2001
Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo
Hartlapp I, Abe R, Saeed R, Peng T, Voelter W, Bucala R, Metz C. Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo. The FASEB Journal 2001, 15: 2215-2224. PMID: 11641248, DOI: 10.1096/fj.01-0049com.Peer-Reviewed Original ResearchConceptsBlood vessel formationAngiogenic phenotypeVessel formationMesenchymal cell typesEndothelial cell invasionEndothelial cellsExtracellular matrix-degrading enzymesEndothelial cell migrationGrowth factorCellular microenvironmentMatrix-degrading enzymesCell invasionCell migrationCell typesCultured endothelial cellsTube formationHematopoietic growth factorsPromotion of angiogenesisPhenotypeAngiogenesis modelMicrovascular endothelial cellsCultured fibrocytesEnzymeAngiogenesisVivoPeripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites
Abe R, Donnelly S, Peng T, Bucala R, Metz C. Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites. The Journal Of Immunology 2001, 166: 7556-7562. PMID: 11390511, DOI: 10.4049/jimmunol.166.12.7556.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood CellsCell DifferentiationCell MovementCells, CulturedCollagenFemaleFibroblastsFibrosisGelsHumansInjections, IntravenousLipopolysaccharide ReceptorsMiceMice, Inbred BALB CReceptors, ChemokineStem Cell TransplantationStem CellsTransforming Growth Factor betaTransforming Growth Factor beta1Wound HealingConceptsCultured fibrocytesTissue injuryChemokine/chemokine receptor interactionsUnique cell surface phenotypeCutaneous tissue injurySecondary lymphoid chemokineAlpha-smooth muscle actinWound healingWound healing myofibroblastsMononuclear cell populationsCCR7 chemokine receptorChemokine receptor interactionsPotent immunostimulatory activitySmooth muscle actinCell surface phenotypeBlood-borne cellsDifferentiation pathwayFibrocyte traffickingLymphoid chemokinesFibrocyte differentiationChemokine receptorsT cellsSurface phenotypePotent stimulusMuscle actinRegulation of the CTL Response by Macrophage Migration Inhibitory Factor
Abe R, Peng T, Sailors J, Bucala R, Metz C. Regulation of the CTL Response by Macrophage Migration Inhibitory Factor. The Journal Of Immunology 2001, 166: 747-753. PMID: 11145646, DOI: 10.4049/jimmunol.166.2.747.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAdoptive TransferAnimalsAntibodies, MonoclonalCD8-Positive T-LymphocytesCell MovementCells, CulturedCytotoxicity Tests, ImmunologicCytotoxicity, ImmunologicFemaleInjections, IntraperitonealLymphocytes, Tumor-InfiltratingMacrophage Migration-Inhibitory FactorsMiceMice, Inbred C57BLNeoplasm TransplantationT-Lymphocytes, CytotoxicThymomaTumor Cells, CulturedConceptsMacrophage migration inhibitory factorMigration inhibitory factorTumor-bearing miceCTL activityCTL responsesT lymphocytesAnti-tumor T lymphocytesInhibitory factorCultures of splenocytesApoptotic tumor cellsT cell survivalIL-2RPivotal cytokineT cellsHistological examinationImmune responseIFN-gammaSplenocyte culturesAg stimulationMouse modelTumor growthTumor tissueTumor cellsMiceElevated expression
2000
De Novo Expression of Macrophage Migration Inhibitory Factor in Atherogenesis in Rabbits
Lin S, Yu X, Chen Y, Huang X, Metz C, Bucala R, Lau C, Lan H. De Novo Expression of Macrophage Migration Inhibitory Factor in Atherogenesis in Rabbits. Circulation Research 2000, 87: 1202-1208. PMID: 11110779, DOI: 10.1161/01.res.87.12.1202.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorUpregulation of MIFSmooth muscle cellsVascular endothelial cellsMIF expressionMigration inhibitory factorFatty streak lesion formationInhibitory factorAbility of MIFIntercellular adhesion molecule-1 expressionAdhesion molecule-1 expressionFoam cell-rich lesionsNew Zealand white rabbitsAccumulation of macrophagesMolecule-1 expressionTranscriptase-polymerase chain reactionHypercholesterolemic rabbit modelEarly fatty streaksZealand white rabbitsDe novo expressionMacrophage-mediated diseasesMIF levelsCholesterol dietMIF mRNANormal dietThe proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle
