2024
Pathogenic variants in autism gene KATNAL2 cause hydrocephalus and disrupt neuronal connectivity by impairing ciliary microtubule dynamics
DeSpenza T, Singh A, Allington G, Zhao S, Lee J, Kiziltug E, Prina M, Desmet N, Dang H, Fields J, Nelson-Williams C, Zhang J, Mekbib K, Dennis E, Mehta N, Duy P, Shimelis H, Walsh L, Marlier A, Deniz E, Lake E, Constable R, Hoffman E, Lifton R, Gulledge A, Fiering S, Moreno-De-Luca A, Haider S, Alper S, Jin S, Kahle K, Luikart B. Pathogenic variants in autism gene KATNAL2 cause hydrocephalus and disrupt neuronal connectivity by impairing ciliary microtubule dynamics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2314702121. PMID: 38916997, PMCID: PMC11228466, DOI: 10.1073/pnas.2314702121.Peer-Reviewed Original ResearchConceptsCongenital hydrocephalusCerebral ventriculomegalyPathogenic variantsPrefrontal pyramidal neuronsGenetic subsets of patientsDevelopment of ventriculomegalyRadial gliaSubsets of patientsHigh-frequency firingNeuronal connectivityHeterozygous germline variantsAutism spectrum disorderVentricular-subventricular zoneMicrotubule dynamicsImpaired spermatogenesisCSF shuntingExcitatory driveMicrotubule-severing ATPasePyramidal neuronsDisrupt neuronal connectivityGermline variantsVentriculomegalyCSF homeostasisDisrupt microtubule dynamicsPlanar cell polarityMultimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization
Vafaii H, Mandino F, Desrosiers-Grégoire G, O’Connor D, Markicevic M, Shen X, Ge X, Herman P, Hyder F, Papademetris X, Chakravarty M, Crair M, Constable R, Lake E, Pessoa L. Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization. Nature Communications 2024, 15: 229. PMID: 38172111, PMCID: PMC10764905, DOI: 10.1038/s41467-023-44363-z.Peer-Reviewed Original Research
2022
Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography
Mishra S, Herman P, Crair M, Constable R, Walsh J, Akif A, Verhagen J, Hyder F. Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography. Nanoscale 2022, 14: 17770-17788. PMID: 36437785, PMCID: PMC9850399, DOI: 10.1039/d2nr04878g.Peer-Reviewed Original ResearchConceptsProtein nanoparticlesParamagnetic iron oxide nanoparticlesIron oxide nanoparticlesMagnetic resonance imaging (MRI) contrastRelaxivity ratioOxide nanoparticlesRapid renal clearanceNanoparticlesMRI propertiesImaging contrastMRI contrastCitric acidNeuroscience applicationsFluorescent dyeBlood biochemical assaysUnambiguous detectionRelaxivityCerebral angiographyDyePlatformMajor blood vesselsBiochemical assaysTechnologyBrain capillariesFluorescence angiographyFunctional network properties derived from wide-field calcium imaging differ with wakefulness and across cell type
O’Connor D, Mandino F, Shen X, Horien C, Ge X, Herman P, Hyder F, Crair M, Papademetris X, Lake E, Constable. Functional network properties derived from wide-field calcium imaging differ with wakefulness and across cell type. NeuroImage 2022, 264: 119735. PMID: 36347441, PMCID: PMC9808917, DOI: 10.1016/j.neuroimage.2022.119735.Peer-Reviewed Original Research
2017
Topographic organization of the cerebral cortex and brain cartography
Eickhoff SB, Constable RT, Yeo BT. Topographic organization of the cerebral cortex and brain cartography. NeuroImage 2017, 170: 332-347. PMID: 28219775, PMCID: PMC5563483, DOI: 10.1016/j.neuroimage.2017.02.018.Peer-Reviewed Original Research
2001
Quantification of 3-D regional myocardial deformation: shape-based analysis of magnetic resonance images
Sinusas A, Papademetris X, Constable R, Dione D, Slade M, Shi P, Duncan J. Quantification of 3-D regional myocardial deformation: shape-based analysis of magnetic resonance images. AJP Heart And Circulatory Physiology 2001, 281: h698-h714. PMID: 11454574, DOI: 10.1152/ajpheart.2001.281.2.h698.Peer-Reviewed Original Research
1998
Physical and geometrical modeling for image-based recovery of left ventricular deformation
Duncan J, Shi P, Constable T, Sinusas A. Physical and geometrical modeling for image-based recovery of left ventricular deformation. Progress In Biophysics And Molecular Biology 1998, 69: 333-351. PMID: 9785945, DOI: 10.1016/s0079-6107(98)00014-5.Peer-Reviewed Original Research
1994
Development and evaluation of tracking algorithms for cardiac wall motion analysis using phase velocity MR imaging
Constable R, Rath K, Sinusas A, Gore J. Development and evaluation of tracking algorithms for cardiac wall motion analysis using phase velocity MR imaging. Magnetic Resonance In Medicine 1994, 32: 33-42. PMID: 8084235, DOI: 10.1002/mrm.1910320106.Peer-Reviewed Original ResearchBOLD MRI monitoring of changes in cerebral perfusion induced by acetazolamide and hypercarbia in the rat
Graham G, Zhong J, Petroff O, Constable R, Prichard J, Gore J. BOLD MRI monitoring of changes in cerebral perfusion induced by acetazolamide and hypercarbia in the rat. Magnetic Resonance In Medicine 1994, 31: 557-560. PMID: 8015411, DOI: 10.1002/mrm.1910310514.Peer-Reviewed Original ResearchConceptsApparent diffusion coefficientNormal human subjectsMRI changesCerebral perfusionCerebrovascular reserveCerebrovascular diseaseAnatomic mappingRatsMRI monitoringSignificant decreaseHuman subjectsMRI methodsMRI signalHypercarbiaPatientsInhalationPerfusionReactivity patternsAcetazolamideDiseaseAdministration