2024
Intravascular Imaging–Guided Versus Angiography‐Guided Percutaneous Coronary Intervention: A Systematic Review and Meta‐Analysis of Randomized Trials
Sreenivasan J, Reddy R, Jamil Y, Malik A, Chamie D, Howard J, Nanna M, Mintz G, Maehara A, Ali Z, Moses J, Chen S, Chieffo A, Colombo A, Leon M, Lansky A, Ahmad Y. Intravascular Imaging–Guided Versus Angiography‐Guided Percutaneous Coronary Intervention: A Systematic Review and Meta‐Analysis of Randomized Trials. Journal Of The American Heart Association 2024, 13: e031111. PMID: 38214263, PMCID: PMC10926835, DOI: 10.1161/jaha.123.031111.Peer-Reviewed Original ResearchConceptsAdverse cardiac eventsPercutaneous coronary interventionAngiography-guided percutaneous coronary interventionTarget vessel revascularizationTarget-lesion revascularizationCardiac eventsCardiac deathImaging-guided percutaneous coronary interventionWeighted mean follow-up durationMeta-analysisPrimary outcomeMean follow-up durationStent thrombosisMeta-analysis of randomized trialsStudy-level meta-analysisComplex lesion subsetsIntravascular imagingAll-cause deathRandom-effects meta-analysisStandard of careIntention-to-treat principleUpdates of clinical guidelinesMixed-effects meta-regressionComplex percutaneous coronary interventionIntravascular imaging-guided percutaneous coronary intervention
2023
Comparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression
Park D, An S, Jolly N, Attanasio S, Yadav N, Gutierrez J, Nanna M, Rao S, Vij A. Comparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression. Catheterization And Cardiovascular Interventions 2023, 102: 440-450. PMID: 37483068, PMCID: PMC10908343, DOI: 10.1002/ccd.30784.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsPercutaneous coronary interventionOptical coherence tomographyCoronary angiographyIntravascular ultrasoundCoronary interventionCardiac deathClinical outcomesClinical efficacyConventional angiography-guided PCIAngiography-guided percutaneous coronary interventionCoherence tomographyUse of IVUSSuperiority of OCTAdverse cardiovascular eventsRandomized clinical trialsConventional coronary angiographyImaging modalitiesComparative clinical efficacyBest imaging modalityIntracoronary imaging modalityLesion revascularizationPCI guidanceCardiovascular eventsCause mortalityClinical and cost implications of deferred testing in low-risk patients with stable chest pain: a simulation using the PROMISE trial
Nanna M, Yow E, Vemulapalli S, Mark D, Kelsey M, Patel M, Al-Khalidi H, Rogers C, Udelson J, Douglas P. Clinical and cost implications of deferred testing in low-risk patients with stable chest pain: a simulation using the PROMISE trial. American Heart Journal 2023, 261: 124-126. PMID: 36828202, PMCID: PMC10903188, DOI: 10.1016/j.ahj.2023.02.010.Peer-Reviewed Original Research
2022
Are risk factors necessary for pretest probability assessment of coronary artery disease? A patient similarity network analysis of the PROMISE trial
Kolossváry M, Mayrhofer T, Ferencik M, Karády J, Pagidipati NJ, Shah SH, Nanna MG, Foldyna B, Douglas PS, Hoffmann U, Lu MT. Are risk factors necessary for pretest probability assessment of coronary artery disease? A patient similarity network analysis of the PROMISE trial. Journal Of Cardiovascular Computed Tomography 2022, 16: 397-403. PMID: 35393245, PMCID: PMC9452442, DOI: 10.1016/j.jcct.2022.03.006.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseCoronary CT angiographyCalcium scoreRisk factorsLuminal narrowingPTP scoreArtery diseasePatient characteristicsPROMISE trialStable chest pain patientsObstructive coronary artery diseasePretest probability assessmentChest pain patientsSimilar risk profilesCT angiographyImaging markerRisk profileDiagnostic accuracyCAD predictionSex groupsProbability calculatorScoresSubanalysesDiseaseGroup individuals
2021
The prospective randomized trial of the optimal evaluation of cardiac symptoms and revascularization: Rationale and design of the PRECISE trial
