2020
Reprogramming progressive cells display low CAG promoter activity
Hu X, Wu Q, Zhang J, Kim J, Chen X, Hartman AA, Eastman AE, Park I, Guo S. Reprogramming progressive cells display low CAG promoter activity. Stem Cells 2020, 39: 43-54. PMID: 33075202, PMCID: PMC7821215, DOI: 10.1002/stem.3295.Peer-Reviewed Original Research
2015
Choosing Cell Fate Through a Dynamic Cell Cycle
Chen X, Hartman A, Guo S. Choosing Cell Fate Through a Dynamic Cell Cycle. Current Stem Cell Reports 2015, 1: 129-138. PMID: 28725536, PMCID: PMC5487535, DOI: 10.1007/s40778-015-0018-0.Peer-Reviewed Original ResearchCell fate changesCell fateCell cycle dynamicsFate changesSomatic cellsDifferentiated somatic cell typesCell cycleCell fate specificationCell fate determinationInduction of pluripotencyTranscription factor concentrationsSomatic cell typesFate specificationFate determinationCell cycle accelerationCycle dynamicsTissue homeostasisDevelopmental systemsYamanaka factorsCell typesNormal developmentPluripotencyRecent discoveryReprogrammingFate
2014
Nonstochastic Reprogramming from a Privileged Somatic Cell State
Guo S, Zi X, Schulz VP, Cheng J, Zhong M, Koochaki SH, Megyola CM, Pan X, Heydari K, Weissman SM, Gallagher PG, Krause DS, Fan R, Lu J. Nonstochastic Reprogramming from a Privileged Somatic Cell State. Cell 2014, 156: 649-662. PMID: 24486105, PMCID: PMC4318260, DOI: 10.1016/j.cell.2014.01.020.Peer-Reviewed Original ResearchConceptsSomatic cell stateCell statesAcquisition of pluripotencyMurine hematopoietic progenitorsEndogenous Oct4Cell cycle accelerationNonstochastic mannerSomatic cellsProgeny cellsPluripotent fateYamanaka factorsCell cycleHematopoietic progenitorsP53 knockdownPluripotencyReprogrammingCycling populationFactor expressionCellsFibroblastsImportant bottleneckKnockdownProgenitorsFateExpression