Analysis of Ikaros tumor suppressor function in BCR-ABL1+ pre-B ALL reveals conserved target genes and biological pathways
Schjerven H, Ayongaba E, McLaughlin J, Cheng D, Eggesbø L, Lindeman I, Park E, Witte O, Smale S, Frietze S, Muschen M. Analysis of Ikaros tumor suppressor function in BCR-ABL1+ pre-B ALL reveals conserved target genes and biological pathways. The Journal Of Immunology 2016, 196: 122.6-122.6. DOI: 10.4049/jimmunol.196.supp.122.6.Peer-Reviewed Original ResearchTumor suppressor functionTarget genesDevelopmental stage-specific expressionSuppressor functionB cell developmentStem cell signatureZinc fingerHematopoietic developmentIkaros DNAIkaros functionEarly hematopoietic progenitor cellsHematopoietic progenitor cellsRNA sequencingReceptor c-kitMultiple genesBiological functionsInducible expressionTumor suppressionTumor suppressorBiological pathwaysSpecific expressionAdhesion pathwayCritical regulatorIkarosGenes