2024
1817MO Effect of a weight loss intervention (WLI) on exercise behaviors in women with breast cancer: Results from the breast cancer weight loss (BWEL) trial
Ligibel J, Ballman K, mccall L, Goodwin P, Weiss A, Crane T, Irwin M, Thomson C, Hahn O, Spears P, Hershman D, Paskett E, Hopkins J, Bernstein V, Stearns V, White J, Wadden T, Winer E, Carey L, Partridge A. 1817MO Effect of a weight loss intervention (WLI) on exercise behaviors in women with breast cancer: Results from the breast cancer weight loss (BWEL) trial. Annals Of Oncology 2024, 35: s1078. DOI: 10.1016/j.annonc.2024.08.1913.Peer-Reviewed Original Research
2023
Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer
Cartmel B, Li F, Zhou Y, Gottlieb L, Lu L, Mszar R, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Risch H, Irwin M. Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer. Cancer Medicine 2023, 12: 15492-15503. PMID: 37269192, PMCID: PMC10417064, DOI: 10.1002/cam4.6187.Peer-Reviewed Original ResearchConceptsExercise interventionOvarian cancerTrial of exerciseExercise-induced changesMin/weekGroup differencesSubset of participantsCause mortalityExercise groupOverall survivalStudy armsCA 125Randomized trialsBlood biomarkersBlood drawBreast cancerClinical significanceIGF-1Effect model analysisSecondary analysisBeneficial effectsCancerBiomarkersTrialsWomen
2022
Effect of exercise on body composition among women with ovarian cancer
Cao A, Cartmel B, Li FY, Gottlieb LT, Harrigan M, Ligibel JA, Gogoi R, Schwartz PE, Irwin ML, Ferrucci LM. Effect of exercise on body composition among women with ovarian cancer. Journal Of Cancer Survivorship 2022, 17: 1386-1396. PMID: 35377104, PMCID: PMC9530065, DOI: 10.1007/s11764-022-01207-x.Peer-Reviewed Original ResearchConceptsDual-energy X-ray absorptiometryOvarian cancer survivorsAerobic exercise interventionEffects of exerciseCancer survivorsOvarian cancerExercise interventionBody compositionSix-month aerobic exercise interventionBone mineral densityBetween-group differencesBody fat percentageLean body massX-ray absorptiometrySecondary outcomesStudy armsAerobic exerciseLifestyle StudyMineral densityHigh riskCancerSurvivorsFat percentageWomenResultsOn average
2021
The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention
Delahanty LM, Wadden TA, Goodwin PJ, Alfano CM, Thomson CA, Irwin ML, Neuhouser ML, Crane TE, Frank E, Spears PA, Gillis BP, Hershman DL, Paskett ED, Hopkins J, Bernstein V, Stearns V, White J, Hudis C, Winer EP, Carey L, Partridge AH, Ligibel JA. The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention. Obesity 2021, 30: 28-38. PMID: 34932888, PMCID: PMC9186690, DOI: 10.1002/oby.23287.Peer-Reviewed Original ResearchConceptsWeight loss interventionWeight loss trialLifestyle interventionHealth education materialsWeight lossLoss trialPhysical activityInvasive disease-free survivalDisease-free survivalBreast cancer patientsBreast cancer diagnosisCare of thousandsEducation materialsBaseline weightCancer outcomesCancer patientsHealth coachesCancer recurrenceBreast cancerCaloric restrictionStage IITrialsCancer diagnosisInterventionWomenExploring the impact of exercise and mind–body prehabilitation interventions on physical and psychological outcomes in women undergoing breast cancer surgery
Knoerl R, Giobbie-Hurder A, Sannes TS, Chagpar AB, Dillon D, Dominici LS, Frank ES, Golshan M, McTiernan A, Rhei E, Tolaney SM, Winer EP, Yung RL, Irwin ML, Ligibel JA. Exploring the impact of exercise and mind–body prehabilitation interventions on physical and psychological outcomes in women undergoing breast cancer surgery. Supportive Care In Cancer 2021, 30: 2027-2036. PMID: 34648061, DOI: 10.1007/s00520-021-06617-8.Peer-Reviewed Original ResearchConceptsCancer treatment-related symptomsPrehabilitation interventionsTreatment-related symptomsTime of enrollmentImpact of exerciseQuality of lifeBreast cancerGroup participantsPre-operative exerciseBreast cancer surgeryMind-body interventionsCognitive functioningOpportunity trialCancer surgeryOutcome measuresSecondary analysisOne monthSurgeryMeasures of qualityGroup comparisonsCancer diagnosisCancerWomenInterventionSignificant differences
2018
The Breast Cancer Weight Loss (BWEL) trial: Randomized phase III trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early-stage breast cancer (Alliance A011401).
