2003
Lung Matrix Metalloproteinase-9 Correlates with Cigarette Smoking and Obstruction of Airflow
Kang M, Oh Y, Lee J, Kim D, Park M, Lee M, Hyun I, Han S, Shim Y, Jung K. Lung Matrix Metalloproteinase-9 Correlates with Cigarette Smoking and Obstruction of Airflow. Journal Of Korean Medical Science 2003, 18: 821-827. PMID: 14676438, PMCID: PMC3055149, DOI: 10.3346/jkms.2003.18.6.821.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseMMP-9 concentrationsCigarette smokingMMP-9Matrix metalloproteinasesTIMP-1Lung parenchymaCharacteristics of COPDPathogenesis of COPDObstructive pulmonary diseaseMatrix metalloproteinase-9 correlatesImportant risk factorMMP-9 expressionObstruction of airflowHuman lung parenchymaFEV1 valuesPulmonary diseaseRisk factorsMMP expressionSmokingTissue inhibitorObstructionGelatinolytic bandsEnzyme immunoassayZymographic analysis
2001
The Increased Expression of Gelatinolytic Proteases Due to Gigarette Smoking Exposure in the Lung of Guinea Pig
Kang M, Lee J, Yoo C, Lee G, Chung H, Seo J, Kim Y, Han S, Shim Y. The Increased Expression of Gelatinolytic Proteases Due to Gigarette Smoking Exposure in the Lung of Guinea Pig. Tuberculosis And Respiratory Diseases 2001, 50: 426-436. DOI: 10.4046/trd.2001.50.4.426.Peer-Reviewed Original ResearchPathogenesis of COPDInflammatory cellular infiltrationIntraalveolar cellsCS exposureGuinea pigsCellular infiltrationLung parenchymeHistologic changesAlveolar wallsGelatinolytic enzymesAlveolar inflammatory cellsBAL fluid cellsDuration of CSDays/weekHours/daySmoking exposureBAL fluidInflammatory cellsLung parenchymaWeek groupMMP expressionGelatin zymographyControl groupAdult populationDestructive changes