2017
The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family
Sun N, Nasello C, Deng L, Wang N, Zhang Y, Xu Z, Song Z, Kwan K, King R, Pang Z, Xing J, Heiman G, Tischfield J. The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. Molecular Psychiatry 2017, 23: 1487-1495. PMID: 28894297, PMCID: PMC5847395, DOI: 10.1038/mp.2017.179.Peer-Reviewed Original ResearchConceptsNonsense-mediated mRNA decayNonsense mutationMultiplex familiesPluripotent stem cellsTD phenotypeDeleterious sequence variantsGenetic architectureMRNA decayHouse bioinformatics pipelineDNA sequencesBioinformatics pipelineTD familyWhole-exome sequencingSequence variantsBiochemical assaysMolecular differencesWhole exomeIsoform levelsStem cellsProtein levelsTD etiologyExome sequencingPNKDHeterozygous nonsense mutationGenes
2012
Genome-wide association study of Tourette's syndrome
Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, Hardy J, Strengman E, Ophoff R, Wagner M, Moessner R, Mirel D, Posthuma D, Sabatti C, Eskin E, Conti D, Knowles J, Ruiz-Linares A, Rouleau G, Purcell S, Heutink P, Oostra B, McMahon W, Freimer N, Cox N, Pauls D. Genome-wide association study of Tourette's syndrome. Molecular Psychiatry 2012, 18: 721-728. PMID: 22889924, PMCID: PMC3605224, DOI: 10.1038/mp.2012.69.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttention Deficit Disorder with HyperactivityCase-Control StudiesChromosomes, Human, Pair 9FemaleFibrillar CollagensGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansInternational CooperationMaleMeta-Analysis as TopicObsessive-Compulsive DisorderPolymorphism, Single NucleotideTourette SyndromeWhite PeopleYoung AdultConceptsGenome-wide association studiesFirst genome-wide association studyAssociation studiesTop signalsFull genetic architectureAncestry-matched controlsEuropean ancestry samplesGenetic architectureGWAS dataComplex inheritanceEuropean-derived populationsSusceptibility variantsSusceptibility genesEventual identificationEuropean ancestryCosta RicaChromosome 9q32Familial recurrence rateNorth AmericaComplete understandingAmerican populationCentral ValleyNeuropsychiatric diseasesDevelopmental disordersGenes
2007
A Chronological Perspective on Suicide—The Last Days of Life
Orbach I, Gilboa-Schechtman E, Ofek H, Lubin G, Mark M, Bodner E, Cohen D, King R. A Chronological Perspective on Suicide—The Last Days of Life. Death Studies 2007, 31: 909-932. PMID: 17924514, DOI: 10.1080/07481180701603394.Peer-Reviewed Original Research
2001
Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders
Morshed S, Parveen S, Leckman J, Mercadante M, Kiss M, Miguel E, Arman A, Yazgan Y, Fujii T, Paul S, Peterson B, Zhang H, King R, Scahill L, Lombroso P. Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders. Biological Psychiatry 2001, 50: 566-577. PMID: 11690591, DOI: 10.1016/s0006-3223(01)01096-4.Peer-Reviewed Original ResearchConceptsTotal antinuclear antibodiesAntinuclear antibodiesAutoimmune disordersTourette syndromeAnticytoskeletal antibodiesAntineural antibodiesStreptococcal infectionT patientsTS patientsBeta-hemolytic streptococcal infectionPrior streptococcal infectionHemolytic streptococcal infectionAntistreptolysin O titerIndirect immunofluorescent assayLevels of immunoreactivityWestern blot techniqueMean rankClinical characteristicsSydenham's choreaO titerPatient groupSC patientsIgG antibodiesIgG classNormal controlsPsychosocial and Risk Behavior Correlates of Youth Suicide Attempts and Suicidal Ideation
