2024
Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes
Olfson E, Farhat L, Liu W, Vitulano L, Zai G, Lima M, Parent J, Polanczyk G, Cappi C, Kennedy J, Fernandez T. Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes. Nature Communications 2024, 15: 5870. PMID: 38997333, PMCID: PMC11245598, DOI: 10.1038/s41467-024-50247-7.Peer-Reviewed Original ResearchConceptsDNA sequencesRisk genesHigh-confidence risk genesWhole-exome DNA sequencingSequencing of familiesIdentified de novoLysine demethylase 5BDNA variantsTrio cohortBiological pathwaysGenesSequencing cohortGenetic factorsChildhood neurodevelopmental disordersAttention-deficit/hyperactivity disorderSequenceVariantsADHD riskNeurodevelopmental disordersKDM5BDNAMutationsFamilyLysineDiscovery
2020
An integrated program of computer-presented and physical cognitive training exercises for children with attention-deficit/hyperactivity disorder
Wexler BE, Vitulano LA, Moore C, Katsovich L, Smith SD, Rush C, Grantz H, Dong J, Leckman JF. An integrated program of computer-presented and physical cognitive training exercises for children with attention-deficit/hyperactivity disorder. Psychological Medicine 2020, 51: 1524-1535. PMID: 32090720, DOI: 10.1017/s0033291720000288.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderExperimental medicine approachTAU groupMedicine approachHyperactivity disorderWeeks of treatmentCombined subtypeDiagnosis of ADHDClinical trial designHyperactive-impulsive subtypeAttention-deficit/hyperactivity disorderCross-over designDeficit hyperactivity disorderClinical improvementClinical symptomsRandomized crossCognitive dysfunctionCT groupPathophysiological heterogeneityCONSORT recommendationsTrial designResponse rateChange scoresSubtypesTargeted pathology
2016
A Randomized Controlled Trial of an Integrated Brain, Body, and Social Intervention for Children With ADHD
Smith SD, Vitulano LA, Katsovich L, Li S, Moore C, Li F, Grantz H, Zheng X, Eicher V, Guloksuz S, Zheng Y, Dong J, Sukhodolsky DG, Leckman JF. A Randomized Controlled Trial of an Integrated Brain, Body, and Social Intervention for Children With ADHD. Journal Of Attention Disorders 2016, 24: 780-794. PMID: 27178060, PMCID: PMC5107355, DOI: 10.1177/1087054716647490.Peer-Reviewed Original ResearchConceptsIntegrated brainComputerized cognitive remediation trainingCognitive remediation trainingSocial interventionsBehavior management strategiesRemediation trainingCognitive trainingMemory taskADHD symptomatologyADHD symptomsNeurocognitive testsTeacher ratingsBlinded clinician ratingGeneralized improvementADHDMultiple group comparisonsClinician ratingsMultiple domainsClinical functioningSignificant treatment effectOutcome measuresGroup comparisonsSecondary outcome measuresChildrenRatings
2014
Experiences of patients identifying with chronic Lyme disease in the healthcare system: a qualitative study
Ali A, Vitulano L, Lee R, Weiss TR, Colson ER. Experiences of patients identifying with chronic Lyme disease in the healthcare system: a qualitative study. BMC Primary Care 2014, 15: 79. PMID: 24885888, PMCID: PMC4012507, DOI: 10.1186/1471-2296-15-79.Peer-Reviewed Original ResearchConceptsChronic Lyme diseaseExperiences of patientsLyme diseaseHealth statusHealthcare providersHealthcare systemSubstantial clinical burdenBorrelia burgdorferi infectionHealth Belief ModelUnited States healthcare systemPersistent symptomsClinical burdenCAM therapiesDisease burdenDoctor-patient relationshipBurgdorferi infectionStates healthcare systemUnconventional therapiesCAM practitionersPatient experiencePatientsDiseaseClinical encountersHealthcare settingsBelief Model
2012
FAMILY ACCOMMODATION IN PEDIATRIC ANXIETY DISORDERS
Lebowitz ER, Woolston J, Bar‐Haim Y, Calvocoressi L, Dauser C, Warnick E, Scahill L, Chakir AR, Shechner T, Hermes H, Vitulano LA, King RA, Leckman JF. FAMILY ACCOMMODATION IN PEDIATRIC ANXIETY DISORDERS. Depression And Anxiety 2012, 30: 47-54. PMID: 22965863, PMCID: PMC3932435, DOI: 10.1002/da.21998.Peer-Reviewed Original ResearchConceptsChildhood anxiety disordersFamily Accommodation ScaleFamily accommodationAnxiety disordersMeasures of anxietyFamilies of childrenObsessive-compulsive disorderGood internal consistencyTwo-factor solutionAnxious childrenPediatric anxietyAccommodation ScaleSeparation anxietyGreater symptom severityAnxiety symptomsCompulsive disorderDivergent validityFamily routinesAnxietyDiagnostic InterviewPoor treatment outcomesInternal consistencySymptom severityMost parentsFactor analysis
