2006
Role of SLC26‐Mediated Cl−/Base Exchange in Proximal Tubule NaCl Transport
Aronson PS. Role of SLC26‐Mediated Cl−/Base Exchange in Proximal Tubule NaCl Transport. Novartis Foundation Symposia 2006, 273: 148-163. PMID: 17120766, DOI: 10.1002/0470029579.ch10.Commentaries, Editorials and Letters
2004
Renal and intestinal transport defects in Slc26a6-null mice
Wang Z, Wang T, Petrovic S, Tuo B, Riederer B, Barone S, Lorenz JN, Seidler U, Aronson PS, Soleimani M. Renal and intestinal transport defects in Slc26a6-null mice. American Journal Of Physiology - Cell Physiology 2004, 288: c957-c965. PMID: 15574486, DOI: 10.1152/ajpcell.00505.2004.Peer-Reviewed Original ResearchConceptsWild-type miceProximal tubulesSlc26a6-null miceHCO3- secretionKidney proximal tubulesApical membrane ClNull miceBaseline rateNormal blood pressureCl-/formate exchangeBlood pressureKidney functionElectrolyte profileMucosal tissuesIntestinal physiologyUssing chambersSmall intestineMiceFluid absorptionNaCl absorptionStatistical significanceCl-/HCO3NaCl transportDuodenumTubules
2002
Formate-stimulated NaCl absorption in the proximal tubule is independent of the pendrin protein
Karniski LP, Wang T, Everett LA, Green ED, Giebisch G, Aronson PS. Formate-stimulated NaCl absorption in the proximal tubule is independent of the pendrin protein. American Journal Of Physiology. Renal Physiology 2002, 283: f952-f956. PMID: 12372770, DOI: 10.1152/ajprenal.00182.2002.Peer-Reviewed Original ResearchConceptsProximal tubulesChloride/formate exchangeNaCl reabsorptionChloride reabsorptionElectroneutral NaCl reabsorptionNaCl absorptionRole of pendrinFormate exchangePds-knockout mouseRecycling of formatePendrin proteinReabsorptionMicePendrinBrush border membrane vesiclesTubulesPresent studyChloride transportApical membraneFunctional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy
Knauf F, Rogina B, Jiang Z, Aronson PS, Helfand SL. Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 14315-14319. PMID: 12391301, PMCID: PMC137881, DOI: 10.1073/pnas.222531899.Peer-Reviewed Original ResearchConceptsPlasma membraneLife-extending mutationsNew longevity genesIntermediary metabolismAdult fat bodyIndy expressionCitric acid cycleLife-extending effectsMetabolite transportersVariety of speciesLongevity genesFunctional characterizationLife spanMidgut cellsFat bodyAcid cycleFunctional studiesXenopus oocytesTransport functionIndyBasolateral regionSodium-independent mechanismProminent expressionAverage life spanTransportersUse of transgenic animals to study renal acid-base transport.
Wang T, Giebisch G, Aronson PS. Use of transgenic animals to study renal acid-base transport. Journal Of Nephrology 2002, 15 Suppl 5: s151-60. PMID: 12027214.Commentaries, Editorials and LettersConceptsAcid-base transportSpecific transporter isoformsSuch knockout miceRenal acid-base transportRenal acid-base homeostasisTransgenic miceTransporter isoformsPump subunitsTransgenic animalsKnockout micePhysiological roleATPase isoformsTransport deficiencyMolecular levelAcid-base homeostasisIsoformsAdaptive mechanismsCarbonic anhydraseCompensatory-adaptive mechanismsUseful experimental modelTransportersRegulatory mediatorsNHE isoformsNitric oxideExperimental model
2001
Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron
Wang T, Hropot M, Aronson P, Giebisch G. Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron. American Journal Of Physiology. Renal Physiology 2001, 281: f1117-f1122. PMID: 11704563, DOI: 10.1152/ajprenal.2001.281.6.f1117.Peer-Reviewed Original ResearchConceptsLoop of HenleHOE 694Proximal tubulesAddition of ethylisopropylamilorideDistal convoluted tubuleBicarbonate reabsorptionConvoluted tubulesSitu microperfusionRat kidneySignificant inhibitionNHE isoformsHenlePredominant isoformTubulesNHE3Functional roleInhibitionNHE2Apical membraneIsoformsApical isoformKidneyMicroperfusionEthylisopropylamilorideNephron
1997
Mechanisms of chloride transport in the proximal tubule
Aronson PS, Giebisch G. Mechanisms of chloride transport in the proximal tubule. American Journal Of Physiology 1997, 273: f179-f192. PMID: 9277578, DOI: 10.1152/ajprenal.1997.273.2.f179.Commentaries, Editorials and Letters
1996
Mechanism of H(+)-coupled formate transport in rabbit renal microvillus membranes
Saleh AM, Rudnick H, Aronson PS. Mechanism of H(+)-coupled formate transport in rabbit renal microvillus membranes. American Journal Of Physiology 1996, 271: f401-f407. PMID: 8770172, DOI: 10.1152/ajprenal.1996.271.2.f401.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsBiological TransportFormatesHydrogenHydrogen-Ion ConcentrationKidneyMaleMicrovilliRabbitsConceptsNonionic diffusionMechanisms of stimulation of proximal tubule chloride transport by formate and oxalate
Wang T, Egbert AL, Abbiati T, Aronson PS, Giebisch G. Mechanisms of stimulation of proximal tubule chloride transport by formate and oxalate. American Journal Of Physiology 1996, 271: f446-f450. PMID: 8770178, DOI: 10.1152/ajprenal.1996.271.2.f446.Peer-Reviewed Original ResearchPathways for Oxalate Transport in Rabbit Renal Microvillus Membrane Vesicles*
Kuo S, Aronson P. Pathways for Oxalate Transport in Rabbit Renal Microvillus Membrane Vesicles*. Journal Of Biological Chemistry 1996, 271: 15491-15497. PMID: 8663096, DOI: 10.1074/jbc.271.26.15491.Peer-Reviewed Original Research
1995
Stimulation of chloride transport by cAMP in rat proximal tubules
Wang T, Segal AS, Giebisch G, Aronson PS. Stimulation of chloride transport by cAMP in rat proximal tubules. American Journal Of Physiology 1995, 268: f204-f210. PMID: 7864157, DOI: 10.1152/ajprenal.1995.268.2.f204.Peer-Reviewed Original ResearchConceptsRat proximal tubuleProximal tubulesDibutyryl cAMPCapillary perfusateLate proximal tubuleProximal tubule cellsCl- channel blockerCl- channelsTranscellular Cl absorptionAddition of forskolinLuminal DIDSSensitive Cl- channelBasolateral membraneLuminal perfusateTubule cellsCAMP productionFluid absorptionCl absorptionMM ClPerfusateJclRecent evidenceLuminal membraneTubulesEffect of cAMP
1994
Effects of inhibitors on anion exchangers in rabbit renal brush border membrane vesicles.
