2024
Therapie der Sarkoidose. Ein Positionspapier der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin (DGP)
Skowasch D, Bonella F, Buschulte K, Kneidinger N, Korsten P, Kreuter M, Müller-Quernheim J, Pfeifer M, Prasse A, Quadder B, Sander O, Schupp J, Sitter H, Stachetzki B, Grohé C. Therapie der Sarkoidose. Ein Positionspapier der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin (DGP). Pneumologie 2024, 78: 151-166. PMID: 38408486, DOI: 10.1055/a-2259-1046.Peer-Reviewed Original Research
2021
Abnormal FeV1 and body mass index are associated with impaired cough-related quality of life in sarcoidosis patients
Frye B, Potasso L, Farin E, Fichtner U, Birring S, Müller-Quernheim J, Schupp J. Abnormal FeV1 and body mass index are associated with impaired cough-related quality of life in sarcoidosis patients. Respiratory Medicine 2021, 188: 106600. PMID: 34530353, DOI: 10.1016/j.rmed.2021.106600.Peer-Reviewed Original ResearchConceptsLeicester Cough QuestionnaireCough-related qualityQuality of lifeSarcoidosis patientsLCQ scoreBody mass indexAbnormal FEV1Routine followLung functionOrgan impairmentTreatable traitsMass indexDisease burdenGranulomatous diseaseFEV1PatientsSarcoidosisBMIScoresQuestionnaireLungCohortFollowDiseaseLifeTranscriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis
Vukmirovic M, Yan X, Gibson KF, Gulati M, Schupp JC, DeIuliis G, Adams TS, Hu B, Mihaljinec A, Woolard TN, Lynn H, Emeagwali N, Herzog EL, Chen ES, Morris A, Leader JK, Zhang Y, Garcia JGN, Maier LA, Collman RG, Drake WP, Becich MJ, Hochheiser H, Wisniewski SR, Benos PV, Moller DR, Prasse A, Koth LL, Kaminski N. Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis. European Respiratory Journal 2021, 58: 2002950. PMID: 34083402, PMCID: PMC9759791, DOI: 10.1183/13993003.02950-2020.Peer-Reviewed Original ResearchMeSH KeywordsBronchoalveolar LavageBronchoalveolar Lavage FluidHumansSarcoidosisSarcoidosis, PulmonaryTranscriptomeConceptsWeighted gene co-expression network analysisGene co-expression network analysisCo-expression network analysisGene expression programsGene expression patternsDistinct transcriptional programsImmune response pathwaysIon Torrent ProtonMicroarray expression datasetsExpression programsTranscriptional programsPhenotypic traitsGene modulesResponse pathwaysRNA sequencingMolecular endotypesExpression patternsGene expressionHilar lymphadenopathyOrgan involvementGenomic researchMechanistic targetExpression datasetsT helper type 1T cell immune responsesBronchoalveolar Lavage Fluid Reflects a TH1-CD21low B-Cell Interaction in CVID-Related Interstitial Lung Disease
Friedmann D, Unger S, Keller B, Rakhmanov M, Goldacker S, Zissel G, Frye B, Schupp J, Prasse A, Warnatz K. Bronchoalveolar Lavage Fluid Reflects a TH1-CD21low B-Cell Interaction in CVID-Related Interstitial Lung Disease. Frontiers In Immunology 2021, 11: 616832. PMID: 33613543, PMCID: PMC7892466, DOI: 10.3389/fimmu.2020.616832.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseCommon variable immunodeficiencyBAL fluidB cellsLung diseaseT cellsImmune dysregulationBronchoalveolar lavageHealthy donorsClass-switched memory B cellsLymphocytic interstitial lung diseaseProgressive interstitial lung diseaseLevels of BAFFLike cell subsetSystemic immune dysregulationRegulatory T cellsVideo-assisted thoracoscopyBronchoalveolar lavage fluidT cell populationsPotential immune mechanismsLevels of APRILMemory B cellsB cell interactionsFlow cytometric profilingPotential treatment target
2019
Translation and psychometric properties of the King’s Sarcoidosis Questionnaire (KSQ) in German language
Farin E, Heyduck K, Frye BC, Birring SS, Müller-Quernheim J, Schupp JC. Translation and psychometric properties of the King’s Sarcoidosis Questionnaire (KSQ) in German language. Health And Quality Of Life Outcomes 2019, 17: 62. PMID: 30975148, PMCID: PMC6460543, DOI: 10.1186/s12955-019-1131-z.Peer-Reviewed Original ResearchConceptsKing's Sarcoidosis QuestionnaireGood psychometric propertiesGerman Clinical Trials RegisterGerman versionResultsOne hundred ninetyClinical Trials RegisterHealth-related qualityPsychometric propertiesGeneral health statusRasch model fitStructural validityInternal consistencyConstruct validityTrials RegisterConsecutive patientsSarcoidosis patientsOutpatient clinicInterventional studyLife QuestionnaireHealth statusSarcoidosisPatientsMeasurement propertiesCronbach's alphaStructured interviews
2018
Psychometric properties of the German version of the Leicester Cough Questionnaire in sarcoidosis
