2021
Alcohol and nicotine polygenic scores are associated with the development of alcohol and nicotine use problems from adolescence to young adulthood
Deak JD, Clark DA, Liu M, Schaefer JD, Jang SK, Durbin CE, Iacono WG, McGue M, Vrieze S, Hicks BM. Alcohol and nicotine polygenic scores are associated with the development of alcohol and nicotine use problems from adolescence to young adulthood. Addiction 2021, 117: 1117-1127. PMID: 34590376, PMCID: PMC8931861, DOI: 10.1111/add.15697.Peer-Reviewed Original ResearchAssociations between polygenic risk of substance use and use disorder and alcohol, cannabis, and nicotine use in adolescence and young adulthood in a longitudinal twin study
Schaefer J, Jang S, Clark D, Deak J, Hicks B, Iacono W, Liu M, McGue M, Vrieze S, Wilson S. Associations between polygenic risk of substance use and use disorder and alcohol, cannabis, and nicotine use in adolescence and young adulthood in a longitudinal twin study. Psychological Medicine 2021, 53: 2296-2306. PMID: 37310313, PMCID: PMC10123833, DOI: 10.1017/s0033291721004116.Peer-Reviewed Original ResearchPolygenic scores for smoking and educational attainment have independent influences on academic success and adjustment in adolescence and educational attainment in adulthood
Hicks B, Clark D, Deak J, Schaefer J, Liu M, Jang S, Durbin C, Johnson W, Wilson S, Iacono W, McGue M, Vrieze S. Polygenic scores for smoking and educational attainment have independent influences on academic success and adjustment in adolescence and educational attainment in adulthood. PLOS ONE 2021, 16: e0255348. PMID: 34403414, PMCID: PMC8370636, DOI: 10.1371/journal.pone.0255348.Peer-Reviewed Original ResearchConceptsEducational attainment polygenic scoreSmoking PGSAcademic adjustmentPolygenic scoresAcademic variablesSignificant incremental associationsAge 14Minnesota Twin Family StudyGenetic influencesGeneral behavioral disinhibitionNon-cognitive traitsEducation polygenic scoreEducational attainmentTwin Family StudyAcademic motivationBehavioral disinhibitionDifferent genetic influencesDistinct genetic influencesPredictors of gradeIncremental associationAcademic successAdolescenceAge 11Educational successAdulthood
2019
Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior.
Deak J, Gizer I, Otto J, Bizon C, Wilhelmsen K. Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior. Journal Of Studies On Alcohol And Drugs 2019, 80: 585-593. PMID: 31790348, PMCID: PMC6900988, DOI: 10.15288/jsad.2019.80.585.Peer-Reviewed Original ResearchConceptsVariant associationsCommon variant associationsRare variant association testsRare variant signalsGene-based analysisRare variant associationsMolecular genetic studiesSingle variant analysisIntergenic regionRare variationAlcohol use disorderTop associationsSequencing dataVariant contributionsGenetic studiesAlcoholism (COGA) sampleGenetic sequencing dataReceptor geneUse disordersVariant signalsGene variationTypes of variationConfer riskStrong associationSignificant association
2018
Meta‐Analysis of Genetic Influences on Initial Alcohol Sensitivity
Edwards A, Deak J, Gizer I, Lai D, Chatzinakos C, Wilhelmsen K, Lindsay J, Heron J, Hickman M, Webb B, Bacanu S, Foroud T, Kendler K, Dick D, Schuckit M. Meta‐Analysis of Genetic Influences on Initial Alcohol Sensitivity. Alcohol Clinical And Experimental Research 2018, 42: 2349-2359. PMID: 30276832, PMCID: PMC6286211, DOI: 10.1111/acer.13896.Peer-Reviewed Original ResearchConceptsCore clock genesClock genesTissue-specific expression dataPopulation-based genome-wide association studiesGenome-wide association studiesGenome-wide significanceGene identification effortsSignificant genetic correlationsMolecular genetic studiesHormone signalingSingle nucleotide polymorphismsIndividual lociGenetic analysisAssociation studiesGenetic studiesExpression dataGenesGenetic componentGenetic correlationsNucleotide polymorphismsHeritabilityAlcohol sensitivityGenetic factorsLow initial sensitivityGenetic influences
2014
Probing the Smoking–Suicide Association: Do Smoking Policy Interventions Affect Suicide Risk?
Grucza R, Plunk A, Krauss M, Cavazos-Rehg P, Deak J, Gebhardt K, Chaloupka F, Bierut L. Probing the Smoking–Suicide Association: Do Smoking Policy Interventions Affect Suicide Risk? Nicotine & Tobacco Research 2014, 16: 1487-1494. PMID: 25031313, PMCID: PMC4271090, DOI: 10.1093/ntr/ntu106.Peer-Reviewed Original ResearchConceptsSmoking prevalenceCigarette excise taxesSuicide riskSmoke-free air policiesProtective associationSmoking behaviorU.S. Multiple CauseSmoke-free airProbability of smokingSmoking interventionsDeath filesElevated riskPopulation interventionsSmokingSuicide deathsPrevalenceMultiple causesAir policiesRiskInterventionAssociationExcise taxesSuicideDemographic variablesIndividual-level data