Benigni F, Atsumi T, Calandra T, Metz C, Echtenacher B, Peng T, Bucala R. The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle. Journal Of Clinical Investigation 2000, 106: 1291-1300. PMID: 11086030, PMCID: PMC381433, DOI: 10.1172/jci9900.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell MovementFructosediphosphatesGlucoseGlycolysisHumansLactic AcidLiverMacrophage Migration-Inhibitory FactorsMacrophagesMiceMusclesPhosphofructokinase-2Phosphoric Monoester HydrolasesPhosphotransferases (Alcohol Group Acceptor)RatsTumor Cells, CulturedTumor Necrosis Factor-alphaConceptsMacrophage migration inhibitory factorMigration inhibitory factorTNF-alphaInhibitory factorTNF-alpha knockout miceMediator macrophage migration inhibitory factorAddition of MIFSystemic inflammatory responseSevere metabolic derangementProinflammatory cytokine productionSerum glucose levelsImmune cell activationAnterior pituitary glandPositive allosteric regulatorMetabolic derangementsAutocrine stimuliCytokine productionGlucose disposalImmune cellsSevere infectionsCatabolic effectsInflammatory responseGlucose levelsInsulin releaseCatabolic response
1998
Filarial Nematode Parasites Secrete a Homologue of the Human Cytokine Macrophage Migration Inhibitory Factor
Pastrana D, Raghavan N, FitzGerald P, Eisinger S, Metz C, Bucala R, Schleimer R, Bickel C, Scott A. Filarial Nematode Parasites Secrete a Homologue of the Human Cytokine Macrophage Migration Inhibitory Factor. Infection And Immunity 1998, 66: 5955-5963. PMID: 9826378, PMCID: PMC108754, DOI: 10.1128/iai.66.12.5955-5963.1998.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorCytokine macrophage migration inhibitory factorMonocytes/macrophagesMigration inhibitory factorHuman monocytes/macrophagesExcretory-secretory productsInhibitory factorProinflammatory cytokine macrophage migration inhibitory factorParasite excretory-secretory productsMurine macrophage migration inhibitory factorLong-term chronic infectionsMonocyte/macrophage migrationHost immune responseHuman macrophage migration inhibitory factorFilarial nematode parasitesTh2 responsesTh2 biasAntiparasite immunityChronic infectionImmunological environmentFilarial antigenImmune responseUterine wallCytokine homologuesMacrophage migration
1997
The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ
Chesney J, Bacher M, Bender A, Bucala R. The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6307-6312. PMID: 9177213, PMCID: PMC21045, DOI: 10.1073/pnas.94.12.6307.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen-Presenting CellsAntigens, CDCell DifferentiationCell MovementCells, CulturedCicatrixCoculture TechniquesCrosses, GeneticFemaleFibroblastsFlow CytometryHIVHIV Core Protein p24HIV Envelope Protein gp120HLA-DR AntigensHumansImmunophenotypingLymphocyte ActivationMaleMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred DBANeutralization TestsSkinT-LymphocytesConceptsNaive T cellsAntigen presentationT cellsHuman fibrocytesDistinct cell surface phenotypePrime naive T cellsPotent antigen-presenting cellsMajor histocompatability complex (MHC) moleculesAdhesion molecules CD11aAntigen-specific immunityProximal lymph nodesPeripheral blood fibrocytesAntigen-presenting cellsCostimulatory molecules CD80T cell proliferationCell surface phenotypeBlood-borne cellsHIV protein p24Dendritic cellsLymph nodesBlood fibrocytesPotent APCsTissue injurySurface phenotypeCutaneous injury