The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers
Anderson-Hanley C, Stark J, Wall KM, VanBrakle M, Michel M, Maloney M, Barcelos N, Striegnitz K, Cohen BD, Kramer AF. The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers. Clinical Interventions In Aging 2018, 13: 1565-1577. PMID: 30233154, PMCID: PMC6130272, DOI: 10.2147/cia.s160756.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentOlder adultsCognitive impairmentVerbal memoryExecutive functionNeurobiological outcomesNeuropsychological functionNeurobiological mechanismsCognitive functionMental exerciseHealthy agingPilot clinical trialBiomarker measuresClinical trialsPilot dataAdultsSalivary biomarkersImpairmentCognitionFurther researchMemoryPosttrialInadequate dosePreliminary indicationParticipants