2024
The Challenge of Examining Social Determinants of Health in People Living With Tourette Syndrome
Dy-Hollins M, Carr S, Essa A, Osiecki L, Lackland D, Voeks J, Mejia N, Sharma N, Budman C, Cath D, Grados M, King R, Lyon G, Rouleau G, Sandor P, Singer H, Chibnik L, Mathews C, Scharf J. The Challenge of Examining Social Determinants of Health in People Living With Tourette Syndrome. Pediatric Neurology 2024, 155: 55-61. PMID: 38608551, PMCID: PMC11132913, DOI: 10.1016/j.pediatrneurol.2024.02.008.Peer-Reviewed Original ResearchParental educational attainmentEthnic minority groupsEducational attainmentSocial determinants of healthExamining social determinants of healthNon-Hispanic White individualsDeterminants of healthDiagnosis ageNon-Hispanic whitesMinority groupsHispanic individualsWhite individualsSignificant disparitiesLogistic regressionParental educationNon-whiteComorbid conditionsNon-parametric testsEthnicityGroup differencesSymptom onsetOutcomesParticipantsResearch studiesTourette syndrome
2022
Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids
Brady M, Mariani J, Koca Y, Szekely A, King R, Bloch M, Landeros-Weisenberger A, Leckman J, Vaccarino F. Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids. Molecular Psychiatry 2022, 27: 5007-5019. PMID: 36447010, PMCID: PMC9949887, DOI: 10.1038/s41380-022-01880-5.Peer-Reviewed Original ResearchConceptsTourette syndromeInterneuron deficitsGABAergic interneuronsHealthy controlsNeurodevelopmental underpinningsNeuropathological deficitsBG circuitryNeuropsychiatric disordersDecreased differentiationT patientsInterneuronsAltered expressionPotential mechanismsCilia disruptionSonic hedgehogOrganoidsStem cellsTS individualsPluripotent stem cellsGli transcription factorsDeficitsOrganoid differentiationEarly stagesCholinergicPatientsPhenomenology of Tics and Sensory Urges
Leckman J, Bloch M, Sukhodolsky D, Artukoğlu B, Scahill L, King R. Phenomenology of Tics and Sensory Urges. 2022, 6-25. DOI: 10.1093/med/9780197543214.003.0002.Peer-Reviewed Original Research
2017
Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome
Hirschtritt M, Darrow S, Illmann C, Osiecki L, Grados M, Sandor P, Dion Y, King R, Pauls D, Budman C, Cath D, Greenberg E, Lyon G, Yu D, McGrath L, McMahon W, Lee P, Delucchi K, Scharf J, Mathews C. Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome. Psychological Medicine 2017, 48: 279-293. PMID: 28651666, PMCID: PMC7909616, DOI: 10.1017/s0033291717001672.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderSymmetry/exactnessTourette syndromeLatent class analysisSymptom patternsADHD symptomsHigher psychiatric comorbidity ratesPsychiatric comorbidity ratesExploratory factor analysisHyperactive subtypeComorbidity ratesTS patientsClinical relevanceSpecific subtypesSum scoreUnique phenotypicHyperactivity disorderSymptomsPhenotypic overlapThree-class solutionTraditional diagnostic boundariesAggressive urgesSyndromeSubtypesDiagnostic boundaries
2013
Phenomenology of Tics and Sensory Urges: The Self Under Siege
Leckman J, Bloch M, Sukhodolsky D, Scahill L, King R. Phenomenology of Tics and Sensory Urges: The Self Under Siege. 2013, 3-25. DOI: 10.1093/med/9780199796267.003.0001.Peer-Reviewed Original ResearchAcademic outcomesComorbid behavioral problemsNovel behavioral interventionKey phenomenological featuresCognitive domainsIrrelevant informationBehavioral problemsBehavioral interventionsPhenomenology of ticsTourette syndromeLong-term outcomesPhenomenological featuresTic expressionTic disordersEnvironmental contextReduced abilitySensory urgeOutside worldRelated disordersEducational objectivesPhenomenological spectrum
