2022
A risk model for decline in health status after acute myocardial infarction among older adults
Hajduk A, Dodson J, Murphy T, Chaudhry S. A risk model for decline in health status after acute myocardial infarction among older adults. Journal Of The American Geriatrics Society 2022, 71: 1228-1235. PMID: 36519774, PMCID: PMC10089939, DOI: 10.1111/jgs.18162.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth status declineImportant patient-centered outcomesPatient-centered outcomesMyocardial infarctionStatus declineHealth statusOlder adultsShort Form-12 Physical Component ScorePhysical component scoreProspective cohort studyRisk prediction modelLogistic regression modelsOlder adult survivorsPredictive risk modelRisk modelCohort studyPatient ageValidation cohortC-statisticRisk factorsHigh riskLower riskAdult survivorsHospitalization
2020
Risk Model for Decline in Activities of Daily Living Among Older Adults Hospitalized With Acute Myocardial Infarction: The SILVER‐AMI Study
Hajduk AM, Dodson JA, Murphy TE, Tsang S, Geda M, Ouellet GM, Gill TM, Brush JE, Chaudhry SI. Risk Model for Decline in Activities of Daily Living Among Older Adults Hospitalized With Acute Myocardial Infarction: The SILVER‐AMI Study. Journal Of The American Heart Association 2020, 9: e015555. PMID: 33000681, PMCID: PMC7792390, DOI: 10.1161/jaha.119.015555.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionDaily living declineSILVER-AMI StudyDaily livingOlder patientsMonths postdischargeMyocardial infarctionFunctional declineImportant patient-centered outcomesPoor long-term outcomesLonger hospital stayLong-term outcomesPatient-centered outcomesGeriatric impairmentsHospital stayAMI survivorsClinical variablesMean ageMedical recordsRisk factorsRestorative therapyPhysical activityAMI hospitalizationPsychosocial factorsUS hospitalsPresentation, Treatment, and Outcomes of the Oldest-Old Patients with Acute Myocardial Infarction: The SILVER-AMI Study
Gupta A, Tsang S, Hajduk A, Krumholz HM, Nanna MG, Green P, Dodson JA, Chaudhry SI. Presentation, Treatment, and Outcomes of the Oldest-Old Patients with Acute Myocardial Infarction: The SILVER-AMI Study. The American Journal Of Medicine 2020, 134: 95-103. PMID: 32805225, PMCID: PMC7752813, DOI: 10.1016/j.amjmed.2020.07.020.Peer-Reviewed Original ResearchConceptsOldest-old patientsMyocardial infarctionFunctional impairmentOlder patientsMobility impairmentsCox proportional hazards regressionMiddle-old patientsProportional hazards regressionAcute myocardial infarctionCase fatality rateAcute myocardial infarction hospitalizationsSILVER-AMI StudyYears of ageMyocardial infarction hospitalizationsChest painCoronary revascularizationAtypical presentationHazards regressionClinical variablesRisk factorsAdvanced agePrimary symptomsPatientsFatality rateHealth status
2019
Sex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction
Nanna MG, Hajduk AM, Krumholz HM, Murphy TE, Dreyer RP, Alexander KP, Geda M, Tsang S, Welty FK, Safdar B, Lakshminarayan DK, Chaudhry SI, Dodson JA. Sex-Based Differences in Presentation, Treatment, and Complications Among Older Adults Hospitalized for Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005691. PMID: 31607145, PMCID: PMC6913190, DOI: 10.1161/circoutcomes.119.005691.