2023
Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration
MacLean RR, Eid T, Parida S, Gueorguieva R, DeVito EE, Sofuoglu M. Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration. Experimental And Clinical Psychopharmacology 2023, 31: 37-45. PMID: 35254839, PMCID: PMC9448824, DOI: 10.1037/pha0000556.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioDose of nicotineNicotine reinforcementSubjective effectsDiscriminative stimulus effectsHeart rate increaseDoses of nicotineSelf-administration procedureSubjective positive effectsDaily smokersBaseline cravingIntravenous nicotineOvernight abstinenceCigarette cravingDrug effectsMetabolite ratiosStimulus effectsSecondary analysisPlaceboSelf-AdministrationNicotine choiceTobacco productsNicotinePleasurable effectsYoung adults
2022
Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science
De Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology 2022, 27: e13161. PMID: 35229960, PMCID: PMC8903077, DOI: 10.1111/adb.13161.Peer-Reviewed Original ResearchConceptsAbuse potentialPositive subjective drug effectsSubjective drug effectsHuman laboratory studiesPositive subjective effectsAttention functionSmoking urgesOvernight abstinencePotential therapeutic effectsEffects of nicotineHeart rate increaseDelivery rateDependent smokersExperimental sessionsSubjective effectsNicotine dependenceIntravenous nicotineBlood pressureSaline infusionAcute effectsTherapeutic effectHeart rateDrug effectsAcute responseCrossover design
2021
Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers
MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers. Psychopharmacology 2021, 238: 2083-2090. PMID: 33796907, PMCID: PMC8715498, DOI: 10.1007/s00213-021-05833-8.Peer-Reviewed Original ResearchConceptsDose of nicotineNicotine reinforcementHigh doseSubjective effectsHuman laboratory studiesYoung adult smokersNicotine self-administration modelNon-dependent smokersOvernight nicotine abstinenceEffects modelSelf-administration modelSelf-administration procedureNicotine doseAdult smokersMethodsYoung adultsObjectivesThe current studyNicotine abstinenceNicotine addictionHigh dosesLow dosesPlaceboThreshold doseReinforcement thresholdTobacco productsDoseThe feasibility of an in‐scanner smoking lapse paradigm to examine the neural correlates of lapses
Lydon‐Staley D, MacLean RR, Falk EB, Bassett DS, Wilson SJ. The feasibility of an in‐scanner smoking lapse paradigm to examine the neural correlates of lapses. Addiction Biology 2021, 26: e13001. PMID: 33508880, PMCID: PMC8225575, DOI: 10.1111/adb.13001.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingFunctional brain systemsCognitive controlBrain systemsDefault mode systemLapse behaviorSmoking cessation attemptFrontoparietal systemNeural correlatesMonetary rewardsBehavioral paradigmsNeural activityInitial evidenceScanning sessionSmoking abstinenceCessation attemptsDaily smokersTime-varying changesSingle scanning sessionQuitting smokingBehavioral modelMagnetic resonance imagingAbstinenceParticipantsParadigm
2020
Co-Operative Pain Education and Self-management (COPES) Expanding Treatment for Real-World Access (ExTRA): Pragmatic Trial Protocol
Heapy AA, Driscoll MA, Buta E, LaChappelle KM, Edmond S, Krein SL, Piette JD, Mattocks K, Murphy JL, DeBar L, MacLean RR, Ankawi B, Kawecki T, Martino S, Wagner T, Higgins DM. Co-Operative Pain Education and Self-management (COPES) Expanding Treatment for Real-World Access (ExTRA): Pragmatic Trial Protocol. Pain Medicine 2020, 21: s21-s28. PMID: 33313733, PMCID: PMC7734659, DOI: 10.1093/pm/pnaa365.Peer-Reviewed Original ResearchConceptsCBT-CPMusculoskeletal painPragmatic trialInteractive voice responseHealth care system factorsPragmatic trial protocolChronic musculoskeletal painVA Medical CenterVeterans Affairs cliniciansDepression symptom severityBudget impact analysisReal-world accessCognitive behavioral therapySecondary outcomesPain intensityPrimary outcomeChronic painPain interferenceSuperiority trialGlobal ImpressionPain educationPatient preferencesTrial protocolMedical CenterReal-world settingPredictors of engagement in an internet-based cognitive behavioral therapy program for veterans with chronic low back pain
