2021
Longitudinal hippocampal circuit change differentiates persistence and remission of pediatric posttraumatic stress disorder
George G, Keding T, Heyn S, Herringa R. Longitudinal hippocampal circuit change differentiates persistence and remission of pediatric posttraumatic stress disorder. Depression And Anxiety 2021, 39: 8-18. PMID: 34843625, PMCID: PMC8763137, DOI: 10.1002/da.23229.Peer-Reviewed Original ResearchConceptsPediatric posttraumatic stress disorderFunctional magnetic resonance imagingPosttraumatic stress disorderTD youthHippocampal activationStress disorderFunctional connectivityEmotional processing taskFunctional brain substratesHippocampal functional connectivityFunctional connectivity analysisFunctional brain abnormalitiesPTSD youthEmotion processingThreat stimuliNeutral imagesPediatric PTSDBrain substratesPTSD groupActivation findingsConnectivity analysisProcessing tasksVisual cortexLongitudinal studyYouth
2018
Abnormal Prefrontal Development in Pediatric Posttraumatic Stress Disorder: A Longitudinal Structural and Functional Magnetic Resonance Imaging Study
Heyn SA, Keding TJ, Ross MC, Cisler JM, Mumford JA, Herringa RJ. Abnormal Prefrontal Development in Pediatric Posttraumatic Stress Disorder: A Longitudinal Structural and Functional Magnetic Resonance Imaging Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 4: 171-179. PMID: 30343133, PMCID: PMC6371792, DOI: 10.1016/j.bpsc.2018.07.013.Peer-Reviewed Original ResearchConceptsPediatric posttraumatic stress disorderPediatric PTSDGray matter volumeVentrolateral prefrontal cortexVentromedial prefrontal cortexPosttraumatic stress disorderPrefrontal cortexStress disorderFunctional magnetic resonance imaging studyBilateral ventrolateral prefrontal cortexRight ventromedial prefrontal cortexFunctional magnetic resonance imagingSelf-referential processingIntrinsic connectivity analysesDorsolateral prefrontal cortexResting-state functional magnetic resonance imagingPrefrontal gray matter volumeWhole-brain structural analysisFunctional brain abnormalitiesMagnetic resonance imaging studyResonance imaging studyGray matter developmentPrefrontal developmentNormative decreaseStructural magnetic resonance
2016
Default-Mode Network Abnormalities in Pediatric Posttraumatic Stress Disorder
Patriat R, Birn RM, Keding TJ, Herringa RJ. Default-Mode Network Abnormalities in Pediatric Posttraumatic Stress Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: 319-327. PMID: 27015723, PMCID: PMC4808564, DOI: 10.1016/j.jaac.2016.01.010.Peer-Reviewed Original ResearchConceptsPediatric posttraumatic stress disorderPosttraumatic stress disorderTask-positive networkAttentional control networkRe-experiencing symptomsDefault mode network abnormalitiesGreater anticorrelationStress disorderDMN connectivityAdult posttraumatic stress disorderFunctional magnetic resonance imaging studyLarge-scale network abnormalitiesTrauma-related thoughtsNetwork abnormalitiesControl networkResting-state functional magnetic resonance imaging studyPrefrontal cortex connectivityIndependent component analysisSeed-based connectivityMagnetic resonance imaging studyAutobiographical memoryResonance imaging studyCortex connectivityHealthy youthNeurodevelopmental factors