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overComorbidityDisability EvaluationFemaleHealth Status DisparitiesHealthcare DisparitiesHumansLife StyleMaleMyocardial RevascularizationNon-ST Elevated Myocardial InfarctionPatient AdmissionPrevalenceProspective StudiesRisk AssessmentRisk FactorsSex FactorsSocial Determinants of HealthST Elevation Myocardial InfarctionTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionSex-based differencesPercutaneous coronary interventionFunctional impairmentOlder adultsHospital complicationsCoronary interventionOlder patientsCoronary diseaseMyocardial infarctionAge-related functional impairmentsAge-associated functional impairmentsLower ratesPrior coronary diseaseObstructive coronary diseaseProspective observational studyNSTEMI subgroupSTEMI subgroupUnderwent revascularizationAcute myocardialChest painClinical presentationAMI subgroupRisk factorsHigh prevalenceAcute Kidney Injury Among Older Patients Undergoing Coronary Angiography for Acute Myocardial Infarction: The SILVER-AMI Study
Dodson JA, Hajduk A, Curtis J, Geda M, Krumholz HM, Song X, Tsang S, Blaum C, Miller P, Parikh CR, Chaudhry SI. Acute Kidney Injury Among Older Patients Undergoing Coronary Angiography for Acute Myocardial Infarction: The SILVER-AMI Study. The American Journal Of Medicine 2019, 132: e817-e826. PMID: 31170374, PMCID: PMC6891160, DOI: 10.1016/j.amjmed.2019.05.022.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAcute Kidney InjuryAge FactorsAgedAged, 80 and overCohort StudiesCoronary AngiographyDatabases, FactualFemaleGeriatric AssessmentHospital MortalityHospitalizationHumansKaplan-Meier EstimateLogistic ModelsMaleMyocardial InfarctionOdds RatioPrognosisProportional Hazards ModelsRisk AssessmentSeverity of Illness IndexSurvival AnalysisConceptsAcute kidney injuryAcute myocardial infarctionAge-related conditionsKidney injuryBody mass indexCoronary angiographyRisk factorsMyocardial infarctionOlder patientsMean ageAcute kidney injury risk factorsAcute Myocardial Infarction StudyAcute myocardial infarction cohortOlder adultsGlobal Outcomes criteriaMyocardial Infarction StudyInjury risk factorsParticipants' mean ageSILVER-AMI StudyMultivariable adjustmentComorbid diseasesHeart failureIndependent predictorsGeriatric conditionsMass index
2017
Prehospital Delay in Older Adults with Acute Myocardial Infarction: The ComprehenSIVe Evaluation of Risk Factors in Older Patients with Acute Myocardial Infarction Study
Ouellet GM, Geda M, Murphy TE, Tsang S, Tinetti ME, Chaudhry SI. Prehospital Delay in Older Adults with Acute Myocardial Infarction: The ComprehenSIVe Evaluation of Risk Factors in Older Patients with Acute Myocardial Infarction Study. Journal Of The American Geriatrics Society 2017, 65: 2391-2396. PMID: 29044463, PMCID: PMC5681402, DOI: 10.1111/jgs.15102.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAcute Myocardial Infarction StudyMyocardial Infarction StudyPrehospital delayOlder adultsOlder patientsHeart failureMyocardial infarctionRisk factorsFuture public health effortsContemporary national cohortMedical record abstractionPublic health effortsCross-sectional analysisAntiischemic therapyHospital presentationIndex hospitalizationHospital delaySymptom durationDiabetes mellitusClinical presentationComorbid conditionsRecord abstractionAtypical symptomsNonwhite raceCare Transitions Between Hospitals and Skilled Nursing Facilities: Perspectives of Sending and Receiving Providers
Britton MC, Ouellet GM, Minges KE, Gawel M, Hodshon B, Chaudhry SI. Care Transitions Between Hospitals and Skilled Nursing Facilities: Perspectives of Sending and Receiving Providers. The Joint Commission Journal On Quality And Patient Safety 2017, 43: 565-572. PMID: 29056176, PMCID: PMC5693352, DOI: 10.1016/j.jcjq.2017.06.004.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAttitude of Health PersonnelCommunicationHospital AdministrationHumansInsurance, Health, ReimbursementInterviews as TopicPatient DischargePatient ReadmissionPatient TransferQualitative ResearchQuality ImprovementRisk FactorsSeverity of Illness IndexSkilled Nursing FacilitiesUnited StatesConceptsSkilled nursing facilitiesCare transitionsNursing facilitiesSNF providersPatient-level risk factorsOptimal care settingAcute medical illnessUnplanned hospital readmissionComprehensive care planCost of careHospital readmissionMedical illnessComplex patientsRisk factorsMedicare patientsCare settingsCare plansPatient complexityHealth care institutionsPatient transferPsychosocial issuesHospitalPatientsSeparate hospitalsCare institutions