Ligibel J, Barry W, Alfano C, Hershman D, Irwin M, Neuhouser M, Thomson C, Delahanty L, Frank E, Spears P, Paskett E, Hopkins J, Bernstein V, Stearns V, White J, Wadden T, Goodwin P, Carey L, Partridge A, Winer E. The Breast Cancer Weight Loss (BWEL) trial: Randomized phase III trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early-stage breast cancer (Alliance A011401). Journal Of Clinical Oncology 2018, 36: tps598-tps598. DOI: 10.1200/jco.2018.36.15_suppl.tps598.Peer-Reviewed Original Research
2016
Impact of a pre-operative exercise intervention on Ki-67 and metabolic markers in women with early breast cancer.
Ligibel J, Giobbie-Hurder A, Shockro L, Rhei E, Troyan S, Dominici L, Chagpar A, Frank E, McTiernan A, Yung R, Freedman R, Tolaney S, O'Connor K, Stecker K, Dillon D, Irwin M. Impact of a pre-operative exercise intervention on Ki-67 and metabolic markers in women with early breast cancer. Journal Of Clinical Oncology 2016, 34: 564-564. DOI: 10.1200/jco.2016.34.15_suppl.564.Peer-Reviewed Original Research
2010
Fasting C-Peptide Levels and Death Resulting From All Causes and Breast Cancer: The Health, Eating, Activity, and Lifestyle Study
Irwin ML, Duggan C, Wang CY, Smith AW, McTiernan A, Baumgartner RN, Baumgartner KB, Bernstein L, Ballard-Barbash R. Fasting C-Peptide Levels and Death Resulting From All Causes and Breast Cancer: The Health, Eating, Activity, and Lifestyle Study. Journal Of Clinical Oncology 2010, 29: 47-53. PMID: 21115859, PMCID: PMC3055859, DOI: 10.1200/jco.2010.28.4752.Peer-Reviewed Original ResearchConceptsC-peptide levelsRisk of deathType 2 diabetesBreast cancerHazard ratioLifestyle StudyC-peptideDietary-induced weight lossSerum C-peptideCox regression analysisBody mass indexRegional breast cancerBreast cancer diagnosisMass indexInsulin secretionTreatment strategiesObservational studyEstrogen receptorPhysical activityCancerWeight lossCancer diagnosisCertain subgroupsWomenDeathEnergy Balance, Cancer Prognosis, and Survivorship
Irwin M. Energy Balance, Cancer Prognosis, and Survivorship. Energy Balance And Cancer 2010, 219-232. DOI: 10.1007/978-1-4419-5515-9_8.Peer-Reviewed Original Research
2008
Influence of Pre- and Postdiagnosis Physical Activity on Mortality in Breast Cancer Survivors: The Health, Eating, Activity, and Lifestyle Study
Irwin ML, Smith AW, McTiernan A, Ballard-Barbash R, Cronin K, Gilliland FD, Baumgartner RN, Baumgartner KB, Bernstein L. Influence of Pre- and Postdiagnosis Physical Activity on Mortality in Breast Cancer Survivors: The Health, Eating, Activity, and Lifestyle Study. Journal Of Clinical Oncology 2008, 26: 3958-3964. PMID: 18711185, PMCID: PMC2654316, DOI: 10.1200/jco.2007.15.9822.Peer-Reviewed Original ResearchConceptsPhysical activityBreast cancerHazard ratioLifestyle StudyTotal deathsModerate-intensity physical activityMultivariable hazard ratiosPostdiagnosis physical activityProspective observational studyBreast cancer deathsBreast cancer survivorsMetabolic equivalent hoursRegional breast cancerPostdiagnosis changesPrimary outcomeCancer survivorsPrimary exposureCancer deathInactive womenObservational studyLower riskGreater riskDiagnosisInfluence of preWomen
2005
A Prospective Cohort Study Of Physical Activity In Relation To Disease-free Survival Of Breast Cancer In Women Diagnosed With Breast Cancer
Irwin M, McTiernan A, Baumgartner R, Baumgartner K, Bernstein L, Gilliland F, Ballard-Barbash R. A Prospective Cohort Study Of Physical Activity In Relation To Disease-free Survival Of Breast Cancer In Women Diagnosed With Breast Cancer. Medicine & Science In Sports & Exercise 2005, 37: s358. DOI: 10.1097/00005768-200505001-01878.Peer-Reviewed Original ResearchA Prospective Cohort Study Of Physical Activity In Relation To Disease-free Survival Of Breast Cancer In Women Diagnosed With Breast Cancer