McConnell KR, Aronson PS. Effects of inhibitors on anion exchangers in rabbit renal brush border membrane vesicles. Journal Of Biological Chemistry 1994, 269: 21489-21494. PMID: 8063783, DOI: 10.1016/s0021-9258(17)31830-6.Peer-Reviewed Original ResearchWeak acid permeability of a villous membrane: Formic acid transport across rat proximal tubule
Krahn T, Aronson P, Weinstein A. Weak acid permeability of a villous membrane: Formic acid transport across rat proximal tubule. Bulletin Of Mathematical Biology 1994, 56: 459-490. PMID: 8087078, DOI: 10.1007/bf02460467.Peer-Reviewed Original Research
1993
Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ER
Biemesderfer D, Dekan G, Aronson PS, Farquhar MG. Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ER. American Journal Of Physiology 1993, 264: f1011-f1020. PMID: 8322889, DOI: 10.1152/ajprenal.1993.264.6.f1011.Peer-Reviewed Original ResearchEffects of formate and oxalate on chloride absorption in rat distal tubule
Wang T, Agulian SK, Giebisch G, Aronson PS. Effects of formate and oxalate on chloride absorption in rat distal tubule. American Journal Of Physiology 1993, 264: f730-f736. PMID: 8386473, DOI: 10.1152/ajprenal.1993.264.4.f730.Peer-Reviewed Original Research
1991
Cation specificity and modes of the Na+:CO3(2-):HCO3- cotransporter in renal basolateral membrane vesicles
Soleimani M, Lesoine GA, Bergman JA, Aronson PS. Cation specificity and modes of the Na+:CO3(2-):HCO3- cotransporter in renal basolateral membrane vesicles. Journal Of Biological Chemistry 1991, 266: 8706-8710. PMID: 2026588, DOI: 10.1016/s0021-9258(18)31503-5.Peer-Reviewed Original ResearchBasolateral transport pathways for K+ and Cl- in rabbit proximal tubule: effects on cell volume
Schild L, Aronson PS, Giebisch G. Basolateral transport pathways for K+ and Cl- in rabbit proximal tubule: effects on cell volume. American Journal Of Physiology 1991, 260: f101-f109. PMID: 1992774, DOI: 10.1152/ajprenal.1991.260.1.f101.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportCell Membrane PermeabilityChloridesKidney Tubules, ProximalPotassiumPotassium ChannelsRabbits
1989
Ionic mechanism of Na+-HCO3 − cotransport in rabbit renal basolateral membrane vesicles*
Soleimani M, Aronson PS. Ionic mechanism of Na+-HCO3 − cotransport in rabbit renal basolateral membrane vesicles*. Journal Of Biological Chemistry 1989, 264: 18302-18308. PMID: 2509453, DOI: 10.1016/s0021-9258(18)51463-0.Peer-Reviewed Original Research4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsAnionsBicarbonatesBinding, CompetitiveBiological TransportCarbon DioxideCarrier ProteinsCell MembraneHydrogen-Ion ConcentrationKidneyLithiumMaleRabbitsSodiumSodium-Bicarbonate SymportersStilbenesSulfitesEffects of acetazolamide on Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex.
Soleimani M, Aronson PS. Effects of acetazolamide on Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex. Journal Of Clinical Investigation 1989, 83: 945-951. PMID: 2921327, PMCID: PMC303770, DOI: 10.1172/jci113980.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAcetatesAcetazolamideAmmoniaAnimalsBicarbonatesBiological TransportCarrier ProteinsCell MembraneHydrogen-Ion ConcentrationKidney CortexMaleRabbitsSodiumSodium-Bicarbonate Symporters
1988
Oxalate transport via the sulfate/HCO3 exchanger in rabbit renal basolateral membrane vesicles.
Kuo SM, Aronson PS. Oxalate transport via the sulfate/HCO3 exchanger in rabbit renal basolateral membrane vesicles. Journal Of Biological Chemistry 1988, 263: 9710-9717. PMID: 3384817, DOI: 10.1016/s0021-9258(19)81576-4.Peer-Reviewed Original Research4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsAnion Transport ProteinsAntiportersBicarbonatesBiological TransportCarrier ProteinsCell MembraneChloridesElectrochemistryHydrogen-Ion ConcentrationKidney CortexKineticsLactatesLactic AcidMaleMembrane PotentialsOxalatesOxalic AcidPotassiumRabbitsSulfate TransportersSulfatesValinomycin