2023
Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1-Positive Endothelial Cells.
Schupp J, Manning E, Chioccioli M, Kamp J, Christian L, Ryu C, Herzog E, Kühnel M, Prasse A, Kaminski N, Jonigk D, Homer R, Neubert L, Ius F, stringJustet A, Hariri L, Seeliger B, Welte T, Knipe R, Gottlieb J. Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1-Positive Endothelial Cells. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 819-822. PMID: 37552025, PMCID: PMC10563189, DOI: 10.1164/rccm.202303-0544le.Peer-Reviewed Original ResearchVascular-Parenchymal Cross-Talk Promotes Lung Fibrosis through BMPR2 Signaling.
Yanagihara T, Tsubouchi K, Zhou Q, Chong M, Otsubo K, Isshiki T, Schupp J, Sato S, Scallan C, Upagupta C, Revill S, Ayoub A, Chong S, Dvorkin-Gheva A, Kaminski N, Tikkanen J, Keshavjee S, Paré G, Guignabert C, Ask K, Kolb M. Vascular-Parenchymal Cross-Talk Promotes Lung Fibrosis through BMPR2 Signaling. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 1498-1514. PMID: 36917778, DOI: 10.1164/rccm.202109-2174oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisVascular smooth muscle cellsAdvanced idiopathic pulmonary fibrosisPulmonary hypertensionFibrotic lungsVascular remodelingEndothelial cellsPulmonary fibrosisLung diseaseLung fibrosisDevelopment of PHConcomitant pulmonary hypertensionProgressive lung scarringPulmonary vascular remodelingFibrotic lung diseaseProgression of fibrosisActivation of VSMCsActive TGF-β1Fatal lung diseaseSmooth muscle cellsWhole-exome sequencingLung scarringEndothelial dysfunctionPoor prognosisFibrogenic effects
2022
A Morphomolecular Approach to Alveolar Capillary Dysplasia
Kamp J, Neubert L, Ackermann M, Stark H, Plucinski E, Shah H, Janciauskiene S, Bergmann A, Schmidt G, Welte T, Haverich A, Werlein C, Braubach P, Laenger F, Schwerk N, Olsson K, Fuge J, Park D, Schupp J, Hoeper M, Kuehnel M, Jonigk D. A Morphomolecular Approach to Alveolar Capillary Dysplasia. American Journal Of Pathology 2022, 192: 1110-1121. PMID: 35649494, DOI: 10.1016/j.ajpath.2022.05.004.Peer-Reviewed Original ResearchConceptsAlveolar capillary dysplasiaHigh prevalencePersistent pulmonary arterial hypertensionPulmonary arterial hypertension groupC motif chemokine receptor 4CXCR4 ligand CXCL12Pulmonary arterial hypertensionEndothelial tyrosine kinase receptorHypoxia-inducible factor-1αChemokine receptor 4Anti-angiogenic agentsIntussusceptive angiogenesisArterial hypertensionHypertension groupTyrosine kinase receptorsFatal outcomeHealthy controlsReceptor 4Ligand CXCL12Vascular remodelingMicrovascular corrosion castsACD groupMicrovascular morphologyFactor-1αExome sequencing