2016
Sedentary Behavior and Cardiovascular Risk in Older Adults: a Scoping Review
Hajduk AM, Chaudhry SI. Sedentary Behavior and Cardiovascular Risk in Older Adults: a Scoping Review. Current Cardiovascular Risk Reports 2016, 10: 5. PMID: 27375828, PMCID: PMC4927044, DOI: 10.1007/s12170-016-0485-6.BooksCardiovascular diseaseSedentary behaviorOlder adultsCardiovascular riskSedentary timeCardiac risk scoreHigh sedentary behaviorCardiac lipid profilesCardiovascular outcomesCVD incidenceBlood pressureCardiovascular healthRisk factorsLipid profileRisk scoreLarger sample sizeAdultsScoping ReviewAssociationRiskSample sizeReviewMortalityPrevalenceDisease
2015
Do Non-Clinical Factors Improve Prediction of Readmission Risk? Results From the Tele-HF Study
Krumholz HM, Chaudhry SI, Spertus JA, Mattera JA, Hodshon B, Herrin J. Do Non-Clinical Factors Improve Prediction of Readmission Risk? Results From the Tele-HF Study. JACC Heart Failure 2015, 4: 12-20. PMID: 26656140, PMCID: PMC5459404, DOI: 10.1016/j.jchf.2015.07.017.Peer-Reviewed Original ResearchConceptsReadmission ratesPatient-reported informationHeart failureHealth statusReadmission riskC-statisticRisk scorePsychosocial variablesMedical record abstractionWeeks of dischargeReadmission risk modelNon-clinical factorsCandidate risk factorsReadmission risk predictionRecord abstractionClinical variablesPatient interviewsMedical recordsRisk factorsPatientsPsychosocial informationPsychosocial characteristicsTelephone interviewsRisk predictionScoresPhysicians' perceptions of the Thrombolysis in Myocardial Infarction (TIMI) risk score in older adults with acute myocardial infarction
Feder SL, Schulman-Green D, Geda M, Williams K, Dodson JA, Nanna MG, Allore HG, Murphy TE, Tinetti ME, Gill TM, Chaudhry SI. Physicians' perceptions of the Thrombolysis in Myocardial Infarction (TIMI) risk score in older adults with acute myocardial infarction. Heart & Lung 2015, 44: 376-381. PMID: 26164651, PMCID: PMC4567390, DOI: 10.1016/j.hrtlng.2015.05.005.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial Infarction (TIMI) risk scoreRisk scoreOlder adultsMyocardial infarctionMedian sample ageTIMI risk scoreRisk stratification modelSemi-structured telephone interviewsRisk factorsNew risk modelAMI treatmentPhysicians' perceptionsMortality riskClinical experienceClinical practiceStratification modelTelephone interviewsAdultsThrombolysisInfarctionConstant comparative methodPhysiciansScoresQualitative study
2014
Design and rationale of the comprehensive evaluation of risk factors in older patients with AMI (SILVER-AMI) study
Dodson JA, Geda M, Krumholz HM, Lorenze N, Murphy TE, Allore HG, Charpentier P, Tsang SW, Acampora D, Tinetti ME, Gill TM, Chaudhry SI. Design and rationale of the comprehensive evaluation of risk factors in older patients with AMI (SILVER-AMI) study. BMC Health Services Research 2014, 14: 506. PMID: 25370536, PMCID: PMC4239317, DOI: 10.1186/s12913-014-0506-4.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth status declineOlder patientsRisk factorsGeriatric impairmentsHospital readmissionOlder adultsDetailed medical record abstractionStatus declineDiagnostic study resultsPost-AMI outcomesProportion of patientsProspective cohort studyMedical record abstractionAMI studyHealth status measuresClinical characteristicsCohort studyRecord abstractionAdverse outcomesMyocardial infarctionAcademic hospitalHospital assessmentMultivariable regressionStatus measures