Irwin M, McTiernan A, Baumgartner R, Baumgartner K, Bernstein L, Gilliland F, Ballard-Barbash R. A Prospective Cohort Study Of Physical Activity In Relation To Disease-free Survival Of Breast Cancer In Women Diagnosed With Breast Cancer. Medicine & Science In Sports & Exercise 2005, 37: s358. DOI: 10.1249/00005768-200505001-01878.Peer-Reviewed Original Research
2003
Effect of Exercise on Total and Intraabdominal Body Fat in Postmenopausal Women: A Randomized, Controlled Trial
Irwin M, Yasui Y, Ulrich C, Bowen D, Rudolph R, Schwartz R, Yukawa M, Aiello E, Potter J, McTiernan A. Effect of Exercise on Total and Intraabdominal Body Fat in Postmenopausal Women: A Randomized, Controlled Trial. Obstetrical & Gynecological Survey 2003, 58: 469-470. DOI: 10.1097/01.ogx.0000074098.18035.5e.Peer-Reviewed Original ResearchPhysical activity levels before and after a diagnosis of breast carcinoma
Irwin ML, Crumley D, McTiernan A, Bernstein L, Baumgartner R, Gilliland FD, Kriska A, Ballard‐Barbash R. Physical activity levels before and after a diagnosis of breast carcinoma. Cancer 2003, 97: 1746-1757. PMID: 12655532, PMCID: PMC3034406, DOI: 10.1002/cncr.11227.Peer-Reviewed Original ResearchConceptsBody mass indexPhysical activityBreast carcinomaIncident breast carcinomaPopulation-based studyRisk of recurrenceTotal physical activitySport physical activityPrediagnosis levelsAdjuvant treatmentPatient ageMass indexType of sportAdverse outcomesDisease stageTime patientsBaseline interviewBody weightPA levelsWeight gainPatientsDiagnosisCarcinomaWomenChemotherapy
2002
Exercise Effect on Body Weight in Postmenopausal Women: The Physical Activity for Total Health Study
Irwin M, McTiernan A. Exercise Effect on Body Weight in Postmenopausal Women: The Physical Activity for Total Health Study. Medical Science Symposia Series 2002, 17: 345-352. DOI: 10.1007/978-1-4615-1061-1_41.Peer-Reviewed Original ResearchTotal Health studyPrevalence of overweightAdult American populationObese 1Postmenopausal womenObesity comorbiditiesCardiovascular diseasePhysical activitySedentary lifestyleHealth StudyBody weightOlder personsCertain cancersOverweightObesityPrevalenceLevel 4American populationHypertensionComorbiditiesDiabetesStrokeCancerDiseaseWomen
2001
The association between physical activity, cardiorespiratory fitness, and lipoprotein(a) concentrations in a tri-ethnic sample of women: The Cross-Cultural Activity Participation Study
Drowatzky K, Durstine J, Irwin M, Moore C, Davis P, Hand G, Gonzalez M, Ainsworth B. The association between physical activity, cardiorespiratory fitness, and lipoprotein(a) concentrations in a tri-ethnic sample of women: The Cross-Cultural Activity Participation Study. Vascular Medicine 2001, 6: 15-21. PMID: 11358155, DOI: 10.1177/1358836x0100600104.Peer-Reviewed Original ResearchConceptsMaximal treadmill timeTreadmill timePhysical activityAfrican American womenCaucasian womenFasted blood samplesPhysical activity levelsCross-Cultural Activity Participation StudyCross-sectional studyPhysical activity recordsEthnic differencesPhysical activity variablesTri-ethnic populationCardiorespiratory fitnessExercise testSignificant ethnic differencesBlood samplesTri-ethnic sampleWomenDlActivity levelsAfrican AmericansActivity variablesCaucasiansNative Americans
1999
Moderate Physical Activity Patterns of Minority Women: The Cross-Cultural Activity Participation Study
Ainsworth B, Irwin M, Addy C, Whitt M, Stolarczyk L. Moderate Physical Activity Patterns of Minority Women: The Cross-Cultural Activity Participation Study. Journal Of Women's Health 1999, 8: 805-813. PMID: 10495261, DOI: 10.1089/152460999319129.Peer-Reviewed Original ResearchConceptsCross-Cultural Activity Participation StudyPhysical activity patternsRegular physical activityPhysical Activity SurveySports Medicine recommendationsThird of womenPhysical activity recordsMinutes/dayModerate-intensity activityProportion of womenModerate activityMedicine recommendationsAge 40Physical activityAmerican CollegeMost womenActivity patternsIntensity activityDisease controlPA recordsWomenSports activitiesMinority womenNative American womenActivity Survey