2016
Methionine‐Restricted Diet Increases miRNAs That Can Target RUNX2 Expression and Alters Bone Structure in Young Mice
Plummer J, Park M, Perodin F, Horowitz MC, Hens JR. Methionine‐Restricted Diet Increases miRNAs That Can Target RUNX2 Expression and Alters Bone Structure in Young Mice. Journal Of Cellular Biochemistry 2016, 118: 31-42. PMID: 27191548, PMCID: PMC5426510, DOI: 10.1002/jcb.25604.Peer-Reviewed Original ResearchConceptsDietary methionine restrictionBone tissue densityMR miceMethionine restrictionBone marrowMale C57BL/6J miceBone-related biomarkersYoung male C57BL/6J miceBone structureMiR-335-5pPlasma levelsC57BL/6J micePlasma glucoseRodent modelsBone volumeFat depotsTrabecular thicknessFat accretionBone remodelingMiceBiomechanical testingMiR-204Reduced expressionMiR-31Significant decrease
2012
Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme
Hiremath M, Dann P, Fischer J, Butterworth D, Boras-Granic K, Hens J, Van Houten J, Shi W, Wysolmerski J. Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme. Development 2012, 139: 4239-4249. PMID: 23034629, PMCID: PMC3478689, DOI: 10.1242/dev.080671.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta CateninCell DifferentiationFemaleGene Expression Regulation, DevelopmentalKeratinocytesLymphoid Enhancer-Binding Factor 1Mammary Glands, AnimalMesodermMiceMice, KnockoutParathyroid Hormone-Related ProteinReceptors, Parathyroid HormoneThrombospondinsWnt ProteinsWnt Signaling PathwayConceptsLoss of PTHrPOverexpression of PTHrPHormone-related proteinMammary mesenchymeΒ-cateninEmbryonic mammary mesenchymeWnt pathwayWnt/β-cateninEmbryonic mammary developmentCanonical Wnt pathwayPTHrPMammary developmentMammary budAbnormal differentiationReduced expressionBasal keratinocytesVentral skinReporter activityBud cellsMarkersCanonical WntInappropriate differentiationAbolished expressionMesenchyme markersOverexpression