2019
Sex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction
Nanna MG, Hajduk AM, Krumholz HM, Murphy TE, Dreyer RP, Alexander KP, Geda M, Tsang S, Welty FK, Safdar B, Lakshminarayan DK, Chaudhry SI, Dodson JA. Sex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005691. PMID: 31607145, PMCID: PMC6913190, DOI: 10.1161/circoutcomes.119.005691.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overComorbidityDisability EvaluationFemaleHealth Status DisparitiesHealthcare DisparitiesHumansLife StyleMaleMyocardial RevascularizationNon-ST Elevated Myocardial InfarctionPatient AdmissionPrevalenceProspective StudiesRisk AssessmentRisk FactorsSex FactorsSocial Determinants of HealthST Elevation Myocardial InfarctionTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionSex-based differencesPercutaneous coronary interventionFunctional impairmentOlder adultsHospital complicationsCoronary interventionOlder patientsCoronary diseaseMyocardial infarctionAge-related functional impairmentsAge-associated functional impairmentsLower ratesPrior coronary diseaseObstructive coronary diseaseProspective observational studyNSTEMI subgroupSTEMI subgroupUnderwent revascularizationAcute myocardialChest painClinical presentationAMI subgroupRisk factorsHigh prevalence
2016
Restricting Symptoms Before and After Admission to Hospice
Cheraghlou S, Gahbauer EA, Leo-Summers L, Stabenau HF, Chaudhry SI, Gill TM. Restricting Symptoms Before and After Admission to Hospice. The American Journal Of Medicine 2016, 129: 754.e7-754.e15. PMID: 26968471, PMCID: PMC4914433, DOI: 10.1016/j.amjmed.2016.02.017.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overChest PainCognitive DysfunctionCohort StudiesDepressionDiarrheaDizzinessDyspneaEdemaFatigueFemaleHospice CareHospicesHumansIndependent LivingLongitudinal StudiesMaleMemory DisordersMuscle WeaknessMusculoskeletal PainNauseaPatient AdmissionPrevalenceProspective StudiesSleep Wake DisordersUnited StatesUrologic DiseasesVision DisordersVomitingConceptsHospice admissionEnd of lifeDistressing symptomsMean numberCommunity-dwelling older personsMonthly telephone interviewsOngoing cohort studyMonths of lifeEffect of hospiceHospice treatmentAdmission diagnosisEarly referralMedian durationCohort studySymptom prevalenceSuch symptomsSymptom increasesAdmissionPsychological symptomsSymptomsOlder personsRestricted activityHospiceTelephone interviewsPrevalence
2015
Burden of Comorbidities and Functional and Cognitive Impairments in Elderly Patients at the Initial Diagnosis of Heart Failure and Their Impact on Total Mortality The Cardiovascular Health Study
Murad K, Goff DC, Morgan TM, Burke GL, Bartz TM, Kizer JR, Chaudhry SI, Gottdiener JS, Kitzman DW. Burden of Comorbidities and Functional and Cognitive Impairments in Elderly Patients at the Initial Diagnosis of Heart Failure and Their Impact on Total Mortality The Cardiovascular Health Study. JACC Heart Failure 2015, 3: 542-550. PMID: 26160370, PMCID: PMC4499113, DOI: 10.1016/j.jchf.2015.03.004.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overAtrial FibrillationCognition DisordersCohort StudiesComorbidityCoronary DiseaseFemaleHeart FailureHumansHypertensionIncidenceLongitudinal StudiesMalePeripheral Arterial DiseasePhysical FitnessPrevalenceProportional Hazards ModelsPulmonary Disease, Chronic ObstructiveConceptsIncident heart failureCardiovascular Health StudyHeart failureGreater mortality riskMortality riskPercent of participantsCognitive impairmentElderly patientsFunctional impairmentDaily livingHealth StudyBurden of comorbiditiesChronic kidney diseaseMultivariable-adjusted modelsTotal mortality riskRelevant comorbiditiesDiabetes mellitusInitial diagnosisCerebrovascular diseaseKidney diseaseMean ageHigh burdenComorbiditiesInstrumental activitiesMortality rate
2013
Cognitive Impairment in Older Adults with Heart Failure: Prevalence, Documentation, and Impact on Outcomes
Dodson JA, Truong TT, Towle VR, Kerins G, Chaudhry SI. Cognitive Impairment in Older Adults with Heart Failure: Prevalence, Documentation, and Impact on Outcomes. The American Journal Of Medicine 2013, 126: 120-126. PMID: 23331439, PMCID: PMC3553506, DOI: 10.1016/j.amjmed.2012.05.029.Peer-Reviewed Original ResearchConceptsHeart failureCognitive impairmentOlder adultsPhysician documentationSevere impairmentCox proportional hazards regressionFolstein Mini-Mental State ExaminationMini-Mental State ExaminationProportion of patientsProspective cohort studyTime of hospitalizationProportional hazards regressionTime of dischargeHospital discharge summariesYears of ageMild cognitive impairmentMultivariable adjustmentCohort studyHospital dischargeHospital readmissionHazards regressionMean agePrimary diagnosisState ExaminationPatients
2011
Impact of Comorbidity on Mortality Among Older Persons with Advanced Heart Failure
Ahluwalia SC, Gross CP, Chaudhry SI, Ning YM, Leo-Summers L, Van Ness PH, Fried TR. Impact of Comorbidity on Mortality Among Older Persons with Advanced Heart Failure. Journal Of General Internal Medicine 2011, 27: 513-519. PMID: 22095572, PMCID: PMC3326095, DOI: 10.1007/s11606-011-1930-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overChronic DiseaseCohort StudiesComorbidityFemaleHeart DiseasesHeart FailureHip FracturesHospitalizationHumansKaplan-Meier EstimateKidney DiseasesLongitudinal StudiesMaleMedicarePrevalencePrognosisPulmonary Disease, Chronic ObstructiveRetrospective StudiesRisk FactorsUnited StatesConceptsChronic obstructive pulmonary diseaseImpact of comorbiditiesAdvanced heart failureHeart failureHigher mortality riskMortality riskComorbidity burdenHip fractureMyocardial infarctionOlder adultsCount of conditionsOverall comorbidity burdenRetrospective cohort studyContribution of comorbiditiesObstructive pulmonary diseaseProportional hazards regressionLower mortality riskLife-prolonging interventionsHF mortalityHospitalized beneficiariesMost comorbiditiesCohort studyIndividual comorbiditiesPrior hospitalizationPulmonary diseaseChange in Comorbidity Prevalence with Advancing Age Among Persons with Heart Failure
Ahluwalia SC, Gross CP, Chaudhry SI, Leo-Summers L, Van Ness PH, Fried TR. Change in Comorbidity Prevalence with Advancing Age Among Persons with Heart Failure. Journal Of General Internal Medicine 2011, 26: 1145-1151. PMID: 21573881, PMCID: PMC3181289, DOI: 10.1007/s11606-011-1725-6.Peer-Reviewed Original ResearchConceptsHeart failureDiscordant comorbiditiesComorbidity burdenMedicare beneficiariesDiscordant conditionsOlder personsChronic Conditions WarehouseCount of conditionsOverall comorbidity burdenHigher overall burdenOlder Medicare beneficiariesPatterns of comorbidityComorbidity prevalencePrimary illnessPrevalence increasesOverall burdenMedian numberComorbiditiesGreater prevalenceAge strataConcordant conditionsPrevalenceUnrelated conditionsOverall managementOlder beneficiaries