2021
Deletion of Cdh16 Ksp-cadherin leads to a developmental delay in the ability to maximally concentrate urine in mouse
Thomson R, Dynia DW, Burlein S, Thomson BR, Booth C, Knauf F, Wang T, Aronson P. Deletion of Cdh16 Ksp-cadherin leads to a developmental delay in the ability to maximally concentrate urine in mouse. American Journal Of Physiology. Renal Physiology 2021, 320: f1106-f1122. PMID: 33938239, PMCID: PMC8285649, DOI: 10.1152/ajprenal.00556.2020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAquaporin 2CadherinsGene Expression Regulation, DevelopmentalKidneyKidney Concentrating AbilityMaleMiceMice, KnockoutSodium-Potassium-Exchanging ATPaseConceptsKsp-cadherinCell adhesion moleculeAtypical memberKidney developmentMammalian kidneyAdult mammalian kidneyBasolateral membraneNormal kidney developmentEpithelial cellsAdhesion moleculesMutant animalsExpression analysisSpecific expressionE-cadherin expressionWestern blot analysisEpithelial phenotypePrincipal proteinE-cadherinBlot analysisMouse linesAquaporin-2CadherinCritical roleDevelopmental delayKnockout mice
2011
Effects of pH on Potassium: New Explanations for Old Observations
Aronson PS, Giebisch G. Effects of pH on Potassium: New Explanations for Old Observations. Journal Of The American Society Of Nephrology 2011, 22: 1981-1989. PMID: 21980112, PMCID: PMC3231780, DOI: 10.1681/asn.2011040414.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAcid-Base EquilibriumAcidosisAnimalsHomeostasisHumansHydrogen-Ion ConcentrationHyperkalemiaKidneyMuscle, SkeletalPotassiumPotassium ChannelsSodium-Hydrogen ExchangersSodium-Potassium-Exchanging ATPase
2003
Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD
Thomson RB, Mentone S, Kim R, Earle K, Delpire E, Somlo S, Aronson PS. Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD. American Journal Of Physiology. Renal Physiology 2003, 285: f870-f880. PMID: 12851251, DOI: 10.1152/ajprenal.00153.2003.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAnimalsCadherinsDisease Models, AnimalEpitheliumGene SilencingImmunohistochemistryKidneyMiceMicroscopy, ElectronMicroscopy, Electron, ScanningPolycystic Kidney, Autosomal DominantProtein Kinase D2Protein KinasesSodium-Potassium-Chloride SymportersSodium-Potassium-Exchanging ATPaseSolute Carrier Family 12, Member 2Tissue DistributionConceptsCell polarityKsp-cadherinBasolateral membraneRenal cystic epitheliaEpithelial cell polarityEpithelial cellsSpecific membrane proteinsCell dedifferentiationEpithelial cell dedifferentiationE-cadherinRenal epithelial cellsCystic epithelial cellsMembrane proteinsPhenotypic transitionCl(-) cotransporter NKCC1Expression levelsATPaseSecretory isoformEarly cystsTransepithelial secretionImmunocytochemical analysisUltrastructural analysisAutosomal dominant polycystic kidney diseaseDominant polycystic kidney diseasePolycystic kidney disease
1991
Increased Na(+)-H+ antiporter activity in apical membrane vesicles from mutant LLC-PK1 cells
Reilly RF, Haggerty JG, Aronson PS, Adelberg EA, Slayman CW. Increased Na(+)-H+ antiporter activity in apical membrane vesicles from mutant LLC-PK1 cells. American Journal Of Physiology 1991, 260: c738-c744. PMID: 1673319, DOI: 10.1152/ajpcell.1991.260.4.c738.Peer-Reviewed Original Research
1986
Properties and physiologic roles of the plasma membrane sodium-hydrogen exchanger.
Seifter JL, Aronson PS. Properties and physiologic roles of the plasma membrane sodium-hydrogen exchanger. Journal Of Clinical Investigation 1986, 78: 859-864. PMID: 3020091, PMCID: PMC423701, DOI: 10.1172/jci112671.Commentaries, Editorials and Letters
1985
The plasma membrane sodium-hydrogen exchanger and its role in physiological and pathophysiological processes.
Mahnensmith RL, Aronson PS. The plasma membrane sodium-hydrogen exchanger and its role in physiological and pathophysiological processes. Circulation Research 1985, 56: 773-788. PMID: 2988813, DOI: 10.1161/01.res.56.6.773.Commentaries, Editorials and LettersMeSH KeywordsAcid-Base EquilibriumAnimalsBiological Transport, ActiveBlood PlateletsCalciumCarrier ProteinsCations, MonovalentCell MembraneEpitheliumHormonesHumansHydrogenHydrogen-Ion ConcentrationHypertensionLeukocytesMembrane ProteinsNeoplasmsSodiumSodium-Hydrogen ExchangersSodium-Potassium-Exchanging ATPaseWater-Electrolyte BalanceConceptsSodium-hydrogen exchangerCellular acid-base homeostasisAllosteric regulationPlasma membraneRegulation of intracellularStimulus-response couplingIntracellular protonsPathophysiological processesPhysiological roleTransport systemTransmembrane exchangeCell growthAcid-base homeostasisRegulationSodium-hydrogen exchangeKinetic propertiesSuch diverse conditionsMetabolic responsePathophysiological roleDiverse conditionsCellsCell volumeRoleHomeostasisIntracellular
1980
Mechanism of increased potassium secretion in potassium loading and sodium deprivation
Hayslett J, Myketey N, Binder H, Aronson P. Mechanism of increased potassium secretion in potassium loading and sodium deprivation. American Journal Of Physiology 1980, 239: f378-f382. PMID: 6252786, DOI: 10.1152/ajprenal.1980.239.4.f378.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl CyclasesAnimalsBinding SitesColonDiet, Sodium-RestrictedIntestinal MucosaMaleOuabainPotassiumRatsSodiumSodium-Potassium-Exchanging ATPaseConceptsPlasma membrane-rich fractionMembrane-rich fractionBasolateral cell membraneCell membraneBasolateral membraneColonic cellsEnzyme activityK adaptationNa-K-ATPase activityMembraneColonic mucosal cellsEnzymeCellsMarker enzymesSpecific bindingOuabain-binding sitesAdenylate cyclaseSodium-deprived animalsAnimalsProteinK pumpActivityMucosal cellsATPSites