KING R, SCHWAB-STONE M, FLISHER A, GREENWALD S, KRAMER R, GOODMAN S, LAHEY B, SHAFFER D, GOULD M. Psychosocial and Risk Behavior Correlates of Youth Suicide Attempts and Suicidal Ideation. Journal Of The American Academy Of Child & Adolescent Psychiatry 2001, 40: 837-846. PMID: 11437023, DOI: 10.1097/00004583-200107000-00019.Peer-Reviewed Original ResearchConceptsSuicidal ideationRisk behavior correlatesStressful life eventsCurrent smokingLow parental monitoringAdolescent Mental Disorders (MECA) StudySignificant associationRisk behaviorsPoor family environmentEpidemiology of ChildParental psychiatric historySexual activityMental Disorders StudyLife eventsNIMH MethodsPsychiatric historyPsychiatric disordersDisruptive disordersPhysical fightingBehavior correlatesSociodemographic characteristicsSuicide attemptsFamily environmentSociodemographic variablesSubject characteristicsCase control and family‐based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents
Zalsman G, Frisch A, King R, Pauls D, Grice D, Gelernter J, Alsobrook J, Michaelovsky E, Apter A, Tyano S, Weizman A, Leckman J. Case control and family‐based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents. American Journal Of Medical Genetics 2001, 105: 451-457. PMID: 11449398, DOI: 10.1002/ajmg.1406.Peer-Reviewed Original ResearchConceptsSuicidal behaviorSuicide riskA218C polymorphismDetailed clinical historyHaplotype relative riskAssociation of suicidalityTransmission disequilibrium test (TDT) methodsTryptophan hydroxylase geneAdolescent suicidal behaviorClinical historySame ethnic populationRelative riskCase controlAA genotypeControl groupFamily-based studySuicide intentSignificant allelic associationSignificant differencesEthnic populationsStructured interviewsInpatient adolescentsRiskAssociationSuicidality
2000
Risk Behavior in a Community Sample of Children and Adolescents
FLISHER A, KRAMER R, HOVEN C, KING R, BIRD H, DAVIES M, GOULD M, GREENWALD S, LAHEY B, REGIER D, SCHWAB-STONE M, SHAFFER D. Risk Behavior in a Community Sample of Children and Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 2000, 39: 881-887. PMID: 10892230, DOI: 10.1097/00004583-200007000-00017.Peer-Reviewed Original ResearchConceptsRisk behaviorsFunctional impairmentAdolescent Mental Disorders (MECA) StudyFamily psychiatric disordersEpidemiology of ChildMental Disorders StudySuicidal ideation/attemptsPotential correlatesCigarette smokingOdds ratioCommunity probability sampleMarijuana smokingPsychiatric disordersLinear regression analysisAlcohol useDisorders StudySmokingRegression analysisChildrenCommunity sampleProbability sampleAdolescentsImpairmentPsychopathologySignificant relationship
1998
Psychopathology Associated With Suicidal Ideation and Attempts Among Children and Adolescents
GOULD M, KING R, GREENWALD S, FISHER P, SCHWAB-STONE M, KRAMER R, FLISHER A, GOODMAN S, CANINO G, SHAFFER D. Psychopathology Associated With Suicidal Ideation and Attempts Among Children and Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 915-923. PMID: 9735611, DOI: 10.1097/00004583-199809000-00011.Peer-Reviewed Original ResearchConceptsSubstance abuse/dependenceAbuse/dependenceSuicidal ideationSuicide attemptsPsychiatric disordersSubstance abuse/dependence disordersAdolescent Mental Disorders (MECA) StudySuicide riskNoncriterion symptomsChildren Version 2.3Epidemiology of ChildAge-specific riskDiagnostic Interview ScheduleMental Disorders StudyLogistic regression analysisDependence disordersDisruptive disordersPanic attacksSignificant independent contributionSociodemographic characteristicsRisk profileSuicidal thoughtsSpecific disordersSuicide attemptersSymptom correlatesOBSESSIVE-COMPULSIVE DISORDER AND SEPARATION ANXIETY