2011
Coercive and Disruptive Behaviors in Pediatric Obsessive Compulsive Disorder: A Qualitative Analysis
Lebowitz ER, Vitulano LA, Omer H. Coercive and Disruptive Behaviors in Pediatric Obsessive Compulsive Disorder: A Qualitative Analysis. Psychiatry 2011, 74: 362-371. PMID: 22168296, DOI: 10.1521/psyc.2011.74.4.362.Peer-Reviewed Original ResearchConceptsFamily accommodationDisruptive behaviorCoercive behaviorPediatric obsessive-compulsive disorderObsessive-compulsive symptom dimensionsObsessive-compulsive childObsessive-compulsive disorderLevel of impairmentChild OCDCompulsive disorderSymptom dimensionsOCDInterview pointsClinical experience pointsSymptom severityTheory methodologyQualitative explorationAdolescentsChildrenEmergent themesSuch situationsParentsExperience pointsTreatment outcomesQualitative analysisEditorial Perspective: When OCD takes over…the family! Coercive and disruptive behaviours in paediatric obsessive compulsive disorder
Lebowitz ER, Vitulano LA, Mataix‐Cols D, Leckman JF. Editorial Perspective: When OCD takes over…the family! Coercive and disruptive behaviours in paediatric obsessive compulsive disorder. Journal Of Child Psychology And Psychiatry 2011, 52: 1249-1250. PMID: 22022883, DOI: 10.1111/j.1469-7610.2011.02480.x.Peer-Reviewed Original ResearchCoercive and disruptive behaviors in pediatric obsessive–compulsive disorder
Lebowitz ER, Omer H, Leckman JF. Coercive and disruptive behaviors in pediatric obsessive–compulsive disorder. Depression And Anxiety 2011, 28: 899-905. PMID: 21769998, PMCID: PMC4006629, DOI: 10.1002/da.20858.Peer-Reviewed Original Research
2010
A brief report: Yale Research Symposium on Complementary and Integrative Medicine.
Ali A, Vitulano LA. A brief report: Yale Research Symposium on Complementary and Integrative Medicine. The Yale Journal Of Biology And Medicine 2010, 83: 123-5. PMID: 20885898, PMCID: PMC2946124.Peer-Reviewed Original ResearchConceptsIntegrative medicineIntegrative medicine approachesLow back painAdjuvant chemotherapyBack painUnconventional therapiesCardiac arrhythmiasMedicine approachBrief reportNutritional influencesIntake effectsResearch SymposiumRigorous research methodsBone consumptionReportMedicineChemotherapyPainAcupunctureArrhythmiasTherapyCancer
2009
Effects of therapeutic suggestion in children undergoing general anesthesia: a randomized controlled trial
FORTIER MA, WEINBERG M, VITULANO LA, CHORNEY JM, MARTIN SR, KAIN ZN. Effects of therapeutic suggestion in children undergoing general anesthesia: a randomized controlled trial. Pediatric Anesthesia 2009, 20: 90-99. PMID: 20078802, DOI: 10.1111/j.1460-9592.2009.03225.x.Peer-Reviewed Original ResearchConceptsPostanesthesia care unitGeneral anesthesiaTherapeutic suggestionsNausea severityOtolaryngological surgeryPositive therapeutic suggestionsStandardized anesthetic procedureGroup differencesOperating room noisePostoperative nauseaCare unitNonpharmacological interventionsAnesthetic proceduresHigh incidenceHealthcare personnelPONVAnesthesiaGroup assignmentTrialsNauseaVomitingSurgeryChildrenSeverityInterventionRandomized Trial of Anger Control Training for Adolescents With Tourette's Syndrome and Disruptive Behavior
Sukhodolsky DG, Vitulano LA, Carroll DH, McGuire J, Leckman JF, Scahill L. Randomized Trial of Anger Control Training for Adolescents With Tourette's Syndrome and Disruptive Behavior. Journal Of The American Academy Of Child & Adolescent Psychiatry 2009, 48: 413-421. PMID: 19242384, DOI: 10.1097/chi.0b013e3181985050.Peer-Reviewed Original ResearchConceptsClinical Global Impressions-Improvement scaleTourette syndromeACT groupControl trainingTAU control groupPrimary outcome measureIndependent evaluatorsAnger control trainingRating Scale scoresDisruptive behaviorEnd point evaluationLarge trialsBehavior rating scale scoresRandomized subjectsTAU conditionOutcome measuresScale scoreControl groupSyndromeRating ScaleACT conditionBehavior Rating ScaleAdolescentsTrialsDisruptive Behavior Rating Scale
