2022
Within-host evolution of a gut pathobiont facilitates liver translocation
Yang Y, Nguyen M, Khetrapal V, Sonnert ND, Martin AL, Chen H, Kriegel MA, Palm NW. Within-host evolution of a gut pathobiont facilitates liver translocation. Nature 2022, 607: 563-570. PMID: 35831502, PMCID: PMC9308686, DOI: 10.1038/s41586-022-04949-x.Peer-Reviewed Original ResearchConceptsHost evolutionGene expression programsCell wall structureNon-synonymous mutationsComparative genomicsIndependent lineagesExperimental evolutionExpression programsDivergent evolutionRegulatory genesBacterial behaviorCritical regulatorBacterial translocationGut commensalsTranslocationE. gallinarumMesenteric lymph nodesInitiation of inflammationImmune evasionWall structureEvade DetectionMucosal nicheLactobacillus reuteriCommensalGut microbiota
2016
The fermentation product 2,3-butanediol alters P. aeruginosa clearance, cytokine response and the lung microbiome
Nguyen M, Sharma A, Wu W, Gomi R, Sung B, Hospodsky D, Angenent LT, Worgall S. The fermentation product 2,3-butanediol alters P. aeruginosa clearance, cytokine response and the lung microbiome. The ISME Journal: Multidisciplinary Journal Of Microbial Ecology 2016, 10: 2978-2983. PMID: 27177192, PMCID: PMC5148197, DOI: 10.1038/ismej.2016.76.Peer-Reviewed Original ResearchConceptsEnvironmental microbesFermentation productsP. aeruginosa persistenceP. aeruginosa virulenceRespiratory tractLung microbiotaBacterial fermentation productsLung microbiomeP. aeruginosa respiratory tract infectionsP. aeruginosaP. aeruginosa clearanceRespiratory tract infectionsBiofilm formationMurine respiratory tractIL-6 responseDisease susceptibilityVirulenceMicrobiomeMicrobesColonizationTract infectionsAirway microbiomeCytokine responsesInflammatory responseMicrobiota diversity