Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation
Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. Journal Of Experimental Medicine 2010, 207: 2595-2607. PMID: 20975041, PMCID: PMC2989775, DOI: 10.1084/jem.20100786.Peer-Reviewed Original ResearchConceptsLung inflammationTh2-mediated lung inflammationSevere human asthmaAsthma-like phenotypeNonallergic miceHuman asthmaInflammation resultsKO miceLung tissueNogo expressionAirway epitheliumSmooth muscleReticulon 4BTransgenic miceLung epitheliumEpithelial reconstitutionMiceMarked reductionProtective genesEndogenous regulatorNogoInflammationLungPLUNCTransgenic expressionMicrobial And Inflammatory Signals Promote Airway Inflammation By Inhibiting The Epithelial Protein PLUNC
Britto C, Curran D, Liu Q, Cohn L. Microbial And Inflammatory Signals Promote Airway Inflammation By Inhibiting The Epithelial Protein PLUNC. 2010, a1389-a1389. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1389.Peer-Reviewed Original Research