2020
Multi-dimensional clinical phenotyping of a national cohort of adult cystic fibrosis patients
Conrad D, Billings J, Teneback C, Koff J, Rosenbluth D, Bailey B, Jain R. Multi-dimensional clinical phenotyping of a national cohort of adult cystic fibrosis patients. Journal Of Cystic Fibrosis 2020, 20: 91-96. PMID: 32948498, DOI: 10.1016/j.jcf.2020.08.010.Peer-Reviewed Original ResearchConceptsCystic fibrosis transmembrane conductance regulatorCF patientsCystic fibrosisClinical phenotypeChronic P. aeruginosa infectionDistal intestinal obstruction syndromeAdult cystic fibrosis patientsPseudomonas aeruginosa colonizationUS CF centersAdult CF patientsIntestinal obstruction syndromeTransmembrane conductance regulatorHigh-risk phenotypeWell-nourished groupCholestatic liver diseaseGroup of patientsCystic fibrosis patientsRates of pancreatic insufficiencyMulti-system disorderPancreatic malabsorptionObstruction syndromeChronic sinusitisConductance regulatorPancreatic insufficiencyCF centers
2014
EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production
Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier LL, Nadel JA, Koff JL. EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2014, 307: l186-l196. PMID: 24838750, PMCID: PMC4101792, DOI: 10.1152/ajplung.00368.2013.Peer-Reviewed Original ResearchConceptsRespiratory viral infectionsRespiratory syncytial virusCXCL10 productionRespiratory virusesViral infectionIFN regulatory factorAirway epitheliumEGFR activationChronic obstructive pulmonary diseaseEpithelial cellsExacerbation of asthmaObstructive pulmonary diseaseRecruitment of lymphocytesAdaptive immune responsesAirway epithelial cellsNADPH oxidase activationInhibition of EGFRVirus-infected cellsHuman viral pathogensPulmonary diseaseSyncytial virusEpithelial productionIL-8Viral pneumoniaEpidermal growth factor receptor (EGFR) activation
2012
Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection
Sayah DM, Koff JL, Leard LE, Hays SR, Golden JA, Singer JP. Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection. Clinical Transplantation 2012, 27: e64-e71. PMID: 23278569, PMCID: PMC3558613, DOI: 10.1111/ctr.12054.Peer-Reviewed Original ResearchConceptsLung transplant recipientsAcute rejectionAllograft functionCARV infectionBiopsy-proven acute rejectionIncidence of ARLung allograft functionTransbronchial biopsy resultsReference groupChronic allograft rejectionRespiratory virus infectionsAllograft dysfunctionLung allograftsTransplant recipientsAllograft rejectionExpiratory volumePrimary outcomeRespiratory virusesAdverse outcomesClinical recordsRV infectionBaseline incidenceBiopsy resultsMonths postinfectionVirus infection
1998
Endoscopic Sclerotherapy in Porcine Esophagus Changes Luminal Cross-Sectional Area and Wall Distensibility Dose- and Time-Dependently
Aage J, Petersen K, Djurhuus C, Koff J, Vinter-Jensen L, Gregersen H. Endoscopic Sclerotherapy in Porcine Esophagus Changes Luminal Cross-Sectional Area and Wall Distensibility Dose- and Time-Dependently. Digestive Diseases And Sciences 1998, 43: 521-528. PMID: 9539646, DOI: 10.1023/a:1018802922374.Peer-Reviewed Original Research