2010
Promoting Social Skill Development in Children With Pervasive Developmental Disorders: A Feasibility and Efficacy Study
Koenig K, White SW, Pachler M, Lau M, Lewis M, Klin A, Scahill L. Promoting Social Skill Development in Children With Pervasive Developmental Disorders: A Feasibility and Efficacy Study. Journal Of Autism And Developmental Disorders 2010, 40: 1209-1218. PMID: 20204689, DOI: 10.1007/s10803-010-0979-x.Peer-Reviewed Original ResearchConceptsOutcome measuresPervasive developmental disorderSecondary outcome measuresPrimary outcome measureDevelopmental disordersEfficacy studiesSkills interventionSocial skills interventionsGroup interventionGroup comparisonsParent questionnaireInterventionAge 8ChildrenPreliminary evidenceTreatmentDisordersSocial skills developmentAppropriate social behaviorHigh levelsHighlight challenges
2002
Risperidone in Children with Autism and Serious Behavioral Problems
McCracken JT, McGough J, Shah B, Cronin P, Hong D, Aman MG, Arnold LE, Lindsay R, Nash P, Hollway J, McDougle CJ, Posey D, Swiezy N, Kohn A, Scahill L, Martin A, Koenig K, Volkmar F, Carroll D, Lancor A, Tierney E, Ghuman J, Gonzalez NM, Grados M, Vitiello B, Ritz L, Davies M, Robinson J, McMahon D. Risperidone in Children with Autism and Serious Behavioral Problems. New England Journal Of Medicine 2002, 347: 314-321. PMID: 12151468, DOI: 10.1056/nejmoa013171.Peer-Reviewed Original ResearchConceptsClinical Global Impression-ImprovementAtypical antipsychotic agentsPlacebo groupSelf-injurious behaviorRisperidone groupAntipsychotic agentsAutistic disorderIrritability scoresDouble-blind trialPrimary outcome measureTreatment of adultsTraditional antipsychotic medicationsPercent decreaseSerious behavioral disturbancesAberrant Behavior ChecklistRisperidone therapyTardive dyskinesiaAntipsychotic medicationAverage weight gainOutcome measuresPositive responsePostsynaptic dopamineSerotonin receptorsBehavioral disturbancesSevere tantrums