2018
Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium
Kalinowski A, Galen B, Ueki I, Sun Y, Mulenos A, Osafo-Addo A, Clark B, Joerns J, Liu W, Nadel J, Dela Cruz C, Koff J. Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium. Mucosal Immunology 2018, 11: 958-967. PMID: 29411775, PMCID: PMC6431552, DOI: 10.1038/mi.2017.120.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusEpidermal growth factor receptorEGFR inhibitionGrowth factor receptorRSV infectionSyncytial virusViral infectionRegulatory factor 1Lower respiratory tract infectionsIFN-λ productionRespiratory tract infectionsChronic lung diseaseFactor receptorAntiviral immune responseFactor 1RSV F proteinType III IFNsAntiviral defenseEGFR activationInnate antiviral responseInterferon regulatory factor 1Cause pneumoniaRSV inducesSignificant IFNTyrosine kinase receptors
2014
EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production
Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier LL, Nadel JA, Koff JL. EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2014, 307: l186-l196. PMID: 24838750, PMCID: PMC4101792, DOI: 10.1152/ajplung.00368.2013.Peer-Reviewed Original ResearchConceptsRespiratory viral infectionsRespiratory syncytial virusCXCL10 productionRespiratory virusesViral infectionIFN regulatory factorAirway epitheliumEGFR activationChronic obstructive pulmonary diseaseEpithelial cellsExacerbation of asthmaObstructive pulmonary diseaseRecruitment of lymphocytesAdaptive immune responsesAirway epithelial cellsNADPH oxidase activationInhibition of EGFRVirus-infected cellsHuman viral pathogensPulmonary diseaseSyncytial virusEpithelial productionIL-8Viral pneumoniaEpidermal growth factor receptor (EGFR) activation