2023
The Transcriptional Landscape of Ph+B-ALL Is Orchestrated By Long-Range Enhancer-Promoter Interactions and the Coordinated Action of Phosphorylation-Dependent and Phosphorylation-Independent Transcription Factors
Ng H, Robinson M, Malysheva V, Deniz O, Crump N, Cosgun K, Helian K, Spivakov M, Müschen M, Feldhahn N. The Transcriptional Landscape of Ph+B-ALL Is Orchestrated By Long-Range Enhancer-Promoter Interactions and the Coordinated Action of Phosphorylation-Dependent and Phosphorylation-Independent Transcription Factors. Blood 2023, 142: 2779. DOI: 10.1182/blood-2023-173435.Peer-Reviewed Original ResearchTranscription factorsTranscriptional programsEnhancer signatureGene expressionChromatin interactionsTranscriptional changesTyrosine kinaseAdditional transcription factorsMotif enrichment analysisPromoter-enhancer interactionsCis-regulatory elementsEnhancer-promoter interactionsPromoter capture HiNon-promoter regionsUnique transcriptional programGene expression changesCoordinated actionMurine B cell precursorsOncogenic tyrosine kinasesEnhancer usageActive chromatinActive genesEnhancer landscapeTranscriptional landscapeActive enhancers
2016
Transcriptional Regulatory Landscape of TCF3-PBX1-Positive Leukemia and Novel Targeted Treatments
Teppo S, Mehtonen J, Eldfors S, Heckman C, Müschen M, Heinäniemi M, Lohi O. Transcriptional Regulatory Landscape of TCF3-PBX1-Positive Leukemia and Novel Targeted Treatments. Blood 2016, 128: 4077. DOI: 10.1182/blood.v128.22.4077.4077.Peer-Reviewed Original ResearchTranscriptional regulatory landscapeTranscription factorsRegulatory landscapeCell line modelsFusion proteinGenome-wide mapsGlobal nuclear runNovel long non-coding RNANetwork inference analysisDruggable targetsLong non-coding RNAsGene expression differencesNon-coding RNAsGene Expression OmnibusGRO-seq analysisTumor suppressor genePBX1 functionsNovel drug targetsNascent transcriptionTranscriptional landscapeEnhancer RNAsGenomic regionsGRO-seqNetwork inference algorithmsExpression differences