2003
Biopsychosocial issues and risk factors in the family when the child has a chronic illness
Lewis M, Vitulano LA. Biopsychosocial issues and risk factors in the family when the child has a chronic illness. Child And Adolescent Psychiatric Clinics Of North America 2003, 12: 389-399. PMID: 12910814, DOI: 10.1016/s1056-4993(03)00024-5.Peer-Reviewed Original ResearchConceptsChronic health conditionsChronic illnessHealth conditionsRisk factorsHealthy peersPsychiatric problemsBiopsychosocial issuesSocioeconomic statusBehavioral medicineChildrenIllnessSocial supportClinical demandFamily functioningAmerican childrenAdolescentsPsychological aspectsDiagnosisImpairmentPsychosocial issues for children and adolescents with chronic illness: self-esteem, school functioning and sports participation
Vitulano LA. Psychosocial issues for children and adolescents with chronic illness: self-esteem, school functioning and sports participation. Child And Adolescent Psychiatric Clinics Of North America 2003, 12: 585-592. PMID: 12910824, DOI: 10.1016/s1056-4993(03)00027-0.Peer-Reviewed Original Research
1998
OBSESSIVE-COMPULSIVE DISORDER AND SEPARATION ANXIETY
Martin A, Scahill L, Vitulano L, King R. OBSESSIVE-COMPULSIVE DISORDER AND SEPARATION ANXIETY. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 350-351. PMID: 9549953, DOI: 10.1097/00004583-199804000-00010.Peer-Reviewed Original ResearchSTIMULANT USE AND TRICHOTILLOMANIA
Martin A, Scahill L, Vitulano L, King R. STIMULANT USE AND TRICHOTILLOMANIA. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 349-350. PMID: 9549952, DOI: 10.1097/00004583-199804000-00009.Peer-Reviewed Original Research
1996
Behavioral Therapy in Children and Adolescents with Obsessive-Compulsive Disorder: A Pilot Study
Scahill L, Vitulano L, Brenner E, Lynch K, King R. Behavioral Therapy in Children and Adolescents with Obsessive-Compulsive Disorder: A Pilot Study. Journal Of Child And Adolescent Psychopharmacology 1996, 6: 191-202. PMID: 9231312, DOI: 10.1089/cap.1996.6.191.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleBehavioral treatmentBehavioral therapyRandomized clinical trialsTreatment of childrenChildren's Yale-Brown Obsessive Compulsive ScaleBehavioral therapy programObsessive Compulsive ScaleMedication treatmentPrimary diagnosisMonths posttreatmentClinical trialsTreatment endpointBooster sessionsDose reductionDose requirementsMedicationsUseful adjunctTherapeutic gainTreatment programTherapy programPilot studyCompulsive ScaleTreatment
1995
Childhood Trichotillomania: Clinical Phenomenology, Comorbidity, and Family Genetics
KING R, SCAHILL L, VITULANO L, SCHWAB-STONE M, TERCYAK K, RIDDLE M. Childhood Trichotillomania: Clinical Phenomenology, Comorbidity, and Family Genetics. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1451-1459. PMID: 8543512, DOI: 10.1097/00004583-199511000-00011.Peer-Reviewed Original Research
1992
Behavioral Treatment of Children and Adolescents with Trichotillomania
VITULANO L, KING R, SCAHILL L, COHEN D. Behavioral Treatment of Children and Adolescents with Trichotillomania. Journal Of The American Academy Of Child & Adolescent Psychiatry 1992, 31: 139-146. PMID: 1537765, DOI: 10.1097/00004583-199201000-00021.Peer-Reviewed Original ResearchConceptsStandard psychiatric careBehavioral treatment programTreatment modalitiesPsychiatric careBehavior disorderBehavioral treatmentTreatment programPilot findingsRelative safetyTrichotillomaniaBehavioral techniquesPotential effectivenessChildrenAdolescentsUseful rolePatientsPharmacologicalDisfigurementScalpCare
1990
Preventing out-of-home placement for high-risk children.
Vitulano L, Nagler S, Adnopoz J, Grigsby R. Preventing out-of-home placement for high-risk children. The Yale Journal Of Biology And Medicine 1990, 63: 285-91. PMID: 2275219, PMCID: PMC2589196.Peer-Reviewed Original Research
1986
TREATMENT RECOMMENDATION, IMPLEMENTATION, AND FOLLOW-UP IN CHILD ABUSE
Vitulano LA, Lewis M, Doran LD, Nordhaus B, Adnopoz J. TREATMENT RECOMMENDATION, IMPLEMENTATION, AND FOLLOW-UP IN CHILD ABUSE. American Journal Of Orthopsychiatry 1986, 56: 478-480. PMID: 3740230, DOI: 10.1111/j.1939-0025.1986.tb03479.x.Peer-Reviewed Original Research