2003
A Locus for Autosomal Dominant Mitral Valve Prolapse on Chromosome 11p15.4
Freed LA, Acierno JS, Dai D, Leyne M, Marshall JE, Nesta F, Levine RA, Slaugenhaupt SA. A Locus for Autosomal Dominant Mitral Valve Prolapse on Chromosome 11p15.4. American Journal Of Human Genetics 2003, 72: 1551-1559. PMID: 12707861, PMCID: PMC1180315, DOI: 10.1086/375452.Peer-Reviewed Original Research
1999
Prevalence and Clinical Outcome of Mitral-Valve Prolapse
Freed L, Levy D, Levine R, Larson M, Evans J, Fuller D, Lehman B, Benjamin E. Prevalence and Clinical Outcome of Mitral-Valve Prolapse. New England Journal Of Medicine 1999, 341: 1-7. PMID: 10387935, DOI: 10.1056/nejm199907013410101.Peer-Reviewed Original ResearchConceptsMitral valve prolapseTwo-dimensional echocardiographic criteriaClassic mitral valve prolapseStudy of patientsFramingham Heart StudyChest painFrequent complicationEchocardiographic criteriaElectrocardiographic abnormalitiesHeart failureUnadjusted prevalenceAdverse sequelaeClinical outcomesFifth examinationAtrial fibrillationCerebrovascular diseaseMitral regurgitationMitral leafletSex distributionGeneral populationHeart StudyProlapseOffspring CohortSuperior displacementPrevalencePrevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study)
Singh J, Evans J, Levy D, Larson M, Freed L, Fuller D, Lehman B, Benjamin E. Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study). The American Journal Of Cardiology 1999, 83: 897-902. PMID: 10190406, DOI: 10.1016/s0002-9149(98)01064-9.Peer-Reviewed Original ResearchConceptsBody mass indexColor Doppler echocardiographyClinical determinantsAortic regurgitationDoppler echocardiographyMass indexValvular regurgitationMultiple logistic regression analysisPopulation-based cohortPopulation-based estimatesLogistic regression analysisAnorectic drugsClinical variablesFramingham StudyHealthy menMale genderMild severityFemale genderMitralTricuspidGeneral populationRoutine examinationRegurgitationPrevalenceWomen
1997
Relation of Ultra-Low Frequency Heart Rate Variability to the Clinical Course of Chronic Aortic Regurgitation
Freed L, Stein K, Borer J, Hochreiter C, Supino P, Devereux R, Roman M, Kligfield P. Relation of Ultra-Low Frequency Heart Rate Variability to the Clinical Course of Chronic Aortic Regurgitation. The American Journal Of Cardiology 1997, 79: 1482-1487. PMID: 9185637, DOI: 10.1016/s0002-9149(97)00175-6.Peer-Reviewed Original ResearchConceptsFrequency heart rate variabilityHeart rate variabilityChronic aortic regurgitationEnd-point eventsAortic regurgitationSymptomatic patientsNew York Heart Association functional class IChronic severe aortic regurgitationLeft ventricular ejection fractionLV end-diastolic dimensionLV end-systolic dimensionMeasures of HRVRate variabilitySevere aortic regurgitationAortic valve replacementEnd-diastolic dimensionCongestive heart failureEnd-systolic dimensionFunctional class IVentricular ejection fractionSudden cardiac deathRegurgitant valvular diseaseClinical outcome eventsMean RR intervalAverage annual risk
1996
Rhythm annotation and interobserver reproducibility of measures of heart rate variability
Kroll D, Freed L, Stein K, Borer J, Kligfield P. Rhythm annotation and interobserver reproducibility of measures of heart rate variability. The American Journal Of Cardiology 1996, 78: 1055-1057. PMID: 8916491, DOI: 10.1016/s0002-9149(96)00537-1.Peer-Reviewed Original Research