2023
Optogenetic Control of Oncogenic Signaling in B-Cell Malignancies
Kume K, Lee J, Cheng Z, Robinson M, Leveille E, Cosgun K, Chan L, Feng Y, Arce D, Khanduja D, Toomre D, Müschen M. Optogenetic Control of Oncogenic Signaling in B-Cell Malignancies. Blood 2023, 142: 4138. DOI: 10.1182/blood-2023-190926.Peer-Reviewed Original ResearchB-cell malignanciesB-cell lymphomaMature B-cell lymphomasB cell deathB cellsB cell developmentGenetic deletionMantle cell lymphomaNF-kB signalingBCR signal inhibitorsB cell precursorsCell of originCell viabilityChronic active BCRB cell survivalB cell receptor signalsHodgkin's diseaseMultiple myelomaNormal B cell developmentPlasma cellsBtk tyrosine kinaseCell lymphomaBurkitt's lymphomaNF-kBSmall molecule inhibitors
2001
Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions
Küppers R, Bräuninger A, Müschen M, Distler V, Hansmann M, Rajewsky K. Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions. Blood 2001, 97: 818-821. PMID: 11157505, DOI: 10.1182/blood.v97.3.818.Peer-Reviewed Original ResearchConceptsHodgkin's diseaseReed-Sternberg cellsHRS cellsT-cell receptor beta rearrangementsCases of HDClassical Hodgkin's diseaseCoexpression of markersCell fusionNumerical chromosomal abnormalitiesUnusual immunophenotypeT cellsRare caseB cellsBeta rearrangementChromosomal abnormalitiesGermline configurationIgH allelesDifferent hematopoietic lineagesDiseaseHodgkinCell generationCellsTCRbeta allelesHematopoietic lineagesImmunoglobulin genes