2022
232-OR: Alterations in Decision-Making Neurocircuits during Hypoglycemia in Patients with T1DM
DEAJON-JACKSON J, RANGEL E, LACADIE C, GREENE A, BELFORT-DEAGUIAR R, CONSTABLE T, ROTHMAN D, HWANG J. 232-OR: Alterations in Decision-Making Neurocircuits during Hypoglycemia in Patients with T1DM. Diabetes 2022, 71 DOI: 10.2337/db22-232-or.Peer-Reviewed Original ResearchDorsal anterior cingulate cortexGroup x Session interactionFunctional connectivityOrbitofrontal cortexControl subjectsNon-diabetic control subjectsHealthy control subjectsState functional connectivityDirect neuronal connectionsRegional brain activityAnterior cingulate cortexSeed-based analysisBOLD-fMRI scanningHyperinsulinemic euglycemicHypoglycemic clampT1DM patientsSession interactionT1DM subjectsGlucose levelsT1DMHypoglycemiaNeurocognitive changesNeuronal connectionsCingulate cortexCognitive function
2018
Hypoglycemia Unawareness in T1DM Is Associated with Altered Brain Default Mode Network Connectivity
GROSKREUTZ D, HWANG J, SEO D, LACADIE C, PARIKH L, BELFORT-DEAGUIAR R, SCHEINOST D, SINHA R, CONSTABLE T, SHERWIN R. Hypoglycemia Unawareness in T1DM Is Associated with Altered Brain Default Mode Network Connectivity. Diabetes 2018, 67 DOI: 10.2337/db18-11-lb.Peer-Reviewed Original ResearchDefault mode networkHypoglycemia awarenessDMN connectivityAvoidance of hypoglycemiaDefault mode network connectivityHypoglycemia symptom scoresMode network connectivityBrain connectivity patternsBOLD-fMRI scanningMannKind CorporationT1DM individualsHypoglycemia unawarenessHypoglycemic clampSymptom scoresRegeneron PharmaceuticalsGlaxoSmithKline plcPlasma cortisolState connectivityMode networkFMRI scanningHypoglycemiaElicit changesBrainFunctional networksConnectivity patterns