The fermentation product 2,3-butanediol alters P. aeruginosa clearance, cytokine response and the lung microbiome
Nguyen M, Sharma A, Wu W, Gomi R, Sung B, Hospodsky D, Angenent LT, Worgall S. The fermentation product 2,3-butanediol alters P. aeruginosa clearance, cytokine response and the lung microbiome. The ISME Journal: Multidisciplinary Journal Of Microbial Ecology 2016, 10: 2978-2983. PMID: 27177192, PMCID: PMC5148197, DOI: 10.1038/ismej.2016.76.Peer-Reviewed Original ResearchConceptsEnvironmental microbesFermentation productsP. aeruginosa persistenceP. aeruginosa virulenceRespiratory tractLung microbiotaBacterial fermentation productsLung microbiomeP. aeruginosa respiratory tract infectionsP. aeruginosaP. aeruginosa clearanceRespiratory tract infectionsBiofilm formationMurine respiratory tractIL-6 responseDisease susceptibilityVirulenceMicrobiomeMicrobesColonizationTract infectionsAirway microbiomeCytokine responsesInflammatory responseMicrobiota diversity