2014
Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response
Dhingra N, Shemer A, da Rosa J, Rozenblit M, Fuentes-Duculan J, Gittler JK, Finney R, Czarnowicki T, Zheng X, Xu H, Estrada YD, Cardinale I, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response. Journal Of Allergy And Clinical Immunology 2014, 134: 362-372. PMID: 24768652, DOI: 10.1016/j.jaci.2014.03.009.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisHuman allergic contact dermatitisTh1/Th17Different allergensHigher immune activationMurine contact hypersensitivityStrong Th2 biasContact hypersensitivity modelCommon occupational diseaseT cell activationTh22 polarizationCommon allergensContact hypersensitivityTh2 biasDermatitis skinImmune activationClinical reactionsHypersensitivity modelImmune polarizationIndividual allergensContact dermatitisImmune responseAllergen groupsInnate immunityOccupational diseases
2006
Evidence that estrogen directly and indirectly modulates C1 adrenergic bulbospinal neurons in the rostral ventrolateral medulla
Wang G, Drake C, Rozenblit M, Zhou P, Alves S, Herrick S, Hayashi S, Warrier S, Iadecola C, Milner T. Evidence that estrogen directly and indirectly modulates C1 adrenergic bulbospinal neurons in the rostral ventrolateral medulla. Brain Research 2006, 1094: 163-178. PMID: 16696957, DOI: 10.1016/j.brainres.2006.03.089.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PressureDendritesDose-Response Relationship, DrugEfferent PathwaysEpinephrineEstradiolEstradiol CongenersEstrogen AntagonistsEstrogen Receptor alphaEstrogen Receptor betaEstrogensFemaleHypertensionMedulla OblongataMembrane PotentialsPatch-Clamp TechniquesPostmenopausePresynaptic TerminalsRatsRats, Sprague-DawleySpinal CordSympathetic Nervous SystemTyrosine 3-MonooxygenaseConceptsBlood pressure controlERalpha-irERbeta-irBulbospinal neuronsSympathetic toneCurrent inhibitionPressure controlRostral ventrolateral medulla (RVLM) regionWhole-cell patch-clamp recordingsBulbospinal RVLM neuronsER antagonist ICI182780ERalpha-selective agonistEstrogen receptor immunoreactivityRostral ventrolateral medullaC1 adrenergic neuronsEffects of estrogenPatch-clamp recordingsERbeta-selective agonistsC1 neuronsRVLM neuronsReceptor immunoreactivityVentrolateral medullaBlood pressureAdrenergic neuronsEstrogen effects