2020
Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains
Hao Z, Li J, Li B, Alder KD, Cahill SV, Munger AM, Lee I, Kwon H, Back J, Xu S, Kang M, Lee FY. Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains. Journal Of Bone And Mineral Research 2020, 36: 186-198. PMID: 32866293, PMCID: PMC9057220, DOI: 10.1002/jbmr.4175.Peer-Reviewed Original ResearchConceptsCigarette smoke exposureCigarette smokingFracture healingSmoke exposureMurine modelMolecular alterationsBALB/cJ miceBiomechanical testingPro-inflammatory mediatorsCytokine/chemokine analysisImpaired fracture healingMultiplex cytokine/chemokine analysisInitial inflammatory responseFracture healing capacityBALB/cJProgenitor cell activitySmoking miceTransverse femoral osteotomyFemoral osteotomyImmune cellsChemokine analysisInflammatory responseFracture hematomaHigh riskMurine strains
2003
Lung Matrix Metalloproteinase-9 Correlates with Cigarette Smoking and Obstruction of Airflow
Kang M, Oh Y, Lee J, Kim D, Park M, Lee M, Hyun I, Han S, Shim Y, Jung K. Lung Matrix Metalloproteinase-9 Correlates with Cigarette Smoking and Obstruction of Airflow. Journal Of Korean Medical Science 2003, 18: 821-827. PMID: 14676438, PMCID: PMC3055149, DOI: 10.3346/jkms.2003.18.6.821.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseMMP-9 concentrationsCigarette smokingMMP-9Matrix metalloproteinasesTIMP-1Lung parenchymaCharacteristics of COPDPathogenesis of COPDObstructive pulmonary diseaseMatrix metalloproteinase-9 correlatesImportant risk factorMMP-9 expressionObstruction of airflowHuman lung parenchymaFEV1 valuesPulmonary diseaseRisk factorsMMP expressionSmokingTissue inhibitorObstructionGelatinolytic bandsEnzyme immunoassayZymographic analysis