Circadian Clock Protein CRY Controls B-Cell Intrinsic Tolerance
Cao Q, Zhao X, Gery S, Chen Z, Deng R, Sun H, Lin D, Zhao Z, Said J, Li Q, Muschen M, Evans R, Koeffler H. Circadian Clock Protein CRY Controls B-Cell Intrinsic Tolerance. Blood 2015, 126: 1029. DOI: 10.1182/blood.v126.23.1029.1029.Peer-Reviewed Original ResearchB cell toleranceDKO miceB cellsRheumatoid arthritisMultiple sclerosisWT miceCell toleranceSerum anti-nuclear antibodiesHigher serum IgG concentrationsMature recirculating B cellsPeripheral B cell toleranceAnti-nuclear antibodiesPre-B cell numbersWild-type miceSerum IgG concentrationB2 B cellsRecirculating B cellsAdaptive immune systemSplenic B cellsImmune toleranceSevere autoimmunitySjögren's syndromeAutoimmune disordersMassive infiltrationComplement 3