Martin A, Scahill L, Vitulano L, King R. OBSESSIVE-COMPULSIVE DISORDER AND SEPARATION ANXIETY. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 350-351. PMID: 9549953, DOI: 10.1097/00004583-199804000-00010.Peer-Reviewed Original Research
1997
Thresholds and Tolerance of Physical Pain in Suicidal and Nonsuicidal Adolescents
Orbach I, Mikulincer M, King R, Cohen D, Stein D. Thresholds and Tolerance of Physical Pain in Suicidal and Nonsuicidal Adolescents. Journal Of Consulting And Clinical Psychology 1997, 65: 646-652. PMID: 9256566, DOI: 10.1037/0022-006x.65.4.646.Peer-Reviewed Original ResearchChildren's Yale-Brown Obsessive Compulsive Scale: Reliability and Validity
Scahill L, Riddle M, McSwiggin-Hardin M, Ort S, King R, Goodman W, Cicchetti D, Leckman J. Children's Yale-Brown Obsessive Compulsive Scale: Reliability and Validity. Journal Of The American Academy Of Child & Adolescent Psychiatry 1997, 36: 844-852. PMID: 9183141, DOI: 10.1097/00004583-199706000-00023.Peer-Reviewed Original ResearchConceptsChildren's Yale-Brown Obsessive Compulsive ScaleYale-Brown Obsessive Compulsive ScaleObsessive-compulsive disorderObsessive-compulsive symptom severityManifest Anxiety ScaleObsessive-compulsive symptomsObsessive Compulsive ScaleChildren's Manifest Anxiety ScaleCompulsive ScaleCY-BOCS total scoreSymptom severityDepression InventoryChildren's Depression InventoryTotal scoreCY-BOCS scoresAnxiety ScaleConvergent validityValid subscalesInternal consistencyCompulsion scoreAdolescentsSubscalesChildrenInterrater agreementValidityRitual, Habit, and Perfectionism: The Prevalence and Development of Compulsive‐like Behavior in Normal Young Children
Evans D, Leckman J, Carter A, Reznick J, Henshaw D, King R, Pauls D. Ritual, Habit, and Perfectionism: The Prevalence and Development of Compulsive‐like Behavior in Normal Young Children. Child Development 1997, 68: 58-68. PMID: 9084125, DOI: 10.1111/j.1467-8624.1997.tb01925.x.Peer-Reviewed Original Research
1996
Risk Factors for Presenting Problems in Child Psychiatric Emergencies
PETERSON B, ZHANG H, SANTA LUCIA R, KING R, LEWIS M. Risk Factors for Presenting Problems in Child Psychiatric Emergencies. Journal Of The American Academy Of Child & Adolescent Psychiatry 1996, 35: 1162-1173. PMID: 8824060, DOI: 10.1097/00004583-199609000-00014.Peer-Reviewed Original ResearchConceptsRisk factorsEmergency roomPsychiatric emergenciesSuicide attemptsChild psychiatric emergenciesIndependent risk factorEmergency room visitsSimilar risk factorsHospitalization of childrenDemographic risk factorsYears of agePsychiatric emergency roomHospital emergency roomSubset of childrenStrength of associationAggressive presentationInitial visitMale sexRoom visitsSuicidal ideatorsSuicidal ideationYounger ageFuture suicidalityPsychiatric subjectsHospitalizationObsessive-Compulsive Characteristics: From Symptoms to Syndrome
APTER A, FALLON T, KING R, RATZONI G, ZOHAR A, BINDER M, WEIZMAN A, LECKMAN J, PAULS D, KRON S, COHEN D. Obsessive-Compulsive Characteristics: From Symptoms to Syndrome. Journal Of The American Academy Of Child & Adolescent Psychiatry 1996, 35: 907-912. PMID: 8768350, DOI: 10.1097/00004583-199607000-00016.Peer-Reviewed Original ResearchBehavioral Therapy in Children and Adolescents with Obsessive-Compulsive Disorder: A Pilot Study
