Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis
Cheng S, Xia I, Wanner R, Abello J, Stratman A, Nicoli S. Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis. ELife 2024, 13: rp94094. PMID: 38985140, PMCID: PMC11236418, DOI: 10.7554/elife.94094.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsWall shear stressVascular smooth muscle cell differentiationVSMC differentiationEndothelial cellsAnalysis of blood flowBlood flowShear stressBrain arteriesPulsatile flowCerebrovascular diseaseDedifferentiated vascular smooth muscle cellsRegulate cerebral blood flowSmooth muscle cellsRed blood cell velocityDedifferentiation of vascular smooth muscle cellsCerebral blood flowBlood cell velocityArterial muscularizationVenous plexusCell progenitorsMuscle cellsBlood flow activationArteryFlow