A Conserved Allosteric Pathway in Tyrosine Kinase Regulation
Marsiglia WM, Katigbak J, Zheng S, Mohammadi M, Zhang Y, Traaseth NJ. A Conserved Allosteric Pathway in Tyrosine Kinase Regulation. Structure 2019, 27: 1308-1315.e3. PMID: 31204250, PMCID: PMC6687525, DOI: 10.1016/j.str.2019.05.002.Peer-Reviewed Original ResearchConceptsTyrosine kinaseTyrosine kinase regulationAllosteric control mechanismReceptor tyrosine kinasesTyrosine kinase familyKinase regulationDFG motifActivation loopAllosteric pathwayKinase familyMutational disruptionKinase hingeInactive conformationHydrophobic residuesHuman diseasesKinaseConformational perturbationsCombination of NMREnzyme thermostabilityMutationsSkeletal syndromeActive siteMolecular dynamics simulationsThermostabilityStructural analysis