2017
Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome
Hirschtritt M, Darrow S, Illmann C, Osiecki L, Grados M, Sandor P, Dion Y, King R, Pauls D, Budman C, Cath D, Greenberg E, Lyon G, Yu D, McGrath L, McMahon W, Lee P, Delucchi K, Scharf J, Mathews C. Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome. Psychological Medicine 2017, 48: 279-293. PMID: 28651666, PMCID: PMC7909616, DOI: 10.1017/s0033291717001672.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityFamilyHumansObsessive-Compulsive DisorderPhenotypeTourette SyndromeConceptsAttention-deficit/hyperactivity disorderSymmetry/exactnessTourette syndromeLatent class analysisSymptom patternsADHD symptomsHigher psychiatric comorbidity ratesPsychiatric comorbidity ratesExploratory factor analysisHyperactive subtypeComorbidity ratesTS patientsClinical relevanceSpecific subtypesSum scoreUnique phenotypicHyperactivity disorderSymptomsPhenotypic overlapThree-class solutionTraditional diagnostic boundariesAggressive urgesSyndromeSubtypesDiagnostic boundaries
2012
Genome-wide association study of Tourette's syndrome
Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, Hardy J, Strengman E, Ophoff R, Wagner M, Moessner R, Mirel D, Posthuma D, Sabatti C, Eskin E, Conti D, Knowles J, Ruiz-Linares A, Rouleau G, Purcell S, Heutink P, Oostra B, McMahon W, Freimer N, Cox N, Pauls D. Genome-wide association study of Tourette's syndrome. Molecular Psychiatry 2012, 18: 721-728. PMID: 22889924, PMCID: PMC3605224, DOI: 10.1038/mp.2012.69.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttention Deficit Disorder with HyperactivityCase-Control StudiesChromosomes, Human, Pair 9FemaleFibrillar CollagensGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansInternational CooperationMaleMeta-Analysis as TopicObsessive-Compulsive DisorderPolymorphism, Single NucleotideTourette SyndromeWhite PeopleYoung AdultConceptsGenome-wide association studiesFirst genome-wide association studyAssociation studiesTop signalsFull genetic architectureAncestry-matched controlsEuropean ancestry samplesGenetic architectureGWAS dataComplex inheritanceEuropean-derived populationsSusceptibility variantsSusceptibility genesEventual identificationEuropean ancestryCosta RicaChromosome 9q32Familial recurrence rateNorth AmericaComplete understandingAmerican populationCentral ValleyNeuropsychiatric diseasesDevelopmental disordersGenes
1998
STIMULANT USE AND TRICHOTILLOMANIA
Martin A, Scahill L, Vitulano L, King R. STIMULANT USE AND TRICHOTILLOMANIA. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 349-350. PMID: 9549952, DOI: 10.1097/00004583-199804000-00009.Peer-Reviewed Original ResearchAdolescentAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildFemaleHumansMethylphenidateTrichotillomania
1995
Risperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report
LOMBROSO P, SCAHILL L, KING R, LYNCH K, CHAPPELL P, PETERSON B, McDOUGLE C, LECKMAN J. Risperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1147-1152. PMID: 7559308, DOI: 10.1097/00004583-199509000-00011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntipsychotic AgentsAttention Deficit Disorder with HyperactivityChildChronic DiseaseDose-Response Relationship, DrugFemaleHumansMaleObsessive-Compulsive DisorderPilot ProjectsRisperidoneSeverity of Illness IndexTic DisordersTourette SyndromeWeight GainConceptsChronic tic disorderTic disordersObsessive-compulsive disorderChronic motor tic disorderYale Global Tic Severity ScaleDopamine-blocking propertiesOpen-label trialFrequent side effectsEfficacy of risperidoneMotor tic disorderShort-term safetyTic Severity ScaleComorbid obsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleClinical responseRisperidone treatmentMean ageTic scoreSeverity ScaleSide effectsTourette syndromeComorbid diagnosesTic frequencyWeight gainAn Epidemiological Study of Trichotillomania in Israeli Adolescents
KING R, ZOHAR A, RATZONI G, BINDER M, KRON S, DYCIAN A, COHEN D, PAULS D, APTER A. An Epidemiological Study of Trichotillomania in Israeli Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1212-1215. PMID: 7559316, DOI: 10.1097/00004583-199509000-00019.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetAttention Deficit Disorder with HyperactivityFemaleHumansIncidenceIsraelMaleObsessive-Compulsive DisorderPrevalencePsychiatric Status Rating ScalesTrichotillomaniaConceptsObsessive-compulsive symptomsComorbid psychopathologyPrevalence of trichotillomaniaSignificant obsessive-compulsive symptomsObsessive-compulsive disorderLifetime prevalenceVocal ticsComorbid disordersEpidemiological studiesPrevalenceAnxiety disordersPhysical fitnessSubsequent reliefTrichotillomaniaCommunity adolescent sampleDisordersSymptomsElevated ratesOverall competencySubjectsAdolescentsReliefPsychopathologyBald spotsIsraeli adolescents
1991
Sudden Death in Children Receiving Norpramin®: A Review of Three Reported Cases and Commentary
RIDDLE M, NELSON J, KLEINMAN C, RASMUSSON A, LECKMAN J, KING R, COHEN D. Sudden Death in Children Receiving Norpramin®: A Review of Three Reported Cases and Commentary. Journal Of The American Academy Of Child & Adolescent Psychiatry 1991, 30: 104-108. PMID: 2005044, DOI: 10.1097/00004583-199101000-00016.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityChildDeath, SuddenDepressive DisorderDesipramineHeart ArrestHumansMaleRisk FactorsVentricular Fibrillation