2023
COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation
Patton M, Orihuela C, Harrod K, Bhuiyan M, Dominic P, Kevil C, Fort D, Liu V, Farhat M, Koff J, Lal C, Gaggar A, Richter R, Erdmann N, Might M, Gaggar A. COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation. Critical Care 2023, 27: 34. PMID: 36691080, PMCID: PMC9868503, DOI: 10.1186/s13054-023-04312-0.Peer-Reviewed Original ResearchConceptsBacterial co-infectionNeutrophil-to-lymphocyte ratioIn-hospital mortalityMechanical ventilationICU admissionCo-infectionRisk factorsSARS-CoV-2 variantsCohort studyIncreased riskPrimary outcomeIncreased risk of in-hospital mortalityRisk of in-hospital mortalityCommunity-acquired bacteremiaCulture-positive resultsRetrospective cohort studySingle-center reportsInpatient encountersMultivariate logistic regressionBlood culturesPrognostic indicatorOmicron SARS-CoV-2 variantComparison cohortOdds ratioSevere disease
2020
Multi-dimensional clinical phenotyping of a national cohort of adult cystic fibrosis patients
Conrad D, Billings J, Teneback C, Koff J, Rosenbluth D, Bailey B, Jain R. Multi-dimensional clinical phenotyping of a national cohort of adult cystic fibrosis patients. Journal Of Cystic Fibrosis 2020, 20: 91-96. PMID: 32948498, DOI: 10.1016/j.jcf.2020.08.010.Peer-Reviewed Original ResearchConceptsCystic fibrosis transmembrane conductance regulatorCF patientsCystic fibrosisClinical phenotypeChronic P. aeruginosa infectionDistal intestinal obstruction syndromeAdult cystic fibrosis patientsPseudomonas aeruginosa colonizationUS CF centersAdult CF patientsIntestinal obstruction syndromeTransmembrane conductance regulatorHigh-risk phenotypeWell-nourished groupCholestatic liver diseaseGroup of patientsCystic fibrosis patientsRates of pancreatic insufficiencyMulti-system disorderPancreatic malabsorptionObstruction syndromeChronic sinusitisConductance regulatorPancreatic insufficiencyCF centers