Solar C, Halat AM, MacLean RR, Rajeevan H, Williams DA, Krein SL, Heapy AA, Bair MJ, Kerns RD, Higgins DM. Predictors of engagement in an internet-based cognitive behavioral therapy program for veterans with chronic low back pain. Translational Behavioral Medicine 2020, 11: 1274-1282. PMID: 33098304, DOI: 10.1093/tbm/ibaa098.Peer-Reviewed Original ResearchConceptsChronic low back painLow back painClinical characteristicsBack painChronic painEASE programParticipant characteristicsInternet-based cognitive behavioural therapy programmeInternet-based cognitive behavioral therapy interventionInternet-based interventionsCognitive behavioral therapy interventionInternet-based programCognitive behavioral therapy programBehavioral therapy interventionBehavioral therapy programRace/ethnicityPain careMean ageNumber of loginsIncreased ageTherapy interventionWeek trialPainTherapy programPredictors of engagementNaturalistic measurement of dual cue attentional bias in moderate to heavy-drinking smokers: A preliminary investigation
MacLean RR, Sofuoglu M, Waters AJ. Naturalistic measurement of dual cue attentional bias in moderate to heavy-drinking smokers: A preliminary investigation. Drug And Alcohol Dependence 2020, 209: 107892. PMID: 32058247, DOI: 10.1016/j.drugalcdep.2020.107892.Peer-Reviewed Original ResearchConceptsAlcohol attentional biasAttentional biasAlcohol cuesAmbulatory assessmentPossible cognitive mechanismsTask four timesHeavy drinking smokersCognitive mechanismsCue typesDrug cuesPreferential attentionNaturalistic measurementsCuesAlcohol useDaily smokersSubject associationsLarge sampleDaily lifeBiasFurther researchFirst studyPreliminary investigationCravingHeavy amountsCigarettes
2018
Attentional bias in opioid users: A systematic review and meta-analysis
MacLean RR, Sofuoglu M, Brede E, Robinson C, Waters AJ. Attentional bias in opioid users: A systematic review and meta-analysis. Drug And Alcohol Dependence 2018, 191: 270-278. PMID: 30157467, DOI: 10.1016/j.drugalcdep.2018.07.012.Peer-Reviewed Original ResearchConceptsAttentional biasNeutral stimuliBehavioral treatmentRobust attentional biasAdjunctive behavioral treatmentsOpioid use disorderAttention biasOpioid cuesSalient stimuliEligible peer-reviewed studiesStimuliUse disordersOpioid usersCurrent studySystematic reviewPeer-reviewed studiesNational public health emergencyBiasComprehensive literature searchTreatment outcomesPublic health emergencyOpioid useActive responseCuesPrimary treatment
2017
Tobacco and alcohol use disorders: Evaluating multimorbidity
MacLean RR, Sofuoglu M, Rosenheck R. Tobacco and alcohol use disorders: Evaluating multimorbidity. Addictive Behaviors 2017, 78: 59-66. PMID: 29127785, DOI: 10.1016/j.addbeh.2017.11.006.Peer-Reviewed Original ResearchConceptsTobacco use disorderAlcohol use disorderVeterans Health AdministrationUse disordersConcurrent alcohol use disorderMental health outpatient servicesMental health disordersCo-occurring diagnosesCo-occurring conditionsHepatic diseaseUse of substancesOutpatient servicesService usePsychiatric diagnosisTreatment approachesHealth disordersDisability pensionHealth AdministrationSocio-environmental factorsAdverse effectsDiagnosisDisordersGreater likelihoodVeteransHigh rate