Schupp JC, Fichtner UA, Frye BC, Heyduck-Weides K, Birring SS, Windisch W, Criée CP, Müller-Quernheim J, Farin E. Psychometric properties of the German version of the Leicester Cough Questionnaire in sarcoidosis. PLOS ONE 2018, 13: e0205308. PMID: 30286204, PMCID: PMC6171952, DOI: 10.1371/journal.pone.0205308.Peer-Reviewed Original ResearchConceptsLeicester Cough QuestionnaireHRQL questionnairesSarcoidosis patientsHealth-related qualityPsychometric propertiesRasch model fitGerman versionInternal consistencyInterventional trialsCommon symptomsPulmonary medicineClinical settingSarcoidosisPatientsFloor effectsProfound negative impactModerate correlationConcurrent validitySkewed responseStructured interviewsQuestionnaireComparative questionnaireCoughCohortSymptomsPhenotypes of organ involvement in sarcoidosis
Schupp J, Freitag-Wolf S, Bargagli E, Mihailović-Vučinić V, Rottoli P, Grubanovic A, Müller A, Jochens A, Tittmann L, Schnerch J, Olivieri C, Fischer A, Jovanovic D, Filipovic S, Videnovic-Ivanovic J, Bresser P, Jonkers R, O'Reilly K, Ho L, Gaede K, Zabel P, Dubaniewicz A, Marshall B, Kieszko R, Milanowski J, Günther A, Weihrich A, Petrek M, Kolek V, Keane M, O'Beirne S, Donnelly S, Haraldsdottir S, Jorundsdottir K, Costabel U, Bonella F, Wallaert B, Grah C, Peroš-Golubičić T, Luisetti M, Kadija Z, Pabst S, Grohé C, Strausz J, Vašáková M, Sterclova M, Millar A, Homolka J, Slováková A, Kendrick Y, Crawshaw A, Wuyts W, Spencer L, Pfeifer M, Valeyre D, Poletti V, Wirtz H, Prasse A, Schreiber S, Krawczak M, Müller-Quernheim J. Phenotypes of organ involvement in sarcoidosis. European Respiratory Journal 2018, 51: 1700991. PMID: 29371378, DOI: 10.1183/13993003.00991-2017.Peer-Reviewed Original ResearchConceptsOrgan involvementIntrathoracic lymph node involvementAbdominal organ involvementLymph node involvementEuropean multicentre studySystemic granulomatous diseaseNew clinical phenotypeHitherto unknown etiologyAcute onsetExtrapulmonary involvementNode involvementSkin involvementFemale patientsMulticentre studyDisease involvementUnknown etiologyCaucasian patientsGranulomatous diseaseHomogenous cohortSarcoidosisPatientsClinical phenotypeStudy centersStandardised protocolDisease phenotype
2017
Transcriptome profiles in sarcoidosis and their potential role in disease prediction
Schupp JC, Vukmirovic M, Kaminski N, Prasse A. Transcriptome profiles in sarcoidosis and their potential role in disease prediction. Current Opinion In Pulmonary Medicine 2017, 23: 487-492. PMID: 28590292, PMCID: PMC5637542, DOI: 10.1097/mcp.0000000000000403.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGenome-wide expression studiesWide expression studiesTranscriptome profilesTranscriptomic dataRNA sequencingExpression studiesGene expressionMolecular mechanismsLarge prospective followTh1 immune responseTranscriptomeNonnecrotizing granulomasProspective followSystemic diseaseDisease progressionTreatment outcomesImmune responseSarcoidosisPotential roleControl tissuesProgressive sarcoidosisKey roleDiseaseTranscriptomicsGranulomasSarcoidosis: Drugs under Investigation
Schupp J, Frye B, Zissel G, Müller-Quernheim J. Sarcoidosis: Drugs under Investigation. Seminars In Respiratory And Critical Care Medicine 2017, 38: 532-537. PMID: 28750466, DOI: 10.1055/s-0037-1603768.Commentaries, Editorials and Letters
2016
Neue pathogenetische Konzepte und frühe pharmakologische Studien bei der Sarkoidose
Schupp J, Frye B, Zissel G, Müller-Quernheim J. Neue pathogenetische Konzepte und frühe pharmakologische Studien bei der Sarkoidose. Pneumologie 2016, 70: 231-240. PMID: 26937647, DOI: 10.1055/s-0041-108311.Commentaries, Editorials and LettersConceptsSarcoid patientsGranuloma formationSarcoidosis-associated fatigueClinical pharmacological studiesEtiology of sarcoidosisGenetics of sarcoidosisPulmonary hypertensionMycobacterial antigensAntigen presentationSarcoidosisPositive studiesClinical researchPatientsSubcohortAutoimmunityPositive outcomesNew studiesWide association studyAssociation studiesHypertensionAutoantigensPathomechanismEtiologyNew findingsStudy
2015
Diagnostik und Therapie der Sarkoidose
Frye B, Schupp J, Köhler T, Müller-Quernheim J. Diagnostik und Therapie der Sarkoidose. Der Internist 2015, 56: 1346-1352. PMID: 26563335, DOI: 10.1007/s00108-015-3757-1.ChaptersConceptsIntrathoracic lymph nodesLymph nodesGranulomatous diseaseSteroid-refractory diseaseFurther therapeutic optionsNon-necrotizing granulomasDiagnostik und TherapieLung transplantationSarcoidosis treatmentSteroid therapyCNS involvementStarting doseSymptomatic therapyOrgan impairmentTherapeutic optionsUnd TherapieEndobronchial ultrasoundSpontaneous resolutionBody weightSarcoidosisOrphan diseaseMonoclonal antibodiesDiseaseSymptomatic patternGranulomas