A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer
Lazova R, LaBerge GS, Duvall E, Spoelstra N, Klump V, Sznol M, Cooper D, Spritz RA, Chang JT, Pawelek JM. A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer. PLOS ONE 2013, 8: e66731. PMID: 23840523, PMCID: PMC3694119, DOI: 10.1371/journal.pone.0066731.Peer-Reviewed Original ResearchMeSH KeywordsAgedBone Marrow CellsBone Marrow TransplantationBrain NeoplasmsCell FusionForensic GeneticsHumansLymphoma, B-CellMaleMelanomaTandem Repeat SequencesTissue DonorsConceptsBone marrow-derived cellsBone marrow transplantationMarrow-derived cellsTumor cellsAllogeneic bone marrow transplantationMelanoma brain metastasesGeneration of metastasesHuman cancersBlood lymphocyte DNATumor cell fusionsTumor initiating cellsBrain metastasesMarrow transplantationMetastatic melanomaSame patientAnimal studiesMetastasisLymphocyte DNATumorsCancer metastasisInitiating cellsTransplantationCancerPatient allelesLaser microdissection