2023
Genome-wide analyses reveal shared genetic architecture and novel risk loci between opioid use disorder and general cognitive ability
Holen B, Kutrolli G, Shadrin A, Icick R, Hindley G, Rødevand L, O'Connell K, Frei O, Parker N, Tesfaye M, Deak J, Jahołkowski P, Dale A, Djurovic S, Andreassen O, Smeland O. Genome-wide analyses reveal shared genetic architecture and novel risk loci between opioid use disorder and general cognitive ability. Drug And Alcohol Dependence 2023, 256: 111058. PMID: 38244365, DOI: 10.1016/j.drugalcdep.2023.111058.Peer-Reviewed Original ResearchGenetic basisBivariate causal mixture modelRisk lociGenome-wide analysisNovel risk lociNegative genetic correlationSpecific genetic lociUnderlying molecular mechanismsGenetic risk architectureSpecific genetic variantsGenetic architectureGenetic lociBiological functionsMolecular mechanismsGenetic relationshipsLociGenetic correlationsGenetic variantsGenetic overlapRisk architectureConjunctional FDRNew insightsRecent studiesBiological substratesGenesT18. GENETIC CONTRIBUTION TO THE COMORBIDITY BETWEEN ATTENTION-DEFICIT HYPERACTIVITY DISORDER AND SUBSTANCE USE DISORDERS
Koller D, Mitjans M, Kouakou M, Friligkou E, Mendoza B, Deak J, Pathak G, Kranzler H, Agrawal A, Corominas R, Demontis D, Gelernter J, Ribases M, Cormand B, Polimanti R. T18. GENETIC CONTRIBUTION TO THE COMORBIDITY BETWEEN ATTENTION-DEFICIT HYPERACTIVITY DISORDER AND SUBSTANCE USE DISORDERS. European Neuropsychopharmacology 2023, 75: s171. DOI: 10.1016/j.euroneuro.2023.08.306.Peer-Reviewed Original ResearchGenome-wide association statisticsPleiotropy analysisLinkage disequilibrium score regressionPairwise genetic correlationsGenetic correlation analysisDisequilibrium score regressionProblematic tobacco usePsychiatric Genomics ConsortiumGenetic architectureGenomic SEMGenetic mechanismsGenomics ConsortiumPathogenic lociPleiotropic variantsGenetic relationshipsMillion Veteran ProgramGenetic correlationsScore regressionGenetic contributionAssociation statisticsMolecular targetsBidirectional Mendelian randomization analysisEnvironmental factorsGenetic factorsDrug development
2021
Genetics of substance use disorders: a review
Deak J, Johnson E. Genetics of substance use disorders: a review. Psychological Medicine 2021, 51: 2189-2200. PMID: 33879270, PMCID: PMC8477224, DOI: 10.1017/s0033291721000969.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide variationAlcohol-related traitsLarger GWAS samplesCHRNB4 gene clusterGenetic architectureGene clusterGenetic effortsGWAS findingsGWA findingsRelated traitsGWAS samplesAssociation studiesGenetic relationshipsDownstream analysisGeneticsTraitsGenetic epidemiologyCHRNA5-CHRNA3Genetic etiologyGenetic factorsGenetic influencesPresent reviewRecent advancesGenes