2013
Risk Factors for Hospital Admission Among Older Persons With Newly Diagnosed Heart Failure Findings From the Cardiovascular Health Study
Chaudhry SI, McAvay G, Chen S, Whitson H, Newman AB, Krumholz HM, Gill TM. Risk Factors for Hospital Admission Among Older Persons With Newly Diagnosed Heart Failure Findings From the Cardiovascular Health Study. Journal Of The American College Of Cardiology 2013, 61: 635-642. PMID: 23391194, PMCID: PMC3576871, DOI: 10.1016/j.jacc.2012.11.027.Peer-Reviewed Original ResearchConceptsHeart failure diagnosisIndependent risk factorHospital admissionCardiovascular Health StudyHeart failureGeriatric conditionsRisk factorsMuscle weaknessSlow gaitOlder personsHealth StudyNew diagnosisNew York Heart Association functional class IIICommunity-living older personsDepressed ejection fractionHeart Failure FindingsFunctional class IIIChronic kidney diseaseCause hospital admissionsMedical record reviewRelevant clinical dataLong-term riskDiabetes mellitusEjection fractionKidney disease
2011
Risk Factors for Onset of Disability Among Older Persons Newly Diagnosed With Heart Failure: The Cardiovascular Health Study
Chaudhry SI, McAvay G, Ning Y, Allore HG, Newman AB, Gill TM. Risk Factors for Onset of Disability Among Older Persons Newly Diagnosed With Heart Failure: The Cardiovascular Health Study. Journal Of Cardiac Failure 2011, 17: 764-770. PMID: 21872147, PMCID: PMC3164529, DOI: 10.1016/j.cardfail.2011.04.015.Peer-Reviewed Original ResearchConceptsOnset of disabilityCardiovascular Health StudyHeart failureRisk factorsOlder personsHealth StudyHeart failure populationHeart failure diagnosisTime-dependent predictorsFailure populationGait speedStudy populationDepressive symptomsAnnual examinationsGreater riskDisabilityLongitudinal studyRegression modelingOnsetFirst yearFailureCommon occurrencePopulationPersonsParticipantsPatterns and Predictors of Recovery from Exhaustion in Older Adults: The Cardiovascular Health Study
Whitson HE, Thielke S, Diehr P, O'Hare AM, Chaves PH, Zakai NA, Arnold A, Chaudhry S, Ives D, Newman AB. Patterns and Predictors of Recovery from Exhaustion in Older Adults: The Cardiovascular Health Study. Journal Of The American Geriatrics Society 2011, 59: 207-213. PMID: 21288229, PMCID: PMC3059104, DOI: 10.1111/j.1532-5415.2010.03238.x.Peer-Reviewed Original ResearchConceptsHistory of cancerSelf-rated healthMore medicationsPoor self-rated healthOlder adultsCongestive heart failureHistory of strokeWorse self-rated healthCardiovascular Health StudyPredictors of recoveryProportional hazards modelPersistent exhaustionCohort studyHeart failureMusculoskeletal painHeart diseaseRisk factorsHealth StudyHazards modelAnnual examinationsOverall healthSecondary analysisOlder ageMedicationsTime points
2010
Geriatric Conditions and Subsequent Mortality in Older Patients With Heart Failure
Chaudhry SI, Wang Y, Gill TM, Krumholz HM. Geriatric Conditions and Subsequent Mortality in Older Patients With Heart Failure. Journal Of The American College Of Cardiology 2010, 55: 309-316. PMID: 20117435, PMCID: PMC2832791, DOI: 10.1016/j.jacc.2009.07.066.Peer-Reviewed Original ResearchConceptsLong-term mortalityGeriatric conditionsNet reclassification improvementMobility disabilityOlder patientsReclassification improvementRisk factorsMultivariable logistic regression modelHeart failure hospitalizationIndependent risk factorTraditional risk factorsMedical record dataFinal multivariable modelYears of ageLogistic regression modelsFailure hospitalizationTerm mortalityHeart failureIndependent predictorsPrognostic importanceMean ageMultivariable modelMedicare beneficiariesMortality rateSubsequent mortality