2005
Tourette’s Syndrome and Tic Disorders
Swain J, King R, Leckman J. Tourette’s Syndrome and Tic Disorders. Current Clinical Neurology 2005, 151-169. DOI: 10.1385/1-59259-856-0:151.Peer-Reviewed Original Research
2001
Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders
Morshed S, Parveen S, Leckman J, Mercadante M, Kiss M, Miguel E, Arman A, Yazgan Y, Fujii T, Paul S, Peterson B, Zhang H, King R, Scahill L, Lombroso P. Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders. Biological Psychiatry 2001, 50: 566-577. PMID: 11690591, DOI: 10.1016/s0006-3223(01)01096-4.Peer-Reviewed Original ResearchConceptsTotal antinuclear antibodiesAntinuclear antibodiesAutoimmune disordersTourette syndromeAnticytoskeletal antibodiesAntineural antibodiesStreptococcal infectionT patientsTS patientsBeta-hemolytic streptococcal infectionPrior streptococcal infectionHemolytic streptococcal infectionAntistreptolysin O titerIndirect immunofluorescent assayLevels of immunoreactivityWestern blot techniqueMean rankClinical characteristicsSydenham's choreaO titerPatient groupSC patientsIgG antibodiesIgG classNormal controls
2000
Contemporary approaches to the treatment of tics in Tourette syndrome
Scahill L, King R, Leckman J, Harris N. Contemporary approaches to the treatment of tics in Tourette syndrome. Brazilian Journal Of Psychiatry 2000, 22: 189-193. DOI: 10.1590/s1516-44462000000400010.Peer-Reviewed Original Research
1995
Risperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report
LOMBROSO P, SCAHILL L, KING R, LYNCH K, CHAPPELL P, PETERSON B, McDOUGLE C, LECKMAN J. Risperidone Treatment of Children and Adolescents with Chronic Tic Disorders: A Preliminary Report. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1147-1152. PMID: 7559308, DOI: 10.1097/00004583-199509000-00011.Peer-Reviewed Original ResearchConceptsChronic tic disorderTic disordersObsessive-compulsive disorderChronic motor tic disorderYale Global Tic Severity ScaleDopamine-blocking propertiesOpen-label trialFrequent side effectsEfficacy of risperidoneMotor tic disorderShort-term safetyTic Severity ScaleComorbid obsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleClinical responseRisperidone treatmentMean ageTic scoreSeverity ScaleSide effectsTourette syndromeComorbid diagnosesTic frequencyWeight gain
1994
Steroid Hormones and Tourette's Syndrome
PETERSON B, LECKMAN J, SCAHILL L, NAFTOLIN F, KEEFE D, CHAREST N, KING R, HARDIN M, COHEN D. Steroid Hormones and Tourette's Syndrome. Journal Of Clinical Psychopharmacology 1994, 14: 131-135. PMID: 8195454, DOI: 10.1097/00004714-199404000-00008.Peer-Reviewed Original Research
1990
Fluoxetine Treatment of Children and Adolescents with Tourette's and Obsessive Compulsive Disorders: Preliminary Clinical Experience
RIDDLE M, HARDIN M, KING R, SCAHILL L, WOOLSTON J. Fluoxetine Treatment of Children and Adolescents with Tourette's and Obsessive Compulsive Disorders: Preliminary Clinical Experience. Journal Of The American Academy Of Child & Adolescent Psychiatry 1990, 29: 45-48. PMID: 2295577, DOI: 10.1097/00004583-199001000-00008.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPreliminary clinical experiencePrimary obsessive-compulsive disorderTourette syndromeClinical experienceSelective serotonin uptake inhibitorMild gastrointestinal symptomsSerotonin uptake inhibitorEfficacy of fluoxetineCompulsive disorderFluoxetine administrationGastrointestinal symptomsFluoxetine treatmentResponder rateUptake inhibitorFluoxetineObsessive-compulsive symptomsPatientsAdverse effectsFluoxetine hydrochlorideSyndromeChildrenSymptomsOCD groupAdolescents