2013
AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine
Tsai CT, Yang PM, Chern TR, Chuang SH, Lin JH, Klemm L, Müschen M, Chen CC. AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine. Oncotarget 2013, 5: 211-223. PMID: 24457556, PMCID: PMC3960202, DOI: 10.18632/oncotarget.1319.Peer-Reviewed Original ResearchConceptsActivation-induced cytidine deaminaseClass switch recombinationTumor suppressor geneHematopoietic cancer cellsAID expressionSomatic hypermutationNovel biological functionDNMT inhibitor 5Cancer cellsHost genesProteasomal degradationDNMT inhibitorsNovel functionBiological functionsInhibitor 5Suppressor geneSwitch recombinationImmunoglobulin genesCancer progressionCytidine deaminaseGenesDNMT1ZEBMolecular dockingActive site
2010
BCL6 is critical for the development of a diverse primary B cell repertoire
Duy C, Yu JJ, Nahar R, Swaminathan S, Kweon SM, Polo JM, Valls E, Klemm L, Shojaee S, Cerchietti L, Schuh W, Jäck HM, Hurtz C, Ramezani-Rad P, Herzog S, Jumaa H, Koeffler HP, de Alborán IM, Melnick AM, Ye BH, Müschen M. BCL6 is critical for the development of a diverse primary B cell repertoire. Journal Of Experimental Medicine 2010, 207: 1209-1221. PMID: 20498019, PMCID: PMC2882829, DOI: 10.1084/jem.20091299.Peer-Reviewed Original ResearchMeSH KeywordsADP-Ribosylation FactorsAnimalsApoptosisB-LymphocytesBase SequenceCell ProliferationCell SurvivalCells, CulturedCytoprotectionDNA DamageDNA-Binding ProteinsDown-RegulationGene Rearrangement, B-Lymphocyte, Light ChainHumansInterleukin-7LymphopoiesisMiceMolecular Sequence DataPre-B Cell ReceptorsPrecursor Cells, B-LymphoidProto-Oncogene Proteins c-bcl-6Proto-Oncogene Proteins c-mycRecombination, GeneticSignal TransductionTranscription, GeneticUp-RegulationConceptsDNA damage-induced apoptosisDamage-induced apoptosisImmunoglobulin light chain gene recombinationPre-B cell receptorBone marrow immature B cellsB cell developmentClass switch recombinationAbsence of Bcl6B cell repertoireExpression of BCL6Immature B cellsMu heavy chainDNA breaksNegative regulationPrimary B-cell repertoireGene recombinationCell developmentClonal diversityB cellsGerminal center B cellsSomatic hypermutationB cell precursorsExpression levelsBCL6 expressionCell precursors