stentingAdverse cardiovascular eventsSimilar prognostic valueSPECT myocardial perfusionREFINE SPECT registrySPECT/CTCardiovascular eventsCAC scoringCalcium scoreCoronary calcificationCoronary stentingPrognostic utilitySingle centerCoronary arteryLow doseMyocardial perfusionPerfusion imagingSurvival analysis
2022
Integration of coronary artery calcium scoring from CT attenuation scans by machine learning improves prediction of adverse cardiovascular events in patients undergoing SPECT/CT myocardial perfusion imaging
Feher A, Pieszko K, Miller R, Lemley M, Shanbhag A, Huang C, Miras L, Liu YH, Sinusas AJ, Miller EJ, Slomka PJ. Integration of coronary artery calcium scoring from CT attenuation scans by machine learning improves prediction of adverse cardiovascular events in patients undergoing SPECT/CT myocardial perfusion imaging. Journal Of Nuclear Cardiology 2022, 30: 590-603. PMID: 36195826, DOI: 10.1007/s12350-022-03099-x.Peer-Reviewed Original ResearchMeSH KeywordsAgedCalciumCoronary Artery DiseaseFemaleHumansMachine LearningMaleMiddle AgedMyocardial Perfusion ImagingPrognosisTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsMajor adverse cardiovascular eventsMyocardial perfusion imagingAdverse cardiovascular eventsSPECT myocardial perfusion imagingCAC scoringCardiovascular eventsPrediction of MACECoronary artery calcification (CAC) scoringMACE-free survivalClinical risk factorsCoronary artery calciumCT myocardial perfusion imagingReceiver operator characteristic curveSPECT/CT myocardial perfusion imagingSPECT/CTOperator characteristic curveCT myocardial perfusionArtery calciumCAC scoreAnalysis patientsMACE predictionSingle centerHigher event ratesRisk factorsRisk score
2021
Post-reconstruction attenuation correction for SPECT myocardium perfusion imaging facilitated by deep learning-based attenuation map generation
Liu H, Wu J, Shi L, Liu Y, Miller E, Sinusas A, Liu YH, Liu C. Post-reconstruction attenuation correction for SPECT myocardium perfusion imaging facilitated by deep learning-based attenuation map generation. Journal Of Nuclear Cardiology 2021, 29: 2881-2892. PMID: 34671940, DOI: 10.1007/s12350-021-02817-1.Peer-Reviewed Original ResearchDiagnostic accuracy of stress-only myocardial perfusion SPECT improved by deep learning
Liu H, Wu J, Miller EJ, Liu C, Yaqiang, Liu, Liu YH. Diagnostic accuracy of stress-only myocardial perfusion SPECT improved by deep learning. European Journal Of Nuclear Medicine And Molecular Imaging 2021, 48: 2793-2800. PMID: 33511425, DOI: 10.1007/s00259-021-05202-9.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Artery DiseaseDeep LearningFemaleHumansMaleMyocardial Perfusion ImagingPerfusionRetrospective StudiesSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonConceptsMyocardial perfusion imagingCoronary artery diseaseMyocardial perfusion abnormalitiesPerfusion abnormalitiesDiagnostic accuracyConvolutional neural networkTomography myocardial perfusion imagingYale-New Haven HospitalMyocardial perfusion defect sizeSPECT myocardial perfusion imagingAbnormal myocardial perfusionReceiver-operating characteristic curvePerfusion defect sizeNew Haven HospitalAUC valuesSingle photon emissionMyocardial perfusion SPECTDeep learningHigh diagnostic accuracyArtery diseaseDL methodsFinal diagnosisPatient genderMyocardial perfusionPerfusion SPECT
2020
Quantification of myocardial blood flow (MBF) and reserve (MFR) incorporated with a novel segmentation approach: Assessments of quantitative precision and the lower limit of normal MBF and MFR in patients
Liu H, Thorn S, Wu J, Fazzone-Chettiar R, Sandoval V, Miller EJ, Sinusas AJ, Liu YH. Quantification of myocardial blood flow (MBF) and reserve (MFR) incorporated with a novel segmentation approach: Assessments of quantitative precision and the lower limit of normal MBF and MFR in patients. Journal Of Nuclear Cardiology 2020, 28: 1236-1248. PMID: 32715416, DOI: 10.1007/s12350-020-02278-y.Peer-Reviewed Original Research
2016
High-Sensitivity and High-Resolution SPECT/CT Systems Provide Substantial Dose Reduction Without Compromising Quantitative Precision for Assessment of Myocardial Perfusion and Function
Palyo RJ, Sinusas A, Liu YH. High-Sensitivity and High-Resolution SPECT/CT Systems Provide Substantial Dose Reduction Without Compromising Quantitative Precision for Assessment of Myocardial Perfusion and Function. Journal Of Nuclear Medicine 2016, 57: 893-899. PMID: 26848173, DOI: 10.2967/jnumed.115.164632.Peer-Reviewed Original ResearchConceptsMyocardial perfusion SPECTEjection fractionDose reductionMyocardial perfusionAnterior descendingRight coronary artery territoryTetrofosmin myocardial perfusion SPECTNormal MPS resultsNuclear Cardiology guidelinesCoronary artery territoryLarge perfusion defectsLV ejection fractionLeft anterior descendingData of patientsNormal myocardial perfusionEnd-systolic volumeRelative dose reductionDefect sizeMPS resultsShort imaging protocolsTetrofosmin scanArtery territoryCardiology guidelinesSubstantial dose reductionLV function
2011
Accuracy and Reproducibility of Absolute Quantification of Myocardial Focal Tracer Uptake from Molecularly Targeted SPECT/CT: A Canine Validation
Liu YH, Sahul Z, Weyman CA, Dione DP, Dobrucki WL, Mekkaoui C, Brennan MP, Ryder WJ, Sinusas AJ. Accuracy and Reproducibility of Absolute Quantification of Myocardial Focal Tracer Uptake from Molecularly Targeted SPECT/CT: A Canine Validation. Journal Of Nuclear Medicine 2011, 52: 453-460. PMID: 21321271, PMCID: PMC3137905, DOI: 10.2967/jnumed.110.082214.Peer-Reviewed Original ResearchAnimalsDogsFemaleHeartImage Interpretation, Computer-AssistedMaleMetabolic Clearance RateMolecular ImagingMyocardial Perfusion ImagingMyocardiumRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueTissue DistributionTomography, Emission-Computed, Single-PhotonTomography, X-Ray Computed