Scahill L, Vitulano L, Brenner E, Lynch K, King R. Behavioral Therapy in Children and Adolescents with Obsessive-Compulsive Disorder: A Pilot Study. Journal Of Child And Adolescent Psychopharmacology 1996, 6: 191-202. PMID: 9231312, DOI: 10.1089/cap.1996.6.191.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleBehavioral treatmentBehavioral therapyRandomized clinical trialsTreatment of childrenChildren's Yale-Brown Obsessive Compulsive ScaleBehavioral therapy programObsessive Compulsive ScaleMedication treatmentPrimary diagnosisMonths posttreatmentClinical trialsTreatment endpointBooster sessionsDose reductionDose requirementsMedicationsUseful adjunctTherapeutic gainTreatment programTherapy programPilot studyCompulsive ScaleTreatment
1995
Childhood Trichotillomania: Clinical Phenomenology, Comorbidity, and Family Genetics
KING R, SCAHILL L, VITULANO L, SCHWAB-STONE M, TERCYAK K, RIDDLE M. Childhood Trichotillomania: Clinical Phenomenology, Comorbidity, and Family Genetics. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1451-1459. PMID: 8543512, DOI: 10.1097/00004583-199511000-00011.Peer-Reviewed Original ResearchRisperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report
LOMBROSO P, SCAHILL L, KING R, LYNCH K, CHAPPELL P, PETERSON B, McDOUGLE C, LECKMAN J. Risperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1147-1152. PMID: 7559308, DOI: 10.1097/00004583-199509000-00011.Peer-Reviewed Original ResearchConceptsChronic tic disorderTic disordersObsessive-compulsive disorderChronic motor tic disorderYale Global Tic Severity ScaleDopamine-blocking propertiesOpen-label trialFrequent side effectsEfficacy of risperidoneMotor tic disorderShort-term safetyTic Severity ScaleComorbid obsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleClinical responseRisperidone treatmentMean ageTic scoreSeverity ScaleSide effectsTourette syndromeComorbid diagnosesTic frequencyWeight gainAn Epidemiological Study of Trichotillomania in Israeli Adolescents
KING R, ZOHAR A, RATZONI G, BINDER M, KRON S, DYCIAN A, COHEN D, PAULS D, APTER A. An Epidemiological Study of Trichotillomania in Israeli Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1212-1215. PMID: 7559316, DOI: 10.1097/00004583-199509000-00019.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsComorbid psychopathologyPrevalence of trichotillomaniaSignificant obsessive-compulsive symptomsObsessive-compulsive disorderLifetime prevalenceVocal ticsComorbid disordersEpidemiological studiesPrevalenceAnxiety disordersPhysical fitnessSubsequent reliefTrichotillomaniaCommunity adolescent sampleDisordersSymptomsElevated ratesOverall competencySubjectsAdolescentsReliefPsychopathologyBald spotsIsraeli adolescents
1994
Steroid Hormones and Tourette's Syndrome
PETERSON B, LECKMAN J, SCAHILL L, NAFTOLIN F, KEEFE D, CHAREST N, KING R, HARDIN M, COHEN D. Steroid Hormones and Tourette's Syndrome. Journal Of Clinical Psychopharmacology 1994, 14: 131-135. PMID: 8195454, DOI: 10.1097/00004714-199404000-00008.Peer-Reviewed Original ResearchFluvoxamine Open-Label Treatment of Adolescent Inpatients with Obsessive-Compulsive Disorder or Depression
APTER A, RATZONI G, KING R, WEIZMAN A, IANCU I, BINDER M, RIDDLE M. Fluvoxamine Open-Label Treatment of Adolescent Inpatients with Obsessive-Compulsive Disorder or Depression. Journal Of The American Academy Of Child & Adolescent Psychiatry 1994, 33: 342-348. PMID: 8169178, DOI: 10.1097/00004583-199403000-00007.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMajor depressive disorderYale-Brown Obsessive Compulsive ScaleOvert Aggression ScaleBeck Depression InventorySide effectsSuicide Potential ScaleSpecific serotonin uptake inhibitorAdolescent inpatientsEfficacy of fluvoxamineOpen-label trialOpen-label treatmentCommon side effectsSerotonin uptake inhibitorSerious side effectsShort-term treatmentY-BOCS scoresObsessive Compulsive ScaleDaily dosesTarget symptomsDepressive disorderDemonstrated efficacyInvestigational basisUptake inhibitorFluvoxamine