Nanna MG, Vemulapalli S, Fordyce CB, Mark DB, Patel MR, Al-Khalidi HR, Kelsey M, Martinez B, Yow E, Mullen S, Stone GW, Ben-Yehuda O, Udelson JE, Rogers C, Douglas PS. The prospective randomized trial of the optimal evaluation of cardiac symptoms and revascularization: Rationale and design of the PRECISE trial. American Heart Journal 2021, 245: 136-148. PMID: 34953768, PMCID: PMC8979644, DOI: 10.1016/j.ahj.2021.12.004.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseStable chest painChest painDiagnostic strategiesUsual careCardiac symptomsMajor adverse cardiac eventsNon-acute chest painObstructive coronary artery diseaseInitial diagnostic strategyInvasive cardiac catheterizationUse of CCTAUsual care strategyAdverse cardiac eventsProspective randomized trialsClinical care teamFractional flow reserveQuality of lifeHealth care costsOptimal evaluationPrimary endpointRevascularization TrialSecondary endpointsCardiac eventsArtery diseaseRise of the Machines: Where Virtual Processing Meets Percutaneous Coronary Intervention
Nanna MG, Jones WS. Rise of the Machines: Where Virtual Processing Meets Percutaneous Coronary Intervention. Canadian Journal Of Cardiology 2021, 37: 1504-1506. PMID: 34371117, DOI: 10.1016/j.cjca.2021.07.010.Peer-Reviewed Original ResearchEstimating the real-world performance of the PROMISE minimal-risk tool
Nanna MG, Wang TY, Chiswell K, Sun JL, Vemulapalli S, Hoffmann U, Patel MR, Udelson JE, Fordyce CB, Douglas PS. Estimating the real-world performance of the PROMISE minimal-risk tool. American Heart Journal 2021, 239: 100-109. PMID: 34077743, DOI: 10.1016/j.ahj.2021.05.016.Peer-Reviewed Original ResearchMeSH KeywordsAngina, StableComputed Tomography AngiographyCoronary AngiographyCoronary StenosisCoronary VesselsFemaleHeart Disease Risk FactorsHumansMaleMedical OveruseMiddle AgedMyocardial InfarctionMyocardial RevascularizationOutcome and Process Assessment, Health CarePrognosisRisk AssessmentUnited StatesConceptsObstructive coronary artery diseaseNon-low risk patientsLow-risk patientsCoronary artery diseaseStable chest painRisk patientsCardiac catheterizationArtery diseaseChest painMyocardial infarctionLower riskProspective Multicenter Imaging StudyStable chest pain patientsCardiovascular adverse outcomesMI-free survivalChest pain patientsObstructive coronary diseaseElective cardiac catheterizationLikelihood of freedomLogistic regression modelingOutcomes of interestPositive predictive valueAlternative cut pointsIndex angiographyIndex catheterizationThe incremental value of angiographic features for predicting recurrent cardiovascular events: Insights from the Duke Databank for Cardiovascular Disease
Nanna MG, Peterson ED, Chiswell K, Overton RA, Nelson AJ, Kong DF, Navar AM. The incremental value of angiographic features for predicting recurrent cardiovascular events: Insights from the Duke Databank for Cardiovascular Disease. Atherosclerosis 2021, 321: 1-7. PMID: 33582446, PMCID: PMC8221430, DOI: 10.1016/j.atherosclerosis.2021.02.004.Peer-Reviewed Original ResearchConceptsSecondary risk predictionAngiographic featuresCardiovascular diseaseCardiovascular eventsClinical characteristicsDuke DatabankMultivariable modelIncremental valueRisk predictionAtherosclerotic cardiovascular disease eventsSignificant coronary artery diseaseBaseline clinical factorsDuke CAD indexRecurrent cardiovascular eventsCardiovascular disease eventsSame health systemCoronary artery diseasePrimary care physiciansCardiac catheterization patientsCoronary angiographic featuresRecurrent eventsRisk prediction modelAngiographic variablesInitial revascularizationAngiographic predictors
2020
Age-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease
Lowenstern A, Alexander KP, Hill CL, Alhanti B, Pellikka PA, Nanna MG, Mehta RH, Cooper LS, Bullock-Palmer RP, Hoffmann U, Douglas PS. Age-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease. JAMA Cardiology 2020, 5: 193-201. PMID: 31738382, PMCID: PMC6865842, DOI: 10.1001/jamacardio.2019.4973.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseOlder patientsMyocardial infarctionCV deathNoninvasive testsArtery diseaseNoninvasive evaluationElevated coronary artery calcium scoresDeath/myocardial infarctionPositive noninvasive test resultsPossible coronary artery diseaseProspective Multicenter Imaging StudyCoronary artery calcium scoreNonwhite race/ethnicityComparative effectiveness designArtery calcium scoreCoronary artery calciumMinority of patientsCause of morbidityNoninvasive test resultsFunctional test resultsAge-specific approachesBest noninvasive testPositive test resultsOlder age groups