2023
Vascular-Parenchymal Cross-Talk Promotes Lung Fibrosis through BMPR2 Signaling.
Yanagihara T, Tsubouchi K, Zhou Q, Chong M, Otsubo K, Isshiki T, Schupp J, Sato S, Scallan C, Upagupta C, Revill S, Ayoub A, Chong S, Dvorkin-Gheva A, Kaminski N, Tikkanen J, Keshavjee S, Paré G, Guignabert C, Ask K, Kolb M. Vascular-Parenchymal Cross-Talk Promotes Lung Fibrosis through BMPR2 Signaling. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 1498-1514. PMID: 36917778, DOI: 10.1164/rccm.202109-2174oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisVascular smooth muscle cellsAdvanced idiopathic pulmonary fibrosisPulmonary hypertensionFibrotic lungsVascular remodelingEndothelial cellsPulmonary fibrosisLung diseaseLung fibrosisDevelopment of PHConcomitant pulmonary hypertensionProgressive lung scarringPulmonary vascular remodelingFibrotic lung diseaseProgression of fibrosisActivation of VSMCsActive TGF-β1Fatal lung diseaseSmooth muscle cellsWhole-exome sequencingLung scarringEndothelial dysfunctionPoor prognosisFibrogenic effects
2017
Sarcoidosis: Drugs under Investigation
Schupp J, Frye B, Zissel G, Müller-Quernheim J. Sarcoidosis: Drugs under Investigation. Seminars In Respiratory And Critical Care Medicine 2017, 38: 532-537. PMID: 28750466, DOI: 10.1055/s-0037-1603768.Commentaries, Editorials and Letters
2016
Editorial: cardiac volume overload and pulmonary hypertension in long‐term follow‐up of TIPSS patients
Rössle M, Schupp J, Köhler T, Schultheiss M. Editorial: cardiac volume overload and pulmonary hypertension in long‐term follow‐up of TIPSS patients. Alimentary Pharmacology & Therapeutics 2016, 43: 1233-1235. PMID: 27137723, DOI: 10.1111/apt.13599.Peer-Reviewed Original ResearchNeue pathogenetische Konzepte und frühe pharmakologische Studien bei der Sarkoidose
Schupp J, Frye B, Zissel G, Müller-Quernheim J. Neue pathogenetische Konzepte und frühe pharmakologische Studien bei der Sarkoidose. Pneumologie 2016, 70: 231-240. PMID: 26937647, DOI: 10.1055/s-0041-108311.Commentaries, Editorials and LettersConceptsSarcoid patientsGranuloma formationSarcoidosis-associated fatigueClinical pharmacological studiesEtiology of sarcoidosisGenetics of sarcoidosisPulmonary hypertensionMycobacterial antigensAntigen presentationSarcoidosisPositive studiesClinical researchPatientsSubcohortAutoimmunityPositive outcomesNew studiesWide association studyAssociation studiesHypertensionAutoantigensPathomechanismEtiologyNew findingsStudy