2012
Network Meta-analysis of Margin Threshold for Women With Ductal Carcinoma In Situ
Wang SY, Chu H, Shamliyan T, Jalal H, Kuntz KM, Kane RL, Virnig BA. Network Meta-analysis of Margin Threshold for Women With Ductal Carcinoma In Situ. Journal Of The National Cancer Institute 2012, 104: 507-516. PMID: 22440677, PMCID: PMC3916966, DOI: 10.1093/jnci/djs142.Peer-Reviewed Original ResearchConceptsIpsilateral breast tumor recurrenceBreast-conserving surgeryRisk of IBTRNegative marginsPositive marginsDuctal carcinomaOdds ratioBreast tumor recurrenceNegative surgical marginsNetwork Meta-AnalysisMixed treatment comparisonMargin thresholdIBTR eventsDCIS patientsMargin statusSurgical marginsTumor recurrenceMeta-regression techniquesReduced riskLower riskPatientsPubMed databaseCosmetic constraintsMeta-AnalysisRadiotherapy
2011
Tumor characteristics as predictors of local recurrence after treatment of ductal carcinoma in situ: a meta-analysis
Wang SY, Shamliyan T, Virnig BA, Kane R. Tumor characteristics as predictors of local recurrence after treatment of ductal carcinoma in situ: a meta-analysis. Breast Cancer Research And Treatment 2011, 127: 1-14. PMID: 21327465, DOI: 10.1007/s10549-011-1387-4.Peer-Reviewed Original ResearchConceptsIpsilateral breast tumor recurrenceHER2/neu receptorTumor characteristicsLocal recurrenceDuctal carcinomaTumor sizeTumor gradeLow-risk DCIS patientsNeu receptorManagement of DCISBreast tumor recurrenceHigh-quality evidenceCourse of treatmentDCIS patientsAggressive treatmentPrognostic factorsSurgical marginsTumor recurrenceSubgroup analysisObservational studyMethod of detectionEligible articlesSystematic reviewRecurrenceDCIS
2010
Association Between Patient and Tumor Characteristics With Clinical Outcomes in Women With Ductal Carcinoma In Situ
Shamliyan T, Wang SY, Virnig BA, Tuttle TM, Kane RL. Association Between Patient and Tumor Characteristics With Clinical Outcomes in Women With Ductal Carcinoma In Situ. JNCI Monographs 2010, 2010: 121-129. PMID: 20956815, PMCID: PMC5161074, DOI: 10.1093/jncimonographs/lgq034.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedBody Mass IndexBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingFemaleGonadal Steroid HormonesHumansMammographyMenopauseNeoplasm Recurrence, LocalNeoplasms, Hormone-DependentPrognosisRacial GroupsRandomized Controlled Trials as TopicReceptor, ErbB-2Receptors, EstrogenReceptors, ProgesteroneRiskSocioeconomic FactorsTreatment OutcomeTumor BurdenConceptsDuctal carcinomaClinical outcomesRecurrent cancerTumor characteristicsWorse outcomesNegative estrogen receptor statusAdvanced recurrent cancerPositive surgical marginsEstrogen receptor statusLarger tumor sizeHigh-risk categoryComposite prognostic indicesReceptor statusSurgical marginsPrognostic indexTumor sizeComedo necrosisPathological gradingClinical trialsObservational studyHigh riskHER2 receptorSynthesis of evidenceHigh mortalityYoung women