2000
Regulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase Pathway*
Martin K, Schalm S, Richardson C, Romanelli A, Keon K, Blenis J. Regulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase Pathway*. Journal Of Biological Chemistry 2000, 276: 7884-7891. PMID: 11108711, DOI: 10.1074/jbc.m006969200.Peer-Reviewed Original ResearchMeSH KeywordsCdc42 GTP-Binding ProteinCells, CulturedHumansIsoenzymesPhosphatidylinositol 3-KinasesProtein Kinase CRibosomal Protein S6 KinasesConceptsProtein kinase CzetaC-terminusPhosphoinositide-dependent kinase 1Ribosomal S6 kinase 2S6 kinase 2PI3K effectorsRibosomal S6 kinaseRibosomal protein S6Agonist-dependent activationS6 kinaseProtein S6Kinase activityKinase 2Kinase 1Translational capacityS6K2Terminal sequencePhysiological roleImportant regulatorRapamycin (mTOR) pathwayMammalian targetS6K1Basal activationTerminusHomologRibosomal S6 Kinase 2 Inhibition by a Potent C-terminal Repressor Domain Is Relieved by Mitogen-activated Protein-Extracellular Signal-regulated Kinase Kinase-regulated Phosphorylation*
Martin K, Schalm S, Romanelli A, Keon K, Blenis J. Ribosomal S6 Kinase 2 Inhibition by a Potent C-terminal Repressor Domain Is Relieved by Mitogen-activated Protein-Extracellular Signal-regulated Kinase Kinase-regulated Phosphorylation*. Journal Of Biological Chemistry 2000, 276: 7892-7898. PMID: 11108720, DOI: 10.1074/jbc.m009972200.Peer-Reviewed Original ResearchMeSH KeywordsButadienesCells, CulturedEnzyme ActivationEpidermal Growth FactorHumansIsoenzymesMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein Kinase KinasesMitogen-Activated Protein KinasesNitrilesPhosphatidylinositol 3-KinasesPhosphorylationRibosomal Protein S6 KinasesConceptsNuclear localization signalLocalization signalPhosphorylation sitesProtein kinaseMitogen-activated protein kinase phosphorylation siteC-terminal nuclear localization signalSerine/threonine protein kinaseProtein kinase phosphorylation siteSignal-regulated kinase kinaseRibosomal S6 kinase 2C-terminal phosphorylation sitesC-terminal repressor domainThreonine protein kinaseKinase phosphorylation siteC-terminal motifMitogen-activated protein kinasePhosphorylation site mutationsS6 kinase 2C-terminal domainKinase kinase inhibitor U0126Ribosomal protein S6C-terminal deletionsC-terminal regionKinase inhibitor U0126Site-specific mutations
1999
p70 S6 Kinase Is Regulated by Protein Kinase Cζ and Participates in a Phosphoinositide 3-Kinase-Regulated Signalling Complex
Romanelli A, Martin K, Toker A, Blenis J. p70 S6 Kinase Is Regulated by Protein Kinase Cζ and Participates in a Phosphoinositide 3-Kinase-Regulated Signalling Complex. Molecular And Cellular Biology 1999, 19: 2921-2928. PMID: 10082559, PMCID: PMC84086, DOI: 10.1128/mcb.19.4.2921.Peer-Reviewed Original ResearchConceptsP70 S6 kinasePDK-1Protein kinase CS6 kinaseGrowth factor-independent mannerK activationPhosphoinositide-dependent kinase 1Atypical protein kinase CC-terminal truncation mutantsPDK-1 activationProtein kinase CζFactor-independent mannerThreonine 389Pseudosubstrate domainSignaling ComplexGrowth factorSequential phosphorylationTruncation mutantsCoexpression experimentsEpidermal growth factorCatalytic loopUpstream regulatorKinase 